Table S 2 A Ethnicity Sputum smear CXR

Table S 2 A Ethnicity Sputum smear CXR result Symptoms White Black ISC White ISC Black ISC ISC White Y Y Y (BAL) N N Y Y N N Y (BAL) Y Y N Density & cavity Density BHL Density & cavities Density Normal Cavitation Density & cavity Density Cough, sweats Cough, weight loss, sweats Cough, weight loss, sweats Cough, weight loss, sweats Weight loss, sweats Cough, sweats, weight loss Cough, sweats, weight loss 1 months 2 months 1 months 9 months 3 months 1 months 2 months 1 months 4 months 1 months 24 months N/A N/A 10 50 79 19 174 163 80 59 230 50 11 45 86 47 75 54 1. 01 1. 36 1. 22 1. 65 0. 34 1. 17 0. 48 1. 57 0. 6 2 1. 21 1. 6 0. 4 1. 5 1. 2 1. 7 6. 89 9. 5 4. 4 6. 89 6. 79 7. 99 3. 76 2. 52 10. 05 7. 4 5. 38 4. 93 0. 4 7. 8 7. 4 4. 1 2. 5 symptoms 4 mnths 77 1. 2 6 AVERAGE Symptom CRP Lymph Neut length mg/L x 109/L IGRA Other +ve +ve ND +ve +ve +ve Previous TB, smoker Diabetic Heavy smoker Alcohol excess Smoker Asthma Previous TB, smoker IGRA Other Table S 2 B Ethnicity Sputum smear CXR result Symptoms Black ISC - - - BHL, Density None Cough, fatigue, sweats None 1 years 2 months asymp 2 35 1 1. 3 0. 81 1. 92 2. 84 3. 57 2. 9 -ve -ve Black - BHL, Density Cough, dyspnoea, fatigue 2 years 17 1. 18 3. 43 -ve ISC Black ISC - - - BHL BHL 4 years 10 years asymp 1 2 1. 23 1. 26 1. 55 3. 78 3. 92 -ve -ve Black - BHL 8 months ND 1. 7 7 -ve White - - BHL BHL None Fatigue None Cough, dyspnoea, fatigue, weight loss, sweats None Fatigue None Psoriasis, 5 mg pred daily 6 months 2 months 5 years 2 months 8 1 12 2 1. 83 1. 37 2 1. 1 1. 92 3. 16 4. 6 6. 16 -ve -ve White - BHL None 3 years 9 1. 05 4. 53 -ve White White - - - BHL Density Fibrosis BHL, Density Fibrosis 9 years 13 years 10 years 2 years 4 years 10 years ND 4 3 ND 4 17 1. 52 2. 55 0. 68 1. 23 0. 43 0. 99 3. 19 3. 22 2. 15 5. 49 2. 73 7. 4 -ve ind -ve -ve White - BHL, Density 6 months 3 1. 6 3. 68 -ve White - BHL 5 years 4 1. 06 2. 86 -ve White - BHL, Density 4 years 1 0. 64 3. 29 -ve White Black White - - - Density BHL, Density None Fatigue Cough, dyspnoea, fatigue None Cough, dyspnoea, fatigue, weight loss None Cough None Autoimmune diseases Previous cancer Mild stroke Diabetes, Previous cancer Hypertension Diabetes, Hypertension Gout Glaucoma 9 years 6 years 4 years ND 4 ND 0. 65 0. 97 0. 61 4. 14 1. 53 2. 76 -ve -ve 1 symptom 4 yrs 6. 3 1. 3 3. 7 AVEARGE Symptom CRP Lymph Neut length mg/L x 109/L

Table S 2 C CURB 65 CRP Lymph Neut QFT score mg/L x 109/L (0 -5) Ethnicity +ve micro results CXR Symptoms White Mycoplasma Multilobar consolidation Cough, fevers White No Consolidation White Mycoplasma ME No Consolidation White No Consolidation ISC No Multilobar consolidation Cough, chest pain, dyspnoea, fevers, vomiting Cough, dyspnoea, fevers, nausea Mutlilobar Cough, haemoptysis, consolidation dyspnoea, fevers AVERAGE Fevers, malaise, nausea Cough, fevers, dyspnoea Cough, chest pain, dyspnoea, fevers Intravenous antibiotics before blood test (total doses) Other 0 321 0. 76 5. 43 3 383 1. 55 17. 36 Neg Previous TB 8 2 308 0. 94 19. 29 Neg Dementia 0 2 256 1. 63 14. 07 Neg HT, DM 2 0 88 1. 36 10. 34 Neg 1 259 0. 9 8. 49 Pos 0 34 21. 56 8. 2 Neg 0 505 2. 34 14. 83 Neg 270 3. 9 12. 3 3. 5 symptoms Neg 2 2 