The Centre for Process Innovation Wilton Redcar www

The Centre for Process Innovation Wilton, Redcar www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

The Strategy for Success www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Features of the CPI vision • A National Resource – World-class, internationally recognised – Regional and UK Plc agenda – Scope - base, speciality, fine, pharmaceuticals, downstream • Collaborative applied research and development – Market/Industry led – Incremental build of skills, knowledge, facilities and capability – Multi-company or one-on-one • Manufacturers • Catalyst producers • Technology developers/suppliers – Universities: regional, national and international www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

So …. . • We’re here to reduce the barriers to innovation by – sharing risk, providing facilities, resources, and knowledge • We’re a company limited by guarantee – we can’t make and distribute a profit • We do not provide money…… – We’re not a government grant agency • We’re about action…we’re here to do things – With confidentiality assured • We want a (small) share of the action – To cover costs and make us self-sustaining • We recruit the Best Talent available – Work as a Team www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Strong Industry Involvement www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

How CPI works Demand Thrusts Platforms Programmes Science Base Industry/Market Demand Advanced Processing & Manufacturing Functional Materials Supercritical Fluids Company Electronic Polymers Company n Collaborators Universities Technology Advisory Committee – oversees agenda and advises on relevance and quality Academic links will be stimulated by part-sponsorship of chairs/post-docs/joint programmes www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Fuel Cell Applications Facility • Objective: create a fuel cells cluster in the Tees Valley • Static applications – Supply security and fuel efficiency main drivers – Demonstrator projects • Significant Involvement – Du. Pont, Huntsman, Johnson Matthey*, BOC, Air Products*, Terra Nitrogen, Norsk Hydro, Black & Decker – Intelligent Energy*, Fuel Cells UK*, DTI, Carbon Trust, Canadian Research Council, US Department of Energy • Progress is substantial – 3 demonstrators in place, 2 more planned – Targeting € 2. 8 bn European funding ………enabling a supply chain www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Polymer Electronics • Collaboration with Du. Pont Teijin Films – – Initial project on the Functional Materials Platform Objective is to develop luminescent polyester films for displays “Disruptive Technology” Development facility at CPI • Progress – £xm project – DTF/CPI contract executed • Potential consortium members – Xaar, Avecia, ICI, Du. Pont Teijin, Du Pont Displays, Kodak, Plastic Logic, Cambridge Displays, Philips, University of Durham – UK Plastic Electronics Manufacturing Facility potential ………Building a new industry www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Functional Materials Platform • Focused on developing new products – Significant number of opportunities – Challenge is not to get distracted! – Many companies interest in molecular level effects but common agenda needs to be defined • Advanced Functional Materials Centre Proposal – £x. M application to DTI – £x+M matched by Industry – Links with University of Durham, White Rose Nano-factory and others ………Exploiting material properties www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Business Development • Offers leading edge support and Technology Transfer to industry – – Facilitating improvement by sharing Best Practice Pilot plant equipment brokerage Specialist consultancy services Direct support to 40+ SMEs • Relationships with Universities – Possible sponsorship of chairs • Newcastle for Chemical Engineering • Durham for Chemistry – Encouraging collaborations between Universities – Interdisciplinary Research Centre in Polymer Science – Support to spin-outs and start-ups ………leveraging knowledge www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Bio-Processing • Centre of Excellence in Bio-catalysis, Biotransformations and Bio-catalytic Manufacturing – Co. EBio 3 – – – Focused on high value fine chemicals and pharmaceutical intermediates Pro-Bio, EPSRC and DTI supported initiative led by Prof Roberts from University of Manchester £ 20 m project over 5 years Core academic research at Manchester plus York & Heriot-Watt £ 2. 5 m capital pre-manufacturing scale up facility at CPI • 20 + companies interested including: – Astra. Zeneca, GSK, Johnson Matthey, Angel Biotech, BASF – 15 already signed up as of 01/12/04 ………developing new ways to make things www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Supercritical Fluids Processing • A new processing route – – Enables highly selective chemistry Of interest to control particulate formulation Novel process fluid e. g. water Can be used to make a wide range of molecules • Developing collaborative project with several companies, Nottingham University, Newcastle University and others – – Pre-competitive generic development – creating IPR for the partners Initial programme focusing on water £xm project Future one-to-one programmes with other collaborators – catalysis, hydrogenation ………developing new ways to make things www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Batch to Continuous Processing • Significant opportunity: – Cost pressures as margins squeezed – Process & Analytical Technology (PAT) Initiative brings whole pharmaceutical industry into play • 4 consortia running or being established: – 5 companies working together with a university based technology for novel reaction systems – Several companies coming together with CPI to look at heatexchange reaction systems – Bioreactor consortium is under development – A consortium is under development to look continuous precipitation and crystallisation options ………developing new ways to make things www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Advanced Processing Platform • Focused on manufacturing routes – – More with less – increase capital intensity and variable cost efficiency Increasing speed of development of new processes Only making the molecules you want & reducing by-products “Green” processing • Vision is to systematically create a multi-purpose demonstration capability: – 80: 20 concept – non-optimised, proof of concept – Multiple feedstock and types – Reaction system options coupled with separation & purification www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Business Intensification by Advanced Processing Water SCF Solvent Feed React Separation+ Product Handling www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Business Intensification by Advanced Processing Enzyme Frisky Slow, well mixed Generic e. g. Fermentor e. g. Heat exchanger reactor e. g OBR CSTR www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Business Intensification by Advanced Processing A---->B---->C---->D B A B 2 C D www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Speeding the adoption of new technologies • Develop and demonstrate putative processes • Produce trial quantities of product • Demonstrate whole process • Assess and mitigate commercial case and risk www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd

Thank You www. uk-cpi. com © & Confidential to The Centre for Process Innovation Ltd