The Precision Imperative Blending Advanced Technologies to Meet

The Precision Imperative: Blending Advanced Technologies to Meet Individual Needs Giulia Boselli Precision Medicine Knowledge Transfer Manager - KTN GIANT Health Tech 22 November 2018

Agenda - Intro to Innovate UK and KTN The innovation journey Peculiarity of the heath innovation landscape The challenge of population scale precision medicine Digital pathology, radiology centres as examples The way forward

KTN – Innovate UK’s Networking Partner What: KTN connects people to drive innovation How: Combining in-depth sector-specific knowledge with the ability to cross boundaries

Innovate UK Definition of Precision Medicine Enabling early and accurate diagnosis to inform patient management or selection of therapy

Precision Medicine Technologies Source: The Personalised Medicine Technology Report (phg Foundation)

How to Make Precision Medicine Scalable & Mainstream? The UK approach

Industrial Strategy Grand Challenges

Data for Early Diagnosis & Precision Medicine

Genomics Stream • Aims to position the UK at the forefront of large scale WGS for diagnostics and precision medicine • Whole Genome Sequencing of all 500, 000 UK Biobank volunteers • Potential for additional sequencing of up to 25, 000 cancer patients (tumour and germline genome) – funds permitting • Overarching aim to support generation of novel diagnostic tools and precision therapies, in partnership with industry

Digital Innovation Hubs Stream • Delivered by UKRI in partnership with HDR UK and the NHS, building on investments from NHS England the devolved nations • Hubs will provide expert research data services, supporting analytical tool development and a range of innovative user requirements • A single UK-wide health research data fabric will ensure interoperability across all Hubs • ~£ 38 m over 4 years

Creating a Network of Digital Pathology, Radiology and AI Centres • Up to £ 50 million investment to establish a framework and governance structure to enable organisations to work together to deliver: – Data sharing and interoperability – Advanced data storage and analytical environments capable of managing large numbers of digital images and associated data. – The highest standards of data security, privacy and ethical approval, embedding public trust and engagement into the programme from the outset

The Centres • London Medical Imaging and Artificial Intelligence Centre for Value-Based Healthcare • Glasgow’s I-CAIRD (Industrial Centre for AI Research in Digital Diagnostics • NCIMI (National Consortium of Intelligent Medical Imaging) • The Northern Pathology Imaging Collaborative (NPIC) • The Pathology image data Lake for Analytics, Knowledge and Education (Path. LAKE)

A new paradigm Source: Life Sciences 4. 0: Securing value through data-driven platforms (EY)

The Way Forward – From Silos to Whole Source: Life Sciences 4. 0: Securing value through data-driven platforms (EY)

Thank you! If you require any further support or information please contact: Giulia. Boselli@ktn-uk. org - support@innovateuk. gov. uk Or visit www. ktn-uk. org