The 5 year Survival Rate for a Glioblastoma

The 5 -year Survival Rate for a Glioblastoma Tumor for the ages 20 -44 is… 17% With this small of a survival rate why are we not looking at different ways to treat brain tumors?

The Alternative Treatments for Brain Cancer MAYA TAKASHIMA MOUNT HEBRON HIGH SCHOOL KENNEDY KRIEGER INSTITUTE HERNANDO LOPEZ-BERTONI

Presentation Overview ● ● ● ● Why I am Interested My Internship What I do at my Internship My Research What I want to do with my Research Data Collection Final Product

Reasons of Interest ● Personal experience ○ Family Member ● Extreme interest in the Brain and Nervous System ● The fascination of the Brain

My Intership ● ● ● Location: Kennedy Krieger Institute (Research Building) Mentor: Hernando Lopez-Bertoni ● Neurologist A Day at my Internship: ● Lab Work ● ● Brain Tumor Stem Cells Passaging Cells DNA transfection Western Blot

My Research Question: What are alternative treatments for brain cancer? Hypothesis: There are different methods of treating brain cancer; there is the traditional method and the experimental method.

My Research ● ● ● Goal: Educate people on Traditional Treatments versus Experimental Treatments Traditional Treatments ● Chemotherapy ● Radiation Therapy Experimental Treatments ● Immunotherapy ● Novo. TTF-100 A ● Nanotherapy

Data Collection ● Meta-Analysis ○ Read, Analyzed, and Annotated the articles ○ Created a Data Chart ● Chemotherapy with alkylating agent, temozolomide, has been found to increase survival rate ● Immunotherapy needs more clinical trials, but has shown promising results ● Novo. TTF-100 A improves the quality of life, no increase in survival rate ● Radiation therapy after surgery shows no increased survival rate ● Nanotherapy doesn’t show increased survival rate, still very early to tell

Product ● A brochure ● Allows easy to read comparison of traditional treatments and experimental treatments ● The product will be given to the same presentation audience ● In a real world setting the target audience would be a group of patients

Conclusion A SURVIVAL RATE OF 5 YEARS DOES NOT HAVE TO REMAIN AT 17%; USING ALTERNATIVE TREATMENTS MAY HELP TO INCREASE THE 5 YEAR SURVIVAL RATE

Evaluate Product Please take a moment to evaluate the brochure: https: //www. surveymonkey. com/r/6 MYFMHP

Questions?

Works Cited Adult central nervous system tumors treatment. (2015, August 25). Retrieved February 22, 2016, from NIH: National Cancer Institute website: http: //www. cancer. gov/types/brain/patient/adult-brain-treatment-pdq Alice, P. (2015, January 22). Birth control pill risks may now include brain cancer. Retrieved December 9, 2015, from Time website: http: //time. com/3677129/birth-control-risks-may-include-brain-cancer/ Andrews, R. , (2015, November 10). Scientists have breached the blood-brain barrier for the first time and treated a brain tumor using an "ultrasonic screwdriver". Retrieved February 22, 2016, from IFL Science website: http: //www. iflscience. com/brain/ultrasonic-screwdriver-used-open-blood-brain-barrier-treattumor-first-time Brain cancer. (2014, May 26). Retrieved February 21, 2016, from University of Maryland Medical Center website: http: //umm. edu/health/medical/altmed/condition/brain-cancer Brain cancer patients short on valuable protein. (2004, March 20). Retrieved September 30, 2015, from Gale Power. Search website: http: //go. galegroup. com/ps/retrieve. do? sort=RELEVANCE&doc. Type=Article&tab. ID=T 003&prod. Id=GPS&search. Id=R 5&result. List. Type=RESULT_LIS T&search. Type=Basic. Search. Form&content. Segment=¤t. Position=6&search. Results. Type=Single. Tab&in. PS=true&user. Group. Name=hcpub_hebron&doc. Id= GALE%7 CA 115696788&content. Set=GALE%7 CA 115696788 Brain cancer risk factors. (n. d. ). Retrieved November 11, 2015, from American Brain Tumor Association website: http: //www. abta. org/brain-tumorinformation/risk-factors/ ? referrer=https: //www. google. com/ Brain tumor: Overview. (n. d. ). Retrieved December 2, 2015, from Cancer. net website: http: //www. cancer. net/cancer-types/brain-tumor/overview

