The Institutional Development Award IDe A Program W

The Institutional Development Award (IDe. A) Program W. Fred Taylor, PH. D. National Institute of General Medical Science National Institutes of Health May 25, 2012

• Program Overview • Centers of Biomedical Excellence (COBRE) • Phase I, Phase III • IDe. A Clinical and Translational Research (IDe. A CTR) • IDe. A Networks of Biomedical Research Excellence (INBRE) • IDe. A Community-Based Research • Selected Examples • IDe. A Co-funding • IDe. A Net • Selected Examples • National Association of IDe. A Principal Investigators (NAIPI) • Selected Science Advances

Program Overview

Institutional Development Award Program • • • Authorized by Congress, 1993 NIH Revitalization Act Intent to enhance geographical distribution of NIH research funds and increase research capacity Currently 23 states and Puerto Rico are IDe. A eligible Similar to NSF Experimental Program to Stimulate Competitiveness in Research (EPSCo. R, est. 1980) Contact: W. Fred Taylor, Ph. D. taylorwf@mail. nih. gov

Institutional Development Award Program Perceived needs to increase research capacity: • • • Core Laboratories Senior and Junior Faculty development Infrastructure (equipment) Facilities alteration and renovation/development Post-doctoral, student and staff development Faculty recruitment Bioinformatics training for students and faculty “State of the Art” Instrumentation Release time for teaching and clinical faculty Undergraduate, post-doctoral recruitment Training opportunities in grant management

Institutional Development Award Program Overall Approach Faculty development • Faculty recruitment and start-up • Funding and release time for research projects • Mentoring to become successful independent investigators Enhancement of research facilities • Core laboratories • State-of-the-art equipment Research education and training • Graduate students, postdoctoral fellows, research staff • Undergraduate students and faculty

INBRE: 24 statewide networks COBRE: 84 thematic research centers VT MT ME ND NH ID SD RI WY NE NV WV KS KY OK NM HI SC AR LA AK DE MS PR

Centers of Biomedical Excellence (COBRE) Phase I, Phase III

Centers of Biomedical Research Excellence (COBRE) Background • COBRE center grant program launched in fiscal year 2000 • To expand develop biomedical faculty research capability • To enhance research infrastructure including core facilities • To build multidisciplinary research centers with a thematic scientific focus at doctoral institutions or research institutes Center Characteristics • Led by an established investigator, funded by NIH, NSF or other comparable Federal or private sector source • At least 3 research sub-projects, all supervised by junior investigators • A clear plan for mentoring, career development and graduation and replacement of junior investigators • Long-term plans for developing and sustaining the center, investigators, collaborations, and physical infrastructure

Model of COBRE Pilot Projects research cores External Advisory Board bioinformatics administrative Administrative and Research Cores • workshops • training courses Mentored Junior Investigator Subprojects Mentors

COBRE • Currently three sequential 5 year phases • • • Phase I: To develop research infrastructure and provide junior (new) investigators mentoring and project funding so they can successfully compete for independent research support Phase II: To further develop research infrastructure and develop a strong critical mass of investigators (new, early stage and established) with shared scientific interests Phase III: To maintain COBRE research cores and to provide support for research pilot projects and mentoring and training

COBRE Develop advanced research infrastructure and a critical mass of investigators in thematic areas Phase I Research Infrastructure Research Projects (Junior Investigators) Phase II Research Infrastructure Research Projects (Junior and Senior Investigators) Phase III Research Cores that are essential for basic and clinical research Pilot Project Program

Centers of Biomedical Research Excellence (COBRE) Phase III: Transitional Centers Purpose • To conduct basic, clinical and translational research • To support essential cores • To sustain a collaborative, multidisciplinary research environment by supporting mentoring and training components. Center Characteristics • Administrative Core (mentoring and training components and pilot projects) • • Core resources including core supplies, service contracts and core management Equipment upgrades and replacement

Summary of COBRE Scientific Themes Number of Grants Neuroscience Cancer Cardiovascular Disease Immunology Proteomics and Genomics Infectious Disease Oral Health Women or Minority Health and Health Disparity (WMHHD) Environmental Science (ES) Muscle Biology (MB) Biochemistry and Biophysics (BB) Drug Discovery and Design (DD) Lung Biology and Disease (LD) Prenatal Biology (PB) Stem Cell Biology (SCB) Bioengineering and Biomaterial 18 9 11 9 8 5 5 4 2 3 2 2 3 1 MB BB DD LD PB SCB ES WMHHD Oral Health Infectious Disease Proteomics and Genomic Immunology

