The idea of a Haplotype Beyond Haploid H
The idea of a Haplotype Beyond Haploid
H. sapiens <100, 000 yrs. ± 4000 generations *Few recomb. /gen. *Haplotypes are of significance
Chauvet cave, 30, 000 BC Homo sapiens
H. sapiens 100, 000 yrs. ± 4000 generations *Few recomb. /gen. *Haplotypes are of significance
H. sapiens <100, 000 yrs. ± 4000 generations *Few recomb. /gen. *Haplotypes are of significance
Essentially Haploid: Haplotypes WITHOUT recombination
Note: In humans, the mutation rate is ± 10 -8 (per generation per bp) Y chromosome is 60 Mbp, so +/- 0. 6 bp change/generation Remember: For Y, recombination is NOT AN ISSUE 100000 years =± 4000 generations = D 2400 bp 3500 years =± 140 generations = D 90 bp
Y- haplogroup distributions now
Note: In human mitochondria, the mutation rate is ± 10 -5 (per generation per bp) Mitochondrial genome is about 17, 000 bp, so +/- 0. 2 bp change per generation Here too: For Mitochondrial DNA, recombination is NOT AN ISSUE
Note: In human mitochondria, the mutation rate is ± 10 -5 (per generation per bp) Here too: For Mitochondrial DNA, recombination is NOT AN ISSUE
The idea of a Haplotype
For AUTOSOMAL inheritance and haplotypes, we must address: -diploidy -crossovers/recombinant chromosomes *Additional levels of complexity
For Autosomes: Two alleles of each gene 127 c. M For Autosomes: crossovers and recombinant chromosomes
Take into account the dynamics/timing of: -single base pair changes -crossovers/recombinant chromosomes
For AUTOSOMAL inheritance and haplotypes, we must address: -diploidy -crossovers/recombinant chromosomes Prof. Rosie Redfield, UBC -Link to movie is on Moodle
- Slides: 29