The Microcirculation Figure 16 1 Guyton and Hall

  • Slides: 15
Download presentation
The Microcirculation Figure 16 -1; Guyton and Hall Copyright © 2006 by Elsevier, Inc.

The Microcirculation Figure 16 -1; Guyton and Hall Copyright © 2006 by Elsevier, Inc.

Structure of Capillary Wall Figure 16 -2; Guyton and Hall Copyright © 2006 by

Structure of Capillary Wall Figure 16 -2; Guyton and Hall Copyright © 2006 by Elsevier, Inc.

Interstitium and Interstitial Fluid Copyright © 2006 by Elsevier, Inc. Figure 16 -4; Guyton

Interstitium and Interstitial Fluid Copyright © 2006 by Elsevier, Inc. Figure 16 -4; Guyton and Hall

Determinants of Net Fluid Movement across Capillaries Figure 16 -5; Guyton and Hall •

Determinants of Net Fluid Movement across Capillaries Figure 16 -5; Guyton and Hall • Capillary hydrostatic pressure (Pc)-tends to force fluid outward through the capillary membrane. • Interstitial fluid pressure (Pif)- opposes filtration when value is positive. Copyright © 2006 by Elsevier, Inc.

Determinants of Net Fluid Movement across Capillaries Figure 16 -5; Guyton and Hall •

Determinants of Net Fluid Movement across Capillaries Figure 16 -5; Guyton and Hall • Plasma colloid osmotic pressure ( c)- opposes filtration causing osmosis of water inward through the membrane • Interstitial fluid colloid pressure ( if) promotes filtration by causing osmosis of fluid outward through the membrane NP = Pc - Pif + if Copyright © 2006 by Elsevier, Inc.

Plasma Proteins and Colloid Osmotic Pressure • 75% of the total colloid osmotic pressure

Plasma Proteins and Colloid Osmotic Pressure • 75% of the total colloid osmotic pressure of plasma results from the presence of albumin and 25% is due to globulins. Albumin Globulins Fibrinogen Total Copyright © 2006 by Elsevier, Inc. gm/dl 4. 5 2. 5 0. 3 7. 3 p(mm. Hg) 21. 8 6. 0 0. 2 28. 0

Determinants of Net Fluid Movement Across Capillaries Figure 16 -5; Guyton and Hall •

Determinants of Net Fluid Movement Across Capillaries Figure 16 -5; Guyton and Hall • Filtration rate = net filtration pressure (NFP) multiplied by the filtration coefficient • Filtration coefficient (Kf) is a product of surface area times the hydraulic conductivity of membrane Copyright © 2006 by Elsevier, Inc.

Forces Causing Filtration at the Arteriole End of the Capillary mm. Hg Forces tending

Forces Causing Filtration at the Arteriole End of the Capillary mm. Hg Forces tending to move fluid outward: Capillary pressure 30 Negative interstitial free fluid pressure 3 Interstitial fluid colloid osmotic pressure 8 TOTAL OUTWARD FORCE 41 Forces tending to move fluid inward: Plasma colloid osmotic pressure 28 TOTAL INWARD FORCE 28 Summation of forces: Outward 41 Inward 28 NET OUTWARD FORCE Copyright © 2006 by Elsevier, Inc. 13

Forces Causing Reabsorption at the Venous End of the Capillary mm. Hg Forces tending

Forces Causing Reabsorption at the Venous End of the Capillary mm. Hg Forces tending to move fluid inward: Plasma colloid osmotic pressure TOTAL INWARD FORCE Forces tending to move fluid outward: Capillary pressure Negative interstitial free fluid pressure Interstitial fluid colloid osmotic pressure TOTAL OUTWARD FORCE Summation of forces: Outward Inward NET INWARD FORCE Copyright © 2006 by Elsevier, Inc. 28 28 10 3 8 21 21 28 7

Net Starling Forces in Capillaries mm. Hg Mean forces tending to move fluid outward:

Net Starling Forces in Capillaries mm. Hg Mean forces tending to move fluid outward: Mean Capillary pressure Negative interstitial free fluid pressure Interstitial fluid colloid osmotic pressure TOTAL OUTWARD FORCE 17. 3 3. 0 8. 0 28. 3 Mean force tending to move fluid inward: Plasma colloid osmotic pressure TOTAL INWARD FORCE 28. 0 Summation of mean forces: Outward Inward NET OUTWARD FORCE 28. 3 28. 0 0. 3 Copyright © 2006 by Elsevier, Inc.

