The architecture of neoplastic follicles in follicular lymphoma Slides: 7 Download presentation The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T cells by William Townsend, Marta Pasikowska, Deborah Yallop, Elizabeth H. Phillips, Piers E. M. Patten, Jonathan R. Salisbury, Robert Marcus, Andrea Pepper, and Stephen Devereux haematol Volume 105(6): 1593 -1603 June 1, 2020 © 2020 by Ferrata Storti Foundation Distribution of CD 4 pos PD-1 pos ICOSpos cells in normal germinal centers and follicular lymphoma. William Townsend et al. Haematologica 2020; 105: 1593 -1603 © 2020 by Ferrata Storti Foundation Close physical association between Ki 67 pos B cells and follicular helper T cells in normal germinal center light zones. William Townsend et al. Haematologica 2020; 105: 1593 -1603 © 2020 by Ferrata Storti Foundation Ki 67 pos cells are in close proximity to follicular helper T cells (TFH) in follicular lymphoma lymph nodes. William Townsend et al. Haematologica 2020; 105: 1593 -1603 © 2020 by Ferrata Storti Foundation Association between Ki 67 and number of follicular helper T cells in follicular lymphoma. William Townsend et al. Haematologica 2020; 105: 1593 -1603 © 2020 by Ferrata Storti Foundation Close contact between Ki 67 pos cells and follicular helper T cells in follicular lymphoma: evidence for immune synapse formation. William Townsend et al. Haematologica 2020; 105: 1593 -1603 © 2020 by Ferrata Storti Foundation Evidence of T-cell receptor repertoire restriction in follicular lymphoma. William Townsend et al. Haematologica 2020; 105: 1593 -1603 © 2020 by Ferrata Storti Foundation Cerebriform nucleiNeoplastic proliferation of white blood cellsLichen sclerosus vulvareSecondary oocyte and ovumSecondary oocyteOvarian follicleFollicular conjunctivitisNodular goiter