The Powerheart G 5 Life needs heroes Heroes

The Powerheart G 5 ® Life needs heroes. Heroes need the G 5. May, 2012 1

Agenda • Sudden Cardiac Arrest (SCA) • Defibrillation • The Powerheart G 5 AED 2

1 The Problem: Sudden Cardiac Arrest 3

SCA Deaths by Geography Sudden Cardiac Arrest: The Problem Japan Europe Sudden Cardiac Arrest (SCA) kills more than 400, 000 Europeans each year. North America China India SCA-related Deaths Per Year 4

Sudden Cardiac Arrest • The heart’s electrical impulses suddenly misfire. • Ventricular Fibrillation (VF) initiates most SCA heart rhythms. • In VF, the heart “quivers” uncontrollably and cannot pump blood. • SCA rarely converts spontaneously. It’s ultimately a defibrillator that restarts the heart. Source: AHA website, http: //www. heart. org/HEARTORG/Conditions/Arrhythmia/About. Arrhythmia/Ventricular. Fibrillation_UCM_324063_Article. jsp, accessed February 2012. 5

Sudden Cardiac Arrest • More than 50% of victims have no previous symptoms of coronary heart disease. 1 • Survival rates decrease by 10 -12% per minute. 2 • Each minute without oxygen diminishes the likelihood the victim will return to a “normal life. ” 1. Thom et al. “Heart Disease and Stroke Statistics – 2006 Update. ” Circulation, 2006: 113, e 85 -e 151. 2. Koster et al. “European Resuscitation Council Guidelines for Resuscitation 2010: Section 2, ” 2010, 1223. 6

Waiting for EMS is not enough • 94% of SCA victims die before reaching the hospital. 1 • The average call-to-shock time for a “typical community” is 11 minutes. 2 • Defibrillation within three minutes can increase survival rates to 75%. 3 1. Thom et al. “Heart Disease and Stroke Statistics – 2006 Update. ” Circulation, 2006: 113, e 85 -e 151. 2. Koster et al. “European Resuscitation Council Guidelines for Resuscitation 2010: Section 2”, 2010, 1278. 3. Nolan et al. “European Resuscitation Council Guidelines for Resuscitation 2010: Executive Summary”, 2010, 1223. 7

SCA Chain of Survival 8

Risk Factors • Coronary conditions • Respiratory Arrest • High cholesterol • Electrocution • High blood pressure • Drowning • Smoking • Stress • Obesity • Trauma • Diabetes Sources: Roger et al. “Heart Disease and Stroke Statistics— 2011 Update: A Report from the American Heart Association. ” Circulation, 2011: 123, e 19 -e 103. Nolan et al. “Executive Summary, ” ERC Guidelines for Resuscitation 2010, 1219. 9

Life-Threatening Arrhythmias • A normal heart rhythm has a distinct pattern • Fast or chaotic arrhythmias don’t allow the heart to effectively pump blood - • VF (Ventricular Fibrillation) VT (Pulseless Ventricular Tachycardia) Automated External Defibrillators (AEDs): designed to treat VF and VT Normal Heart Rhythm Ventricular Fibrillation (VF) Ventricular Tachycardia (VT) 10

AED Protocol Source: Nolan et al. “Executive Summary, ” ERC Guidelines for Resuscitation 2010, 1227. 11

2 Defibrillation 12

Defibrillation • Objective: restore an organised heart rhythm and spontaneous circulation • Delivers electrical current across the heart • Successful defibrillation “depolarizes” the heart’s cells • Depolarization allows the cells to “reorganise” • Defibrillation is the ONLY effective cure for VF! 13

3 The Solution: The Powerheart G 5 AED 14

Introducing the Powerheart G 5 AED The first AED that combines: • Rescue Ready® self-testing • Real-time CPR feedback • User-paced prompts • Fast shock times • Customised escalating energy For reliability, ease of use and advanced patient care. 15

Ready when needed Rugged design and rigorous self-testing ensure your AED will perform, even in harsh environments. • Rigorous daily, weekly, and monthly self-tests • High ingress protection rating (IP 55) for dust and water • Tested to military specifications* • Industry-leading warranties *MIL-STD-810 G 16

