The Road to Kidney Transplant A Patients Perspective
- Slides: 35
The Road to Kidney Transplant: A Patients Perspective May 23, 2011 Rhonda Duggan, BSN, RN, CCTC Kidney Transplant Coordinator
Objectives: · Learner will be able to name treatment modalities for ESRD and associated mortality · Learner will be able to name advantages & disadvantages of kidney transplant. · Learner will be able to list required testing involved in kidney transplant evaluation
Living with CKD and Lifestyle Choices · For people with chronic kidney disease, there are lifestyle choices regarding diet, exercise and smoking that may help prevent kidney disease from advancing to kidney failure. · Chronic kidney disease usually occurs gradually over time, therefore, finding out you have kidney disease in the early stages provides an opportunity to slow the progression of CKD. · However, once a patient has lost nearly 90% of their kidney function, the only treatment options are dialysis or a kidney transplant. While dialysis replaces failed renal function, a transplant replaces a diseased kidney
When do you to decide? · Stage 1 with normal or high GFR · · (GFR > 90 ml/min) Stage 2 Mild CKD (GFR = 60 -89 ml/min) Stage 3 Moderate CKD (GFR = 3059 ml/min) Stage 4 Severe CKD (GFR = 15 -29 ml/min) Stage 5 End Stage CKD (GFR <15 ml/min)
How do you decide which modality is right for you? ·Hemodialysis (Home vs. In Center) ·Peritoneal ·Transplant ·No treatment
Why Kidney Transplant? • It’s expensive • There’s not enough donors • ? Quality of life issues
Advantages of successful transplant • Freedom from dialysis • Increased strength & ability to engage in a more physically active lifestyle • Fewer dietary restrictions • Improved blood counts & improvement of uremia symptoms • Less progression of nerve damage • Improved life satisfaction, physical & emotional well being • Potential to return to work or school without disability
Disadvantages of kidney transplant · Unfortunately, there are no guarantees in transplantation. · Need to take anti-rejection medications as long as transplanted kidney is functioning. These medications have potential for significant adverse effects. · Anti-rejection medications are very expensive. · If disability is dependent upon end stage organ disease, it will be discontinued after a successful transplant. · Frequent & chronic follow-up with Transplant Physician, as often as 2 -3 times a week following discharge from hospital. · Worsening of current medical problems · Organ may not work
Inhibiting Factors to Transplantation · Over 90, 000 people are on · · transplant lists Lack of supportive care for patients Lack of knowledge of the transplant process Religious beliefs Cost of healthcare continues to rise and more patients have limited financial resources
Who can be evaluated for kidney transplant?
Contraindications to Kidney Transplantation · · · · · Active malignancy Cirrhosis (Unless simultaneous liver transplant is planned) Severe myocardial dysfunction Active mental illness/Dementia Severe Pulmonary Hypertension Active substance abuse Extreme obesity Non-adherence No support/ financial or social
Conditions Requiring Treatment Prior to Transplantation · · · Active infection Peptic ulcer disease /Diverticulitis Malignancy Cardiovascular disease Cerebrovascular disease/Peripheral vascular disease Substance abuse
The Road to Transplant Begins
How the Kidney Transplant Evaluation Begins · Referral from Nephrologist · Dialysis units are regulated/mandated by CMS to address transplant as a treatment option for every patient · Initial Insurance Approval for evaluation · CMC has contracts with most major insurance companies · Referral reviewed by Intake Nurse/Patient contacted · Patient scheduled for Group Teaching Session · If a high risk candidate, appt scheduled with nephrologist 6
The Transplant Team Once a patient attends the Group Teaching Session, They are assigned a team which consist of each of the following: Transplant Coordinator Medical Social Worker Financial Coordinator Transplant Nephrologist Transplant Surgeon Dietician And now the evaluation can begin ……
Evaluation Appointments · RN – Transplant Coordinator · Social Worker · Financial Coordinator · Dietician if needed · Nephrologist · Surgeon · Consults as indicated
Evaluation Tests · · · Labs EKG Chest X-Ray Other tests as indicated Patient responsible to complete · · · Yearly Dental Yearly Pap (Females) Yearly Mammogram (Females) Colonoscopy (> age 50) Yearly TB skin test (PPD)
APPROVAL/LISTING · Present to Selection Committee · Final Insurance Approval · UNOS Wait Listing · Phone notification · Letter to you and your Dialysis Unit or Nephrologist · Monthly red top tube of blood to Immunology Lab · Proceed with Living Donor Evaluation And now the waiting begins……
Types of Transplant Deceased Donor o Standard Criteria Donor (SCD) o Expanded Criteria Donor (ECD) o Donation after Cardiac Death (DCD) Living Donor o o Living Related (LRD) Living Unrelated (LUR) Good Samaritan/Altruistic Donor Paired Exchange
How successful are transplants and does donor type really make a difference? Deceased Donor Graft Survival @ 1 year 90. 4% Deceased Donor Patient Survival @ 1 yr. 95% Living Donor Graft Survival @ 1 year 95. 6% Living Donor Patient Survival @ 1 yr 98. 2 http: //optn. transplant. hrsa. gov/ar 2008/113_surv-new_dh. htm
One Year Unadjusted Graft Survival by Year, Living and Deceased Donor Kidney Transplants Center Activity (07/01/200806/30/2009) Center Regio United Stat n es Deceased donor transplants (n=number) 86 1, 165 Living donor transplants (n) 33 436 On waitlist at start (n) 377 6, 530 On waitlist at end (n) 649 7, 092 Number of new patient registrations (n) 422 3, 066 Tables for More Information 10, 58 07 C, 08 C, 0 9 C 9 07 L, 08 L, 09 L 6, 232 78, 41 01, 02, 03 7 83, 05 01, 02 3 32, 98 7 01, 02
WHERE AM I ON THE LIST? I’m ready to go!
United Network of Organ Sharing (UNOS) · Non-profit and charitable organization · National transplant data base · Monitors transplant centers compliance · Maintains transplant policies · Multiple listing · Wait time transfer · Organ distribution
UNOS Waiting List Point System · For every donor there is a specific list of candidates based on points. · Each recipient receives points based on the following: · · Matching (Antigens) Waiting Time Antibody Level (PRA) Age less than 18
How are Kidneys Matched? · · · Blood type HLA (tissue typing) Time Waiting Medical Urgency Antibody Level Geographic areas/Availability
Blood Groups Percentage of blood groups in the population O = 46 % A = 39% B = 11% AB = 4% Average waiting times on the list vary according to blood type.
The Waiting List at Carolinas Medical Center (as of 5/16/11) A Active: 126 Inactive: 103 B 87 54 AB 12 13 O Total Patients 224 Active: 449 141 Inactive: 311 Total Patients Listed: 760
You wait, and wait! · Update routine health maintenance test · Re-evaluation Annually or as Indicated And then wait a little more…. .
Getting the Call!!! And the What if’s? ? • The crossmatch is positive… Back-up will be called • You are not medically cleared… Back-up will be called • The kidneys are not usable… You will go home
Surgical Work-up · · · · Admission to Room Labs Chest x-ray EKG Evaluation by Nurse & Physicians Dialysis (if needed) Other tests (if needed) If medically cleared, then it’s off to the operating room!!!
Kidney Transplant Surgery
The Wait is Finally Over!! The patient has crossed the bridge from waiting for a kidney to life after a kidney transplant.
Special thanks to Bruce Wrenn for sharing his story and his family’s road to kidney transplant. Stay tuned for Part 2: Life After a Kidney Transplant
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