The Complement Cascade The Terminal Pathway Complement The

Complement: The Terminal Pathway C 3 a C 3 b is the first component

Complement: The Terminal Pathway C 3 b C 5 b C 5 a C

Complement: The Terminal Pathway C 5 b C 6 C 5 b binds to

Complement: The Terminal Pathway C 5 b. 6 C 5 b binds to C

Complement: The Terminal Pathway C 5 b. 6 C 7 C 5 b. 6

Complement: The Terminal Pathway C 5 b. 6. 7 C 5 b. 6 binds

Complement: The Terminal Pathway C 5 b. 6. 7 C 8 C 5 b.

Complement: The Terminal Pathway C 5 b. 6. 7. 8 C 5 b. 6.

Complement: The Terminal Pathway C 5 b. 6. 7. 8 C 9 C 9

Complement: The Terminal Pathway C 5 b. 6. 7. 8. 9 n C 5

Complement: The Terminal Pathway ¨ The following slides are a graphical illustration of the

Complement: The Terminal Pathway cell membrane pathogen

Complement: The Terminal Pathway End of Presentation The Membrane Attack Complex

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The Complement Cascade The Terminal Pathway

Complement: The Terminal Pathway C 3 a C 3 b is the first component of the Terminal Pathway

Complement: The Terminal Pathway C 3 b C 5 b C 5 a C 3 b cleaves C 5 producing C 5 a and C 5 b Next

Complement: The Terminal Pathway C 5 b C 6 C 5 b binds to C 6

Complement: The Terminal Pathway C 5 b. 6 C 5 b binds to C 6 Next

Complement: The Terminal Pathway C 5 b. 6 C 7 C 5 b. 6 binds to C 7

Complement: The Terminal Pathway C 5 b. 6. 7 C 5 b. 6 binds to C 7 Next

Complement: The Terminal Pathway C 5 b. 6. 7 C 8 C 5 b. 6. 7 binds to C 8

Complement: The Terminal Pathway C 5 b. 6. 7. 8 C 5 b. 6. 7 binds to C 8 Next

Complement: The Terminal Pathway C 5 b. 6. 7. 8 C 9 C 9 C 9 C 5 b. 6. 7. 8 binds 12 -15 molecules of C 9 to form the Membrane Attack Complex

Complement: The Terminal Pathway C 5 b. 6. 7. 8. 9 n C 5 b. 6. 7. 8 binds 12 -15 molecules of C 9 to form the Membrane Attack Complex Next

Complement: The Terminal Pathway ¨ The following slides are a graphical illustration of the terminal pathway ¨ The end-point is the formation of the membrane attack complex which punches a hole in the bacterial membrane. ¨ This loss of membrane integrity results in the death of the bacteria • The graphics run automatically Next

Complement: The Terminal Pathway cell membrane pathogen

Complement: The Terminal Pathway C 5 b

Complement: The Terminal Pathway C 6

Complement: The Terminal Pathway C 7

Complement: The Terminal Pathway

Complement: The Terminal Pathway C 8

Complement: The Terminal Pathway C 9

Complement: The Terminal Pathway

Complement: The Terminal Pathway End of Presentation The Membrane Attack Complex