Easy to Use Real-time CPR feedback helps rescuers deliver CPR in line with Resuscitation Guidelines. • Proper compression rate and depth • Easy-to-follow voice and text prompts 17

Easy to Use So easy to use, even first-time rescuers can perform a successful rescue. • Rescue. Coach™ user-paced voice and text prompts guide users confidently through the rescue • Interchangeable pads simplify placement in a stressful situation 18

Easy to Use So easy to use, even first-time rescuers can perform a successful rescue. • Automatic shock delivery removes user hesitation to expedite patient therapy* • Dual-language options enable almost anyone to respond *Check for local availability. 19

Advanced patient care The Powerheart G 5 is the first AED that can deliver a higher energy shock in less than 10 seconds. * • Fast shock times give a victim the best chance of survival • The G 5 assesses the patient’s therapy needs and delivers customised shock at an appropriate energy level *Typical time-to-shock (post-CPR) 20

Advanced patient care Focus on the patient, not the process. • Adjust the prompts to fit the user’s skill level • Adapt CPR and shock protocols to your requirements and the latest Resuscitation Guidelines • Easily transfer and review rescue data 21

Unparalleled support and expertise • Global leader in defibrillation • More than 400, 000 AEDs deployed worldwide • Robust distribution network • Responsive local support North America Europe Asia Africa South America Australia • Locally-accessible training 22

Our work in Public Access Defibrillation First Response Municipal Transportation Corporate Schools Sport 23

4 Rescue Ready 24

Trusted Worldwide • More than 40 patents delivering unique, industry-leading features • Over 400, 000 Powerheart AEDs deployed worldwide • Available in nearly 100 countries North America Europe Asia Africa South America Australia • 27% US market share 25

Rugged design The Powerheart G 5 meets rigorous standards for performance • High ingress protection rating (IP 55) for water and dust • Tested to military standards 1 - Drop test (1. 22 M) - Shock - Vibration (sine/random) • Tested to IEC standards for electromagnetic interference 2 1. MIL-STD-810 G 2. IEC 60601 -2 -4 26

Rescue Ready technology • All AEDs have three main components - Battery – tested for presence and capacity Defibrillation pads – tested for presence and function Internal circuitry and software • Self-testing ensures the device is Rescue Ready - Daily: test and assess over 62 items Weekly: test and assess over 83 items, adds a partial charge test Monthly: test and assess over 88 items, adds a full energy charge test 27

Rescue Ready technology • If the self-test identifies any issues - Rescue Ready indicator turns red Audible alert every 30 seconds • The mechanical indicator operates without battery power • To identify the problem - Open the lid Refer to the text display or LED indicators 28

5 Ease of Use 29

Real-time CPR feedback • CPR rate and depth • Helps rescuers provide CPR consistent with Resuscitation Guidelines • AED automatically detects Device and provides every 7. 5 seconds (when needed) CPR feedback • Designed to improve CPR compliance for professional and non-professional rescuers 30

Automatic shock delivery • Patented feature eliminates the need to push a button • Expedite the rescue: just open lid, place pads • Eliminates rescuer hesitation to deliver defibrillation therapy 31

AEDs: Are they safe? • Electrical current “leakage” (between the patient and rescuer): no reported cases of harm to rescuers • Recent study: leakage is well within safety standards (<2, 500 microamperes)¹ 1. Michael Lloyd, et al, “Hands-On Defibrillation: An Analysis of Current Flow Through Rescuers In Contact With Patients During Biphasic External Defibrillation”, Circulation, 2008: 117(19), 2510 -2514. 32

Rescue. Coach voice prompts Rescue. Coach technology guides users confidently through the rescue process • User-paced voice and text prompts • Real-time CPR performance feedback 33

Non-polarized pads Defibrillation pads are designed with the non-professional rescuer in mind • Intuitive packaging: clear graphical directions and easypull tab • Non-polarized pads: interchangeable for rapid placement when critical seconds count • Minimum shelf life: 2 -years 34

