The do TERRA Difference Start lots of challenges

The do. TERRA Difference! • Start - lots of challenges and difficulties – reposition and define what an EO was. • Told by experts that it was impossible to get pure oils for the 100 oils they wanted! • CPTG and Co impact sourcing define the • doterra difference

The do. TERRA Mission • Move essential oils into the mainstream – Research, purity and education • do. TERRA is science focused, nothing is left to chance • Have a physician advisory board of doctors

do. TERRA Scientific Team doterra. com/our company/about us/science • Dr Hill (Chiropractor)- Founding Executive, Chief Medical Officer / Chairman, Scientific Advisory Committee well known expert in essential oils and integrative medicine • Dr Parker (Ph. D. in Nutritional Sciences) – He oversees Research & Development and Quality Control. Worked in supplement industry and in academia - published many scientific papers. • Dr. Beaumont (Ph. D. in Medicinal Chemistry) - oversees all analytical laboratory testing and Quality Control activities - over 12 years of analytical experience

do. TERRA Scientific Team • Alexandrea Paul - MA and MPhil degrees in ecology and environmental and evolutionary Biology- with a focus on medicinal plants- Masters in Botany on the medicinal uses of citrus. • Nicole Stevens – M. S. - Botany and Integrative Biology -Research and Development Scientist • Dr. Han Ph. D. - in Bioscience - primary focuses on Molecular Genetics and Cell Biology - Clinical Research Scientist, Research and Development. He leads various clinical and pre-clinical research projects, including products and ingredients efficacy and safety studies.

Scientific Advisors • Robert Pappas, Ph. D - Physical Chemistry. He specializes in analytical testing services for flavour, fragrance, and essential oil/aromatherapy industries. Robert developed the first aromatherapy course to be offered for college credit in the US as well as a course on the chemistry of essential oils. • Brian Lawrence, Ph. D. - pharmacognosy • Technician and as a chromatography lab manager in the pharmaceutical industry. Researcher and the director of research and development. He has published in excess of 80 original articles and reports. Also published 13 books and 18 book chapters on essential oils. In 1989, he founded the Journal of Essential Oil Research and was editor-in-chief until January 2010. He remains on the JEOR editorial board.

Scientific Advisors cont… • Dominique Baudoux, Ph. D. Aromatologist pharmacist, aromatherapy expert, writer, research director, and internationally renowned speaker, Dr. Dominique Baudoux is one of the world's top essential oil experts.

Medical Advisory Panel Dr Hill Dr. Paul Winterton, MD - serves on the Board of Councillors for The American Academy of Orthopaedic Surgeons. He is currently researching the basic science, cell biology, and clinical application of essential oils. Dr. David Steuer, DMD, MS, MMs. C

Medical Advisory Panel cont… Dr. James Geiger, MD - anaesthesiologist since 1986. Also been an aromatherapist since 2004 gives lectures and webinars on the safe use of essential oils in hospitals and surgical centres to improve patient care. Currently, he is on staff at several medical centres, orthopaedic hospitals and surgical centres, where he has introduced therapy with essential oils into the operating and recovery rooms.

Medical Advisory Panel cont… Dr. Joshua Yorgason, MD - an ear, nose and throat surgeon. While in practice for the past five years, he has been supportive of alternative medicine, and has used essential oils in his practice. Dr. Jessica L. M. Herzog, MD, FAAP, ABHIM certified Holistic Integrative Medicine physician and paediatrician

Medical Advisory Panel cont… Dr. Brannick Riggs, MD – has been practicing medicine for 13 years. He specializes in Family medicine and is a member of the American Academy of Family Physicians. Dr. Gregory L. Woodfill, D. O. Obstetrician and Gynaecologist – He studies the safe and effective use of essential oils and direct research for the advancement of essential oils in professional health-care settings and home use. He provides education for many health-care providers

Partner research • 1. Partners with physicians and hospitals around the world. defining and establishing the medical integration and use of essential oils in modern health practices. • 2. He fosters education and advances in essential oil science through a number of university and research affiliations providing cutting edge science for essential oil users.

Ingestion • Internal – in Capsules; They are absorbed into systemic circulation via the digestive tract. Generally considered the most potent method of application • Oral – Under the tongue – localised, then systemic • Both methods are absorbed very quickly and are fast acting

Ingestion Cont. …. • Controversy – due to lack of awareness • Years of past and ongoing research - internal usage is safe and very effective doterra science blog • Food and Drug Administration’s (FDA -GRAS) • Affirms the safe use of essential oils as flavouring agents and preservatives

Oral - process • Mucous membranes lining the respiratory and digestive tracts – produce a variety of protective substances e. g. Mucin • Mucin produces a gel like substance, Mucus • The Mucus acts as a protection and transporter

Oral cont. . . • Research has shown that lipophilic substances bind to certain regions of mucin • Essential oils are lipophilic substances • After binding to mucin, they will travel through the digestive tract until they are absorbed into the blood stream.