COBRE Progress In fiscal year 2011: • • • 84 COBRE awards supported 786 research projects involving 1482 investigators COBRE centers published 1449 articles with an additional 603 papers in press COBRE investigators made a total of 1882 scientific presentations

IDe. A Clinical and Translational Research (IDe. A CTR)

IDe. A Program Clinical and Translational Research Initiative (IDe. A CTR) Rationale: • • A relatively small proportion (~10%) of IDe. A-funded centers and networks focus on developing clinical and community-based translational research capacity It is critically important to translate the many biomedical research advances from IDe. A states into better health outcomes by forging partnerships between basic and clinical scientists in IDe. A institutions, supported by programs across NIH

IDe. A-CTR Objectives: • To support the development of infrastructure and human resources required to conduct clinical and translational research in IDe. A states. • To enhance the ability of IDe. A institutions and investigators to develop competitive clinical and translational research programs. • To foster and sustain collaboration and coordination of clinical and translational activities within and across IDe. A institutions /organizations.

IDe. A-CTR Award mechanism and Total Cost • U 54 cooperative agreement • Up to $4 million per year for 5 years • Can request additional $300 K for A&R costs (year 1 only) Lead Institution • Academic Health Center • Only one application per state Partnerships • It is required to identify one or more collaborating domestic partner(s) within the state and in one other (or more) IDe. A state(s). Funding Opportunity Announcement: IDe. A-CTR (PAR-11 -229)

Component Activities of IDe. A-CTR Program Key Component Activities (Required) Recruitment of Clinical/ Translational Faculty Biomedical Informatics Resources Community Engagement and Outreach Ethics, Regulatory Knowledge and Other Partnerships and Collaborations within and across IDe. A-eligible states Clinical and Clinical Research Translational Pilot Design, Epidemiology, Grants Program and Biostatistics Core Clinical Research Resources and Facilities Clinical Research Education, Mentoring, and Career Development Core Potential Key Component Activities Technologies and Resources for Core Laboratories

IDe. A Networks of Biomedical Research Excellence (INBRE)

IDe. A Networks of Biomedical Research Excellence (INBRE) • • • To develop a statewide multi-disciplinary research network of doctoral degree-granting and undergraduate institutions To build and increase research capacity by supporting faculty, fellows and students at participating institutions To provide bioinformatics tools, training, and expertise for researchers and students across the network To provide undergraduate faculty and students research support, serve as “pipeline” to health research careers To provide outreach to students at undergraduate institutions, community colleges and tribal colleges To enhance statewide science and technology knowledge base

Model of INBRE PUI PI PC Other Cores Bioinfor. Core Outreach Institutions Tribal/Community Colleges Outreach Core Admin. Core PUI Lead Institution. Research Intensive Institutions or Institutes PUI = Primarily Undergraduate Institution

KANSAS-INBRE Organization SSC Hays Wichita State Univ. Pittsburg Kansas State Univ. Haskell Outreach ICs K-INBRE Emporia Lead IC Langston Washburn Kansas Univ. Lawrence Bioinformatics Cores • Data analysis of genomics, proteomics and lipidomics • Data storage and web access Building new strengths in Cell and Developmental Biology in the state of KS thereby paving new strategies to improve human health • Trans-disciplinary training in bioinformatics

Summary of INBRE Scientific Themes Microbiology and Infectious Disease Cell & Developmental Biology Cancer Neuroscience Biotechnology Environmental Health & Toxicology (EHT) Genetics & Genomics (GG) Cardiovascular Disease (CVS) Women & Reproductive Health (WRH) Bioinformatics (BI) Others (O) Diabetes/Obesity/Met abolism (DOM) Respiratory (Re) Mental Health & Biobehavioral research (MH) Bones/Joints (BJ) Immunology (Im) Hematology (H) Total 63 46 42 33 23 23 15 11 10 9 9 8 5 5 4 3 2