Net Starling Forces in Capillaries Figure opener; Guyton and Hall • Net filtration pressure

Net Starling Forces in Capillaries Figure opener; Guyton and Hall • Net filtration pressure of. 3 mm. Hg which causes a net filtration rate of 2 ml/min for entire body. Copyright © 2006 by Elsevier, Inc.

Question Utilizing the data below, calculate the rate of net fluid movement across the

Question Utilizing the data below, calculate the rate of net fluid movement across the capillary wall: Pressures (in mm. Hg) Plasma colloid osmotic = 20 Capillary hydrostatic = 20 Venous hydrostatic = 5 Arterial = 80 Interstitial hydrostatic = -5 Interstitial colloid osmotic = 5 Filtration coefficient = 10 ml/min/mm. Hg a. 0 ml/min d. 100 ml/min (Reabsorption) b. 10 ml/min (Filtration) e. 10 ml/min (Reabsorption) c. 100 ml/min (Filtration) Copyright © 2006 by Elsevier, Inc.

Lymphatic System Copyright © 2006 by Elsevier, Inc.

Lymphatic System Copyright © 2006 by Elsevier, Inc.

Determinants of Lymph Flow Figure 16 -11; Guyton and Hall • The degree of

Determinants of Lymph Flow Figure 16 -11; Guyton and Hall • The degree of activity of the lymphatic pump - smooth muscle filaments in lymph vessel cause them to contract - external compression also contributes to lymphatic pumping Copyright © 2006 by Elsevier, Inc.

Determinants of Lymph Flow Interstitial fluid hydrostatic pressure Lymph Flow Figure 16 -9; Guyton

Determinants of Lymph Flow Interstitial fluid hydrostatic pressure Lymph Flow Figure 16 -9; Guyton and Hall Figure 16 -10; Guyton and Hall Copyright © 2006 by Elsevier, Inc.

Physiology of microcirculation Microcirculation The microcirculation is thePhysiology of microcirculation Microcirculation The microcirculation is the
MICROCIRCULATION Structure of the Microcirculation and Capillary SystemMICROCIRCULATION Structure of the Microcirculation and Capillary System
Microcirculation and lymphatic system Microcirculation Most purposeful functionMicrocirculation and lymphatic system Microcirculation Most purposeful function
Male Reproductive System Figure 80 1 Guyton HallMale Reproductive System Figure 80 1 Guyton Hall
WalkAlong Theory Figure 6 7 Guyton Hall CopyrightWalkAlong Theory Figure 6 7 Guyton Hall Copyright
Figure 65 6 Guyton Hall Copyright 2006 byFigure 65 6 Guyton Hall Copyright 2006 by
Le figure piane Figure uguali Figure equicomposte FigureLe figure piane Figure uguali Figure equicomposte Figure
Textbooks Textbook of Medical Physiology Guyton and HallTextbooks Textbook of Medical Physiology Guyton and Hall
Hcre HCRE Tbbi Fizyoloji Guyton and Hall ElsevierHcre HCRE Tbbi Fizyoloji Guyton and Hall Elsevier
Chapter 65 Pages 825 827 Guyton Hall PancreaticChapter 65 Pages 825 827 Guyton Hall Pancreatic
Chapter 65 Pages 825 827 Guyton Hall PancreaticChapter 65 Pages 825 827 Guyton Hall Pancreatic
Erythropoiesis TEXTBOOK OF MEDICAL PHYSIOLOGY GUYTON HALL 11Erythropoiesis TEXTBOOK OF MEDICAL PHYSIOLOGY GUYTON HALL 11
Male Reproductive Physiology GUYTON HALL Chapter 80 DRMale Reproductive Physiology GUYTON HALL Chapter 80 DR
Reproductive Physiology of Pregnancy GUYTON HALL Chapter 83Reproductive Physiology of Pregnancy GUYTON HALL Chapter 83