Technologies for Transradial PCI An Overview of Boston

Technologies for Transradial PCI An Overview of Boston Scientific Current and Pipeline Technology Craig A. Thompson, M. D. , MMsc. Senior Vice President Chief Medical Officer Interventional Cardiology and Structural Heart Boston Scientific

Disclosures • Employee – Boston Scientific Corporation • Stock – Boston Scientific Corporation

Product Pipeline Details SENTAI™ Guidewires Frontline MARVEL™ SAMURAI™ Specialty Crossing SAMURAI™ RC FIGHTER™ HORNET™ 10 HORNET™ 14 © Boston Scientific Corporation. All Rights Reserved. IC-350809 -AA OCT 2015 2 of 9

SENTAI MARVEL™ and SAMURAI™ Guidewires Coil Length(17 cm) / Hydrophilic Coating Radiopaque (3 cm) 0. 014 inch MARVEL™ Hydrophilic 4. 5 g Coating PTFE Coating Coil Length(20 cm) / Hydrophilic Coating Radiopaque (4 cm) 0. 014 inch 10 mm Lubricity moderated 4. 5 g Hydrophilic Coating PTFE Coating IC-375101 -AA FEB 2016 Manufacturer: Boston Scientific

SENTAI FIGHTER™, SAMURAI™ RC and HORNET family Guidewires FIGHTER™. 009” Tapered Tip Load: 1. 5 g HORNET™ 10 SAMURAI™ RC Inner Coil Technology Tip Load: 1. 2 g IC-375101 -AA FEB 2016 HORNET™ 14 . 008” Tapered Tip Loads: 1 g, 10 g, 14 g

GUIDEZILLA™ 5 F-in-6 F Guide Extension Catheter § 5 -in-6 F (1. 67 in 2. 00 mm) device § ID: 0. 057” (1. 45 mm) / OD: 0. 066” (1. 68 mm) § 145 cm overall length with 25 cm guide catheter segment § 120 cm proximal hypo tube shaft § To be used in conjunction with guide catheter to access discrete regions of the coronary to facilitate placement of devices § Hydrophilic coating IC-375101 -AA FEB 2016 § 1: 1 stainless steel flat braid (catheter)

NC Emerge™ Post-dilatation PTCA Balloon § 5 F (1. 67 mm) compatible § 0. 017”/ 0. 43 mm lesion entry profile § 20 atm (2026. 5 k. Pa) Rated Burst Pressure for 2. 0 mm 4. 0 mm diameter balloons; 18 atm (1823. 85 k. Pa) RBP for 4. 5 mm – 6. 0 mm diameter balloons § Bi-Segment inner shaft combines a flexible distal segment with a pushable proximal segment § Improved Simultaneous Use* (allows 2 Monorail™ Available balloon lengths (mm) 6, 8, 12, 15, 20, 30 Available balloon diameters (mm) 2. 00, 2. 25, 2. 50, 2. 75, 3. 00, 3. 25, 3. 50, 3. 75, 4. 00, 4. 50, 5. 00, 5. 50, 6. 00 *Compared to NC Quantum Apex. Bench and preclinical testing has shown that one 4. 00 x 30 mm (or smaller) and one 3. 25 x 20 mm (or smaller) Monorail balloon catheters can be inserted simultaneously into a 6 F (minimum 0. 070 in ID) guide catheter. These tests did not account for all clinical situations and differing anatomy. Care should be used when attempting to use two balloon catheters simultaneously in a guide catheter; this technique was not clinically evaluated for safety and effectiveness in a clinical trial. Balloon catheters with a diameter greater than those mentioned have not been tested for simultaneous use in a single guide catheter. IC-375101 -AA FEB 2016 catheters in a 6 F GC)

OPTICROSS™ Coronary Imaging Catheter § 5 F (1. 67 mm) guide compatible § 40 MHz IVUS catheter § Short tip to transducer distance, facilitating better visualization of distal anatomy § Single transducer rotates on a drive shaft at 1, 800 RPM § Bioslide™ hydrophilic coating on tip connection for improved ease of use and reduced potential for connection error Data on file at BSC IC-375101 -AA FEB 2016 § Opti. Cross Motor Drive Unit (MDU)

COMET™ Pressure Guidewire ASAHI + Boston Scientific design and technologies Laser-cut Hypotube Asahi Tip and coating Optical Pressure Sensor Key Features Precise Torque Response Provides exceptional torque response in tortuous anatomy Optimal Tip Flexibility and Transition Enables gradual stiffness transition for maximum control IC-346311 -AA POLARIS Pipeline Deck Durable Tip-shape Retention Dual-coil is designed to maintain tip share for vessel selectivity and catheter positioning.

HOME Trapping Balloon Wire stabilization for OTW system exchanges

Mamba™ Microcatheter Novel Stainless Steel Coil Construction Provides Remarkable Flexibility & Torqueability 2. 1 F Distal Profile Improved Wire Follow Improved Tip Robustness Discreet 2 mm Tip Marker Extremely Lubricious and Durable Hydropass Coating

THREADER™ Micro-Dilatation Catheter § Powercoil Technology § 0. 017” (0. 43 mm) lesion entry profile § 0. 024” (0. 61 mm) crossing profile § 1. 2 mm x 12 mm semi-compliant balloon § 150 cm effective length § Threader OTW enables contrast injection § To combine pushability of a hypotube with the flexibility and kink resistance of polymer catheter shafts IC-375101 -AA FEB 2016 § Available in both Monorail & OTW

STINGRAY™ LP CTO Coronary Re-entry System § 6 F (2. 0 mm) guide catheter compatibility § 0. 014” (0. 36 mm) guidewire compatibility § Proximal Shaft OD 3. 2 F (1. 07 mm) § 0. 019” (0. 48 mm) distal tip crossing profile § 135 cm working length § 2. 5 mm x 10 mm flat self-orienting balloon with two ports § Designed to accurately target and re-enter IC-375101 -AA FEB 2016 the true lumen from the subintimal space Data on file at BSC

Wolverine Cutting Balloon NC Emerge Platform, Improved Flexibility, & Reduced Profiles Improved Deliverability & Reduced Profile Distal End Flexibility Tip Lesion Entry Flexibility Profile Recross/ Rewrap 5 F Compatibility Withdrawal into a Guide Improved Tip Flexibility and Visible Tip Improved Inner and Outer Flexibility Reduced Crossing Profile Improved Balloon Flexibility Reduced Tip Entry Profile

SYNERGY™ Everolimus-Eluting Platinum Chromium Stent with Abluminal Bioabsorbable Polymer § Abluminal bioabsorbable polymer (PLGA) with Everolimus applied to the abluminal surface only (“rollcoat”) § Synchronous drug release & polymer absorption with complete polymer absorption shortly after Everolimus PLGA § Thin strut (74 μm) Platinum Chromium stent* § Novel laser cut hypotube/stent delivery system Time (months) * For 2. 25 -2. 75 mm diameter Available stent lengths (mm) 8, 12, 16, 20, 24, 28, 32, 38 Available stent diameters (mm) 2. 25, 2. 50, 2. 75, 3. 00, 3. 50, 4. 00 ° After 120 days, polymer levels reach the limits of Boston Scientific’s detection methods. Boston Scientific data on file IC-375101 -AA FEB 2016 % Recovery drug elution is complete at 3 months°

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