INBRE Progress In fiscal year 2011: • • • 24 INBRE Networks supported 658 research subprojects and 1808 investigators INBRE Networks published 610 research articles with 259 in press INBRE investigators made 2561 scientific presentations 69 INBRE flagship institutions supported 800+ students in summer research experiences INBREs supported research and training at 270 undergraduate institutions including: • 21 HBCUs • 17 Tribal Colleges and Universities • 21 Hispanic-serving institutions

IDe. A Community-Based Research

IDe. A Community Based Research (IDe. A CBR) Goals: • • To support development of sustainable, culturally appropriate prevention/intervention research programs to decrease the disproportionate burden of disease To develop effective and stimulating environments to facilitate training and development of clinical investigators in areas of health disparities and special populations

IDe. A CBR • • • To augment and strengthen translational / clinical community based research programs to address health disparities in rural and urban special populations To promote interdisciplinary, multi-site collaborations between academic researchers across programs, community health care providers, and community partners To leverage investments in CBPR made by NIH and other agency partners

Yup’ik Perceptions of Body Weight and Diabetes: Cultural Pathways to Prevention Yup’ik Experiences of Stress and Coping: Intervention Via Cultural Understanding Contaminants and Nutrients in Alaskan Subsistence Foods: Striking a Balance Developing a Novel Set of Diet Pattern Biomarkers Based on Stable Isotope Ratios http: //canhr. uaf. edu/

Environmental Health Science in Montana Analyzing river water and fish on the Crow Reservation to identify environmental contaminants - mercury - pesticides - enteric pathogens

IDe. A Co-funding

IDe. A Co-funding • IDe. A co-funds awards to support R 01 grant applications to NIH Institutes and Centers from investigators within IDe. A eligible states. • IDe. A provides support to applicants whose proposals received excellent ratings through the peer review process but fell short of the Institute’s or Center’s (ICs) pay line. • IDe. A provides 70% or up to $260, 000 for each of the first two years of a selected co-funded R 01 award. • This activity was highlighted in the NIH fiscal year 2012 appropriation language.

IDe. A Co-funding • Meritorious applications were solicited from the 27 NIH Institutes and Centers in fiscal year 2012. • IDe. A received 44 R 01 applications nominated from 18 NIH Institutes and Centers. • The total request for IDe. A co-funding amounted to $11. 1 million.

IDe. A Net

IDe. ANet Provides: • • • Advanced cyberinfrastructure for biomedical and behavioral research Regional approaches to relieve strategic bottlenecks in connectivity through participating states Access to national high-speed computer networks for dataintensive science applications • Computer hardware and software • Staff in bioinformatics cores and data centers

http: //www. loni. org/

Northeast Cyberinfrastructure Consortium (NECC) Multiple partnerships are formed between state university systems and private telecommunications companies to build regional high-speed networks in VT, NH, ME, RI and DE.

Cyberinfrastructure-Enabled Research and Training Ø A collaborative project for sequencing the skate genome was developed between U. of Delaware and Mount Desert Island Biological Laboratory (MDIBL). Ø Three training workshops of Skate Genome Annotation were performed through the network. The data are stored on server at the NECC shared data center at the U. of Delaware and U. of Maine, and available for investigators within the five NECC states. Ø Research training courses were provided to the first year medical students at MDIBL, Dartmouth Medical School and U. of Vermont College of Medicine. Skate genome sequence assembly and annotation project

Cyberinfrastructure-Enabled Science Education (Media Release) MDIBL participated Howard Hughes medical Institute’s Science Education Alliance Maine INBRE Newsletter The Bar Harbor Times

National Association of IDe. A Principal Investigators (NAIPI)

National Association of IDe. A Principal Investigators (NAIPI) Provides leadership and communication for the development, promotion and improvement of the IDe. A Program • Fosters interactions between the IDe. A Program and its constituencies • Promotes resource sharing among IDe. A programs • Enhances the visibility of the IDe. A Program • Develops a consensus on priorities and new directions for IDe. A • Identifies and disseminates best practices within the IDe. A Program • Identifies opportunities and develops strategies to achieve the common goals of the IDe. A Program

National Association of IDe. A Principal Investigators (NAIPI) • • Membership composed of Principal Investigators of INBRE and COBRE grants National Committee consists of 20 members, five for each of four Regional Divisions of IDe. A (2 INBRE and 3 COBRE Principal Investigators) National Committee members elected by voting members in each division Executive Committee consists of 4 members elected by the National Committee (President, Vice President, Past President and Secretary/Treasurer) • Working groups on an ad hoc basis • Web-site at http: //www. naipi. org

