The International Cancer Research Partnership A Global Collaboration

The International Cancer Research Partnership: A Global Collaboration Enabling Analyses of Sponsor-Funded Cancer Research Panel Session 2549 American Evaluation Association EVALUATION 2015 November 11, 2015

Session Presenters Elizabeth Hsu Session Chair Miranda Kleijn Translational Research: Monitoring Trends in the International Cancer Portfolio Senaida Poole Prevention Research: Utilizing a Global Database to Identify and Act on Trends in Research Funding Kari Wojtanik and Lynne Davies Global Assessment of Funding Trends Across a Diverse Spectrum of Issues in Breast Cancer Research Samantha Finstad Assessment of the International Cancer Research Partnership Lung Cancer Portfolio

ICRP: adding value to cancer research ICRP’s mission is to add value to cancer research efforts internationally by fostering collaboration and strategic co-ordination between cancer research organizations. www. icrpartnership. org ICRP Chair 2015 -2017: Dr. Miranda Kleijn Vice-Chair: Dr. Katie Mc. Kenzie

History & milestones • Cancer “CSO” classification tool developed by NCI & CDMRP 2000 • 8 organizations invited to join 2003 2010 2011 • First generation website launched • Agreement to share full data between Partners • New website launched to Partners, giving access to improved analytical tools • Public launch of new ICRP site 2012 • First international analysis of cancer research (2005 -2008) published • Data from 109 organizations included in the ICRP database 2015 • Planned launch of 2 nd International analysis of cancer research (2005+)

ICRP Coding and Database Participating organizations/agencies share high quality, coded data The ICRP database contains data on more than 76, 000 grants from 109 organizations (> $6 bn p. a. ) and is expanding every month. We use this unique resource to ask: § § § § What are the gaps in cancer research? What are the trends in cancer research funding? What types of projects have been funded (e. g. clinical, research, training)? What research areas are being funded (CSO)? What types of cancer are being funded? What is the funding profile across different countries and organizations? How can we maximize our research efforts? How can we foster strategic collaborations between funding organizations? https: //www. icrpartnership. org/database. cfm

Common Scientific Outline (CSO) (ver 2) 1. Biology 1. 1 Normal functioning 1. 2 Chromosome alterations 1. 3 Oncogenes and tumor suppressor genes 1. 4 Progression and metastasis 1. 5 Resources and infrastructure 2. Etiology 2. 1 Exogenous factors 3. Prevention 3. 1 Behavior interventions 2. 2 Endogenous factors 3. 2 Dietary interventions 2. 3 Interactions 3. 3 Chemoprevention 2. 4 Resources and infrastructure 3. 4 Vaccines 3. 5 Complementary and alternative approaches 3. 6 Resources and infrastructure https: //www. icrpartnership. org/CSO. cfm 4. Early detection, diagnosis and prognosis 4. 1 Development and discovery 5. Treatment 5. 1 Localized Development 5. 2 Localized Clinical 6. Control, survivorship, outcome 6. 1 Care and survivorship 6. 2 Surveillance 5. 3 Systemic Development 6. 3 Behavior 4. 2 Evaluation 5. 4 Systemic Clinical 6. 4 Health services 4. 3 Testing in clinical setting 5. 5 Localized + Systemic 6. 5 Education 4. 4 Resources and infrastructure 5. 6 Complementary and alternative approaches 5. 7 Resources and infrastructure 6. 6 End-oflife care 6. 7 Ethics 6. 9 Resources and infrastructure

Cancer Site Codes 47 cancer site codes 9 ‘roll up’ codes (e. g. , urinary cancers, blood cancers) Coded with a “percent relevance” to the site; may sum to more than 100%

Enables structured searches of 1000 s of awards Comprehensive search functionality Users can search by year, organization, city, country, CSO, cancer type, keyword, project type, PI Name….

ICRP: data at the touch of a button Lung cancer research by CSO code, internationally Oesophageal cancer research in the UK

Understanding the cancer research landscape ICRP publishes regular data reports § 2005 -2008 benchmark analysis of cancer research funding § 2005 -2012 trend analysis of international cancer research (publication due in 2015) ICRP data contributes to topic-specific reports led by ICRP or partner organizations Recent ICRP publications: § Obesity & cancer (2014) § Environmental influences on breast cancer (2014) § Metastatic breast cancer (2014) https: //www. icrpartnership. org/publications. cfm

Enabling Cross-Funder Multinational Analyses All grants submitted to the ICRP database are classified by § CSO “Type of research” § Cancer site “Type of cancer” ICRP partners and staff are also developing new tools and methodologies to mine this dataset in more detail § Cross-cutting analysis using keywords, boolean searches § Extracting award data and adding meta-data through a combination of semiautomated and manual coding § Investigating new tools in partnership with others to add value to the data Case studies presented today: § Translational research: monitoring trends in the international cancer portfolio § Prevention research: Utilizing a global database to identify and act on trends in research funding § Global assessment of funding trends across a diverse spectrum of issues in breast cancer research § Assessment of the International Cancer Research Partnership lung cancer portfolio