The Serine Protease Plasmin Cleaves the Aminoterminal Domain

  • Slides: 8
Download presentation
The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR 2 A Subunit

The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR 2 A Subunit to Relieve Zinc Inhibition of the N-Methyl-d-aspartate Receptors* Hongjie Yuan, Katie M. Vance, Candice E. Junge, Matthew T. Geballe, James P. Snyder, John R. Hepler, Manuel Yepes, Chian-Ming Low, Stephen F. Traynelis Journal of Biological Chemistry Volume 284 Issue 19 Pages 12862 -12873 (May 2009) DOI: 10. 1074/jbc. M 805123200 Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 1 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 1 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 2 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 2 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 3 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 3 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 4 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 4 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 5 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 5 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 6 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 6 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 7 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200)

FIGURE 7 Journal of Biological Chemistry 2009 28412862 -12873 DOI: (10. 1074/jbc. M 805123200) Copyright © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIBRINOLYTICS THROMBOLYTICS Plasmin It is the protease enzymeFIBRINOLYTICS THROMBOLYTICS Plasmin It is the protease enzyme
Serine proteases Named because they use a serineSerine proteases Named because they use a serine
Role of Serine Protease Inhibitor SERPINB 3 inRole of Serine Protease Inhibitor SERPINB 3 in
Mutations of the Serine Protease CAP 1Prss 8Mutations of the Serine Protease CAP 1Prss 8
Structural Insight into Serine Protease Rv 3671 cStructural Insight into Serine Protease Rv 3671 c
Unraveling the Allosteric Mechanism of Serine Protease InhibitionUnraveling the Allosteric Mechanism of Serine Protease Inhibition
Reelin Is a Serine Protease of the ExtracellularReelin Is a Serine Protease of the Extracellular