Works Cited Cell phones and cancer risks. (2013, June 24). Retrieved November 18, 2015, from NIH: National Cancer Institute website: http: //www. cancer. gov/aboutcancer/causes-prevention/risk/radiation/cell-phones-fact-sheet Cell phones and risk of brain tumors: What's the real science? (2015, July 28). Retrieved September 9, 2015, from CNN website: http: //www. cnn. com/2015/07/28/health/cell-phones-brain-tumor-risk-berkeley/ Early cells in deadly brain cancer found. (2011, July 8). Retrieved September 23, 2015, from Futurity website: http: //www. futurity. org/early-cells-in-deadly-braincancer-found/ Evan, D. B. , Dr, Mabuchi, K. , Dr, Cullings, H. M. , Dr, Preston, D. L. , Dr, Kodama, K. , Dr, Shimizu, Y. , Dr, Shore, R. E. (n. d. ). Long-term radiation-related health effects in a unique human population: Lessons learned from the atomic bomb survivors of Hiroshima and Nagasaki. NCBI. http: //dx. doi. org/10. 1001/dmp. 2011. 21 Glioblastoma-Initiating cells: Relationship with neural stem cells and the micro-environment. (n. d. ). MDPI. http: //dx. doi. org/10. 3390/cancers 5031049 Kids may risk cancer from toxins in food. (2012, November 16). Retrieved October 20, 2015, from Futurity website: http: //www. futurity. org/kids-may-risk-cancerfrom-toxins-in-food/ Little, J. B. (2000). Radiation carcinogenesis. Carcinogenesis, 21(3), 397 -400. Muscat, J. E. , Malkin, M. G. , Thompson, S. , Shore, R. E. , Stellman, S. D. , Mc. Ree, D. , . . . Wynder, E. L. (2000). Handheld cellular telephone use and risk of brain cancer. Cellular Telephones and Brain Cancer, 284(23).

Works Cited Pearce, M. S. , Salotti, J. A. , Little, M. , Mc. Hugh, K. , Lee, C. , Kim, K. P. , . . . Berrington de Gonzalez, A. (2012). Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: A retrospective cohort study. Lancet, 380. http: //dx. doi. org/10. 1016/S 0140 -6736(12)60815 -0 Reilly, K. M. , Dr. (n. d. ). Brain tumor susceptibility: The role of genetic factors and uses of mouse models to unravel risk. NCBI. http: //dx. doi. org/10. 1111%2 Fj. 1750 -3639. 2008. 00236. x Ron, E. , Dr. (n. d. ). Tumors of the brain and nervous system after radiotherapy in childhood. The New England Journal of Medicine. http: //dx. doi. org/10. 1056/NEJM 198810203191601 Sarasua, S. , Ms. , & Savitz, D. A. , Dr. (n. d. ). Cured and broiled meat consumption in relation to childhood cancer. Cancer Causes & Controls. http: //dx. doi. org/10. 1007/BF 01830260 Schlehofer, B. , Blettner, M. , Becker, N. , Martinsohn, C. , & Wahrendorf, J. (1992). Medical risk factors and the development of brain tumors. Cancer, 69(10). Schull, W. , Norton, S. , & Jensh, R. (n. d. ). Ionizing radiation and the developing brain. NCBI. Symptoms and causes. (n. d. ). Retrieved January 6, 2016, from Mayo Clininc website: http: //www. mayoclinic. org/diseases-conditions/brain-tumor/symptomscauses/dxc-20117134 Yearly dental x-rays raise brain tumor risk, study finds. (2012, May 3). Retrieved October 7, 2015, from CBS News website: http: //www. cbsnews. com/news/yearly -dental-x-rays-raise-brain-tumor-risk-study-finds/