Selected Science Advances

Understanding the Role of Estrogen in Protecting Against HIV Dementia COBRE PI: Tom Curry, University of Kentucky College of Medicine Background: HIV-associated dementia (HAD) occurs in about 30% of all HIV-infected individuals despite aggressive anti-retroviral therapy. In vitro studies indicate that the hormone estrogen (17β-estradiol or E 2) acts as a neuroprotective agent by suppressing the production of HIV-encoded proteins by astrocytes. The role of estrogen receptors in this process is unclear. Advance: In vitro studies revealed that astrocytes have low levels of ERα expression. Surprisingly, the presence of ERα appeared to negate the reduction in HIV protein production that results from treatment with estrogen. Analysis of postmortem brain samples showed increased density of ERα-positive astrocytes in HIV-infected individuals with dementia compared to those without cognitive deficits. The data suggest that E 2 may have the most dramatic effect in reducing HIV transcription and acting as a neuroprotective agent early in the disease process when the subpopulation of astrocytes expressing ERα is low. How NCRR Grant Enabled Advance: NCRR COBRE grant (P 20 RR 18727), provided support to the research project and core facilities. Public Health Impact: Neurological complications are observed in about 60% of all HIV infected patients, dementia in about 30% despite anti-retroviral therapy. It is imperative that effective neuroprotective agents be developed if neurological complications of HIV are to be prevented. Publication Citation and Link: http: //www. ncbi. nlm. nih. gov/pubmed/19886840

Mechanisms of Plasticity and Repair after Spinal Cord Injury PI: Scott Whittemore Univ of Louisville School of Medicine Background: Multiple molecular, biochemical, and cellular events ensue following traumatic spinal cord injury (SCI). The prevention and/or attenuation of significant morbidity following SCI will require various neuroprotective strategies. Advance: Following experimental SCI, studies in rats indicate that transplantation of adult oligodendrocyte precursor cells (OPCs) that express ciliary neurotrophic factor (CNTF) resulted in histological, physiological, and functional evidence of recovery. Another study demonstrate that administration of rolipram, an investigational antiinflammatory agent, spared the death of oligodendrocytes, improved neurotransmission, and reduced hind limb errors during grid walking. In yet another study, the administration of agents that promote angiogenesis and endothelial cell survival had similar neuroprotective outcomes. How NCRR Grant Enabled Advance: NCRR COBRE grant (P 20 RR 15576), provided support to the research project and core facilities. Public Health Impact: Spinal cord injury (SCI) significantly impacts quality of life and poses a considerable economic burden on those afflicted. Restorative therapies need to be developed to reduce these burdens. Publication Citation and Link: http: //www. ncbi. nlm. nih. gov/pubmed/20181596 http: //www. ncbi. nlm. nih. gov/pubmed/20375135, http: //www. ncbi. nlm. nih. gov/pubmed/19635528

Community-Based Participatory Research in Indian Country PI: Margaret Eggers, M. S. , Little Big Horn College, Crow Agency, Montana; Montana State University, Bozeman Background: The poor well water quality and deteriorating river water quality are impacting community health. The occurrence of disease seems greater on the tribal reservation than in other communities. A collaborative research between Crow Reservation community and academic partners was initiated to assess the risk of exposure to contaminants via domestic and cultural water sources. Advance: Little is known about how communities and academic partners can effectively work together to conduct “community-based risk assessment, ” and rarely have Native American community members written about their perception of the value of the CBPR process to their community, why they would participate in such research, and how research should be conducted in their home community. The Crow Tribal and academic research partners describe their experiences and what they have learned in working together on a creative, collaborative CBPR project and process. How NCRR Grant Enabled Advance: The Montana INBRE provided initial research funding for the first five years of the project, and continues to support the well water testing costs. Public Health Impact: This project provides an example of how community members can initiate a risk assessment research in collaboration with academic partners. The partnership improves the quality of the risk assessment and the effectiveness of dissemination to community members. Publication Citation: . Community-based participatory research in Indian country: improving health through water quality research and awareness. Fam Community Health. 2010 Jul-Sep; 33(3): 166 -74.

Institutional Development Award Program Opportunities for Inclusion