The NOTCH pathway is recurrently mutated in diffuse

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The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis

The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection by Luca Arcaini, Davide Rossi, Marco Lucioni, Marta Nicola, Alessio Bruscaggin, Valeria Fiaccadori, Roberta Riboni, Antonio Ramponi, Virginia V. Ferretti, Stefania Cresta, Gloria Margiotta Casaluci, Maurizio Bonfichi, Manuel Gotti, Michele Merli, Aldo Maffi, Mariarosa Arra, Marzia Varettoni, Sara Rattotti, Lucia Morello, Maria Luisa Guerrera, Roberta Sciarra, Gianluca Gaidano, Mario Cazzola, and Marco Paulli haematol Volume 100(2): 246 -252 January 31, 2015 © 2015 by Ferrata Storti Foundation

Clinical features at presentation of 46 cases of diffuse large B-cell lymphoma associated with

Clinical features at presentation of 46 cases of diffuse large B-cell lymphoma associated with hepatitis C virus infection. Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation

Histological picture of a case of diffuse large B-cell lymphoma exhibiting a perifollicular growth

Histological picture of a case of diffuse large B-cell lymphoma exhibiting a perifollicular growth pattern (A) (HE 20 X) and consisting of cells with abundant clear cytoplasm (B) (Giemsa 40 x), resembling monocytoid B cells, that is reminiscent of a marginal. . . Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation

(A) Mutations of NOTCH genes in diffuse large B-cell lymphoma associated with hepatitis C

(A) Mutations of NOTCH genes in diffuse large B-cell lymphoma associated with hepatitis C virus infection (white: wild-type; red: mutations). Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation

Clinical features of 46 cases of diffuse large B-cell lymphoma associated with hepatitis C

Clinical features of 46 cases of diffuse large B-cell lymphoma associated with hepatitis C virus infection according to NOTCH mutational status. Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation

Comparison of NOTCH 1 and NOTCH 2 mutation diffuse large B-cell lymphoma with or

Comparison of NOTCH 1 and NOTCH 2 mutation diffuse large B-cell lymphoma with or without hepatitis C virus infection. Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation

Prognostic factors at univariate analyses in 46 patients with diffuse large B-cell lymphoma associated

Prognostic factors at univariate analyses in 46 patients with diffuse large B-cell lymphoma associated with hepatitis C virus infection. Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation

Overall survival of 46 patients with diffuse large B-cell lymphoma associated with hepatitis C

Overall survival of 46 patients with diffuse large B-cell lymphoma associated with hepatitis C virus infection according to mutational status of NOTCH pathway. Luca Arcaini et al. Haematologica 2015; 100: 246 -252 © 2015 by Ferrata Storti Foundation