The heme exporter Flvcr 1 regulates expansion and

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The heme exporter Flvcr 1 regulates expansion and differentiation of committed erythroid progenitors by

The heme exporter Flvcr 1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation by Sonia Mercurio, Sara Petrillo, Deborah Chiabrando, Zuni Irma Bassi, Dafne Gays, Annalisa Camporeale, Andrei Vacaru, Barbara Miniscalco, Giulio Valperga, Lorenzo Silengo, Fiorella Altruda, Margaret H. Baron, Massimo Mattia Santoro, and Emanuela Tolosano haematol Volume 100(6): 720 -729 June 1, 2015 © 2015 by Ferrata Storti Foundation

Flvcr 1 a and Flvcr 1 b deficiency affects the expansion and differentiation of

Flvcr 1 a and Flvcr 1 b deficiency affects the expansion and differentiation of murine committed erythroid progenitors. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Hematologic parameters of Flvcr 1 afl/fl ; Mx-cre mice. . Sonia Mercurio et al.

Hematologic parameters of Flvcr 1 afl/fl ; Mx-cre mice. . Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Flvcr 1 a/1 b morphants have defective erythropoiesis. Sonia Mercurio et al. Haematologica 2015;

Flvcr 1 a/1 b morphants have defective erythropoiesis. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Flvcr 1 a and Flvcr 1 b are required to rescue erythropoiesis in Flvcr

Flvcr 1 a and Flvcr 1 b are required to rescue erythropoiesis in Flvcr 1 a/1 b morphants. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Flvcr 1 a morphants are anemic. Sonia Mercurio et al. Haematologica 2015; 100: 720

Flvcr 1 a morphants are anemic. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Silencing of FLVCR 1 a or FLVCR 1 a/1 b in K 562 cells

Silencing of FLVCR 1 a or FLVCR 1 a/1 b in K 562 cells differentially affects proliferation and differentiation. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Inhibition of heme synthesis rescues anemia in Flvcr 1 a morphants. Sonia Mercurio et

Inhibition of heme synthesis rescues anemia in Flvcr 1 a morphants. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Supplementation with heme rescues anemia in Flvcr 1 a/1 b morphants. Sonia Mercurio et

Supplementation with heme rescues anemia in Flvcr 1 a/1 b morphants. Sonia Mercurio et al. Haematologica 2015; 100: 720 -729 © 2015 by Ferrata Storti Foundation

Heme Exporter FLVCR 1 a Regulates Heme SynthesisHeme Exporter FLVCR 1 a Regulates Heme Synthesis
The heme exporter Flvcr 1 regulates expansion andThe heme exporter Flvcr 1 regulates expansion and
Heme metabolism Structure of heme Heme is aHeme metabolism Structure of heme Heme is a
Les cgeps exporter la formation cest bien exporterLes cgeps exporter la formation cest bien exporter
Erythropoiesis RBC production Hemoglobin heme globin Heme aErythropoiesis RBC production Hemoglobin heme globin Heme a
HEME CATABOLISM Prof Dr Arzu SEVEN HEME CATABOLISMHEME CATABOLISM Prof Dr Arzu SEVEN HEME CATABOLISM
Erythropoiesis RBC production Hemoglobin heme globin Heme aErythropoiesis RBC production Hemoglobin heme globin Heme a
Metabolism of heme Alice Skoumalov Heme structure aMetabolism of heme Alice Skoumalov Heme structure a