Pediatric pads • Smaller size for easy placement on smaller victims • AED automatically detects pediatric pads and delivers reduced energy shock • AED Manager: easily customise pediatric protocols 35

Dual language • Convenient for bi-lingual environments • Swap languages with the touch of a button 36

6 Advanced patient care 37

Advanced patient care Provide the best patient care • Fast shock times • Variable escalating energy • Customised rescue protocols • Efficient rescue data transfer and review The first AED that delivers a higher energy shock post. CPR in less than 10 seconds (typically) to give a SCA victim the best chance of survival. 38

Variable escalating energy Only Powerheart AEDs provide a customised approach to energy delivery • Analyses each patient’s impedance to customise the energy level delivered • If more than one shock is necessary, the AED escalates the energy to an appropriate, higher level • Energy range: 95 joules to 354 joules (adult victim) Combining a higher energy shock (post CPR) and fast shock times to give a SCA victim the best chance of survival. 39

Customised shock delivery Advanced AED technology with the proprietary STAR® biphasic waveform • Customises defibrillation energy to deliver the most effective therapy • Treats cardiac arrest patients individually, based on three important characteristics: - Impedance Defibrillation threshold Cellular response 40

Impedance • Defined: the opposition to the flow of electrical current • Patient impedance - The primary barrier to effectively delivering defibrillation energy Each patient’s impedance is unique – due to body tissues (skin, fat, muscle, lungs), pad-to-skin contact and other factors • Higher patient impedance more resistance to defibrillation energy 41

Defibrillation threshold (DFT) • Defined: the minimum current required to defibrillate the heart • Each patient’s DFT is unique • Key factors - Patient anatomy Disease condition Metabolic state of the heart • Must exceed DFT to successfully defibrillate the heart 42

Cellular response • Within the heart, individual cardiac cells respond to the defibrillation shock • After defibrillation, the heart can retain excess charge from the shock • This can lead to immediate re-fibrillation (the heart returns to VF) 43

The Cellular Response Curve • Individual cardiac cells respond to the defibrillation shock • The heart’s cellular response is influenced by - Patient’s impedance Shape of the defibrillation waveform • This principle is characterized by “The Cellular Response Curve” 44

RHYTHMx® technology The RHYTHMx analysis algorithm separates the Powerheart G 5 from the competition • Only deliver a shock when needed • Non-committed shock: cancel a shock if the rhythm changes – even after the shock decision is made 45

Synchronised Shock Unique feature for treatment of VT and SVT arrhythmias • Synchronises on the R-wave • Treats other life-threatening arrhythmias - VT (ventricular tachycardia) - SVT (supra-ventricular tachycardia) • Avoids the vulnerable phase of the cardiac cycle (which may induce VF) 46

Minimum Asystole Threshold (MAT) • The ability of the AED to deliver a shock to fine VF - AHA recommendation is. 150 m. V Powerheart AEDs detect at. 08 m. V Competitive AEDs vary • Below this factor, arrhythmias are treated as asystole – and no shock is delivered • For AEDs with high MAT: fine VF may be diagnosed as asystole; no shock delivered 47

Flexible rescue settings • Customise your settings to match user skills and preferences - Independent settings for adult and pediatric - Voice prompts: basic, standard, advanced detail - CPR settings: Compression-Only, 30: 2, CPR First and more - Shock protocols: 10 energy settings; shock stacking • Easily update settings if Guidelines change in the future • AED Manager provides easy access 48

AED Manager – Configurations 49

AED Manager – Rescue Data 50

Data Recording • 90 minutes of AED & rescue data - AED Information ECG CPR Rescue prompt information • AED data: history logs and self-test information • Multiple rescue functionality 51

Data transfer • Easy communications - Transfer AED & rescue data Load software upgrades (if available) Customise rescue settings • Use your USB drive or cable - USB drive: automatic data transfer USB cable: one-button data transfer • USB data port located under the pad connector 52

Powerheart G 5 Accessories • Adult pads with CPR Device • Adult and Pediatric Pads • Carry Case or Carry Sleeve • Ready Kit • Rescue Backpack • Storage Solutions • AED Trainer 53

Powerheart AED G 5 54

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