The function of the human genome UCSC browser

The function of the human genome

UCSC browser

21. 000 protein coding genes. 45% of human genome: repetitive sequences.

21. 000 protein coding genes. 45% of human genome: repetitive sequences. 95% genes are subject of alternative splicings.

21. 000 protein coding genes. 45% of human genome: repetitive sequences. 95% genes are subject of alternative splicings. Many genes have more than one promoter 11% genes have bidirectional Promoters. Divergent and convergent.

21. 000 protein coding genes. 45% of human genome: repetitive sequences. 95% genes are subject of alternative splicings. Many genes have more than one promoter 11% genes have bidirectional Promoters. Divergent and convergent. Conservation of cis-Regulatory Elements (CREs) in mammals. 481 UCE (Ultra Conserved Elements) 100% identical in mammals.

21. 000 protein coding genes. 45% of human genome: repetitive sequences. 95% genes are subject of alternative splicings. Many genes have more than one promoter 11% genes have bidirectional Promoters. Divergent and convergent. Consevation of cis-Regulatory Elements (CREs) in mammals. Regulation. 481 UCE (Ultra Conserved Elements) 100% identical in mammals. Non coding RNAs: >10. 000. Micro. RNAs: >800.

Evoluzione del concetto di gene

Sieper and Arbiza. Cis-Regulatory Elements and human evolution. COGD 2014

How to locate binding of Transcription factors to the genome Ch. IP on chip (2003 -2008) 2008 - NEXT GENERATION SEQUENCING

From “READS” to peaks Hoffman B G , and Jones S J M J Endocrinol 2009; 201: 1 -13

Chromatin state maps E S. Lander. Nature 470, 187 -197 (2011)

Functional genomics: The ENCODE Project Ch. Ip-Seq location analysis in n (10/20) cell types of n (10/20) histone PTMs n (>300) Transcription Factor, Cofactors, DNA-binding Proteins DNA-methylation patterns.