The Blackfynn Data Management Platform Enabling datacentric collaboration

The Blackfynn Data Management Platform: Enabling data-centric collaboration for the CBTTC Amanda Christini, MD Chief Operating Officer Blackfynn, Inc CBTTC Investigator/Foundation Meeting, May 25, 2016

One in six people worldwide has a neurologic disease that has no effective treatment. Blackfynn’s Data Management Platform integrates complex scientific and clinical data to enable the development of lifesaving therapeutics for neurologic disease.

The Blackfynn Platform: Accelerating Science and Medicine Transformative science relies on teams of interdisciplinary experts that collaborate to understand analyze data. Blackfynn’s Platform enables these fundamental goals. Built by a neurologist, computer scientist, neuroscientist and physician entrepreneur from Penn to change how neuroscience research is done.

The Blackfynn Platform: Accelerating Science and Medicine Upload View Integrate Search Collaborate Analyze

The Blackfynn Platform reads and manages data and metadata of all forms Drag and drop via browser or batch direct via S 3 Automatic data conversion pipelines Raw data can be viewed, annotated, analyzed, shared No forced ontologies; automated metadata detection Links to and improves existing workflow & systems Ingests streaming data from devices

The key to discovery of predictive patterns: linking and integrating data across modalities Link data elements automatically Data types, longitudinal data Search relationships Leverage analytic pipelines Elucidate disease mechanism Identify novel biomarkers

Facilitate data-centric collaboration Annotate and share data Unlock siloed data across teams Collaborate from anywhere Get an expert opinion Accelerate research discovery, validation, translation

Applications of the Blackfynn Platform AMCs and Consortia Therapeutic drugs Enterprise-level Data Commons Data-driven patient engagement Clinical care Empower data across teams Elucidate mechanisms Validate novel combination biomarkers Patient stratification Patient engagement and data access Therapeutic / Diagnostic Devices Develop & test algorithms Deploy responsive devices

The Blackfynn Platform supports CBTTC goals: Data empowerment and collaboration Initial focus on pathology images & metadata, tapping expertise across sites WSI can be viewed in web-based browser, annotated and shared with colleagues Viewing capabilities: zoom, scroll, slide tray, side-by-side with slides, reports, MRI Annotate using flags & free draw linked to searchable free text Send URLs to colleagues securely for consultative review Available to all CBTTC members June 2016

Rapid, nimble slide review: Zoom, pan, slide tray, side-by-side comparison

Simultaneous review of key data

Intuitive annotation tools & provenance tracking

Data-centric collaboration leverages experts across sites

Next steps with the CBTTC: Blackfynn Platform to broadly support CBTTC-related data and research Refine tools and add analytics for pathology Expand to cover a broader suite of data modalities Links into messaging tools and existing workflows / systems Work closely with users and stakeholders to define and implement these rapidly

Aims of Pathology User Testing Session Terrace Room, 12: 30 30 minutes with CBTTC pathologists and other key stakeholders Platform demo User design session focused on problems, needs and user feedback

Questions? amanda@blackfynn. com