THE DIABETES HEALTH PROFILE DHP DEVELOPMENT JOURNEY The

THE DIABETES HEALTH PROFILE (DHP) DEVELOPMENT JOURNEY The DHP-1 and DHP-18 are standardised diabetes-specific measures of the impact of diabetes on psychological and behavioural dysfunctioning in Type 1 and Type 2 diabetes respectively. Compliant with FDA guidelines on PRO developments for label claims. 1986 Initial development of the DHP-1 Literature review + Patient input DHP Conceptual model 25 In-depth patient interviews

Through a combination of factor analyses, internal reliability, construct, convergent and discriminant validity the 32 -item DHP-1 conceptual framework is defined for Type 1 & Type 2 Insulin requiring patients. Compliant with FDA guidelines on PRO developments for label claims. • Meadows et al 1996; Qual Life Res; 5: 242 -254; Goddjin et al. 1996; Qual Life Res; 5: 433 -442 1986 -1996 DHP-1 Conceptual framework development

From the original 32 -item DHP-1 the 18 -item DHP-18 conceptual framework is derived for use with Type 1 and Type 2 diabetes including insulin, oral and diet. Compliant with FDA guidelines on PRO developments for label claims. • Meadows et al. Diabetic Med 2000; 17: 572 -580. 1996 -2000 DHP-18 Conceptual framework developed

More than Type 1 & Type 2 Respondents Have completed the DHP-1 / DHP-18 2000 -2013 Current & previous users of the DHP-1/DHP-18

An example of what the DHP-1/DHP-18 can tell us Source: Boini et al. Health and Quality of Life Outcomes; 2010; 8: 124 3173 Mean age 91% Type 2 and 9% Type 1 patients completed the questionnaire. Psychological distress MOST AT RISK Disinhibeted eating 63. 9 years 55% 45% Psycholigical distress Insulin Barriers to activity Oral Patients (mean) scores on the Disinhibited eating domain by BMI <25 BMI 25 -34 BMI >35 47, 2 52, 2 57, 2 Score 0=No dysfunctioning p<0. 05 100% 90% 80% 70% 60% • Comorbidity 50% • Severe hypoglycaemia 40% • Female • > Age • Visit to the pyschiatrist Patients reporting severe hypoglycaemic episodes 30% 47. 8 20% 49. 2 ANOVA p=0. 05 10% 52. 4 0% 35 -44 45 -54 55 -64 65 -74 Psychological distress >75

Develops e. DHP 2013 New Developments Forthcoming research article Investigating the minimally important difference of the Diabetes Health Profile (DHP-18) and the EQ-5 D and SF-6 D in a UK diabetes mellitus population Diabetes Health Profile (DHP) Licensing Association with Clinical Outcomes. For further information on the Diabetes Health Profile visit www. diabetesprofile. com Email: info@dhpresearch. com Copyright DHP Research & Consultancy Ltd 2013. All rights reserved For licensing enquiries contact Clinical Outcomes Email: healthoutcomes@innovation. ox. ac. uk Tel: : +44 (0)1865 280830 https: //innovation. ox. ac. uk/clinical-outcomes/