Testing Business ADx Testing Convenient online ordering report
Testing & Business ADx Testing • Convenient – online ordering & report delivery • Regulatory conformance – CLIA lab LDT • Market ready tests w national sales channel ADx Business • Target – Alzheimer’s risk reduction & healthcare management • Leverage – Healthcare science 2 a & in-house expertise to deliver lab results & therapeutic recommendations • Integrate – Lab reporting w value-added, telehealth patient healthcare options
Geno. Risk TM Polygenic Risk Score A conditional genetic risk assessment of non-familial Alzheimer’s disease* Saliva-based test converted to probability score via algorithm model *SNP inclusion based on a case control study from the Alzheimer’s Disease Genetics Consortium. Candidate statistical models were run to confirm best fit model based on a 10 -fold cross validation baseline. An elastic net model is used (Brier score 0. 207). Population distribution & mean and median population values derived via a 1000 Genomes sample set, including 26 ethnically diverse populations. The presented conditional lifetime score is weighted based on age and gender and assumes an onset age of 85. ADx HEALTHCARE PROPRIETARY
Additional Test Products & Services Via owner-partner CLIA lab Bellingham, WA • Plasma-based cf. DNA biomarker assay specific to AD • Comprehensive patient and physician lab and therapeutic protocol report • Automated, online patient and physician reporting
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