Oral cont. . . • Oils first have an effect on local tissues • The local effect may be felt more strongly compared to skin (more mucosa nerves & closer) • essential oils contact the mucosa –Some absorption at initial point of contact – much of oil is continually diluted

Damaging to Mucous? • Studies suggest just the opposite • Many studies show – Eos- positive effect when there is a problem with the stomach’s mucous membranes; limonene, found in citrus oils, was shown to help protect the stomach mucosa. See doterra science blog

Effect of EO on Mucous Membranes • Several Eos increase digestive tract mucus production; e. g. d-limonene is a terpene found in several citrus oils including, Grapefruit, Lemon, Lime and Orange. • In digestive tract = a good thing – increased protection for underlying mucous membrane

Effects Cont. …. . • Mucus production in the respiratory tract must be more balanced to avoid congestion • Some essential oils have been shown to balance the production of mucus by regulating mucin genes; Lavender and Eucalyptus

Liver-primary site for EO metabolism • When the essential oil moves into the liver, specialized enzymes work to break down individual compounds into metabolites. These metabolites continue to circulate within the body before being eliminated, primarily in urine. Some exit via faeces, through the skin, or exhaled from the lungs

Oils to avoid ingesting • • Arborvitae Birch Cedarwood Cypress Eucalyptus White Fir Wintergreen

David E. Doxey - Director, Corporate Counsel • Currently – “In addition to great science, we also engage great legal and regulatory specialists, that are local to the U. K. . These legal and regulatory specialists ensure that dōTERRA’s products are correctly labelled, with safe use directions, that are compliant within the U. K. ”

David E. Doxey • Each product is reviewed against relevant U. K. laws to determine that the U. K. has accepted the oils as safe for use internally. • Customers should only consume oils that are labelled for internal consumption. • within weeks we should have 32 oils that are labelled for internal use • In the U. K. , the products will be labelled as food or a food additive label.

Helen Anderson- Corporate Counsel • EOs are safe when used as directed (see the label and Dr. Hill's usage guidelines) • EOs come from plants, many of which are obviously safe for internal use • Most of our internal-use EOs are on the GRAS list or something similar • There's little to no scientific research to support the critics

Helen Anderson- corporate counsel • If the concern is the effect of EOs on mucus membranes, mucus membranes are actually well-equipped to handle substances like EOs • We track adverse events and they are rare and usually minor

Helen – oils and children • Use less with children because they have lower body mass • Start with a single oil • Start with diffusion or topical application and dilute • Consult a health care professional before using internally

Helen – oils and children • Avoid eyes, ears, nose, and sensitive area • Keep out of reach of children • In the cases of toxicity reported in technical literature, EOs were not used as directed-doses well above what we recommend, inside nose, etc.

Kevin Jenson MS, BS Senior Technical Writer - Science • Liver? http: //doterra. com/US/en/blog/safetyphysiology-essential-oil-metabolism • “What we’ve published so far has stopped the aromatherapists in the US from going after us hard. If the aromatherapists in the UK have different arguments against internal use, I will be happy to write more do. TERRA Science articles to placate their specific concerns. ”

Murray Smith Managing Director – Europe do. TERRA • The product labels and formulations are reviewed against the relevant regulations, including those provided by MHRA (Medicines & Healthcare products Regulatory Agencygov)

Essential oils in drinks! • Coke contains: Lemon, coriander, neroli, nutmeg and cinnamon essential oils • Many fizzy drinks contain citrus essential oils; Lemon, Lime and Orange

Peppermint Scare • Claim: Peppermint EO killed a 3 week old baby, Mathew Young (BBC) • Boots Pharmacist has made up the peppermint water so that it contained an excessive amount of chloroform. • Also called trichloromethane CHCl 3. Used chiefly in medicine as a solvent and formerly as an aesthetic.

ATC Guidelines • Never take essential oils internally, unless under the guidance of a qualified aromatherapist who has received the necessary training in this very specialised mode of administration.

Robert Tisserand interview • In December 2014 Robert Tisserand was interviewed by Labron Allen, a functional medicine nutritionist based in Texas, for his Health Alert radio show. • “I have never said you should not ingest essential oils. What I do believe is that you need to know what you’re doing. ”

Summary • Teach responsible usage – always follow daily amounts – teach to use the oils for ailments for short periods, not excessive use. • Start small and less when sick- listen to body • Remember – you don’t have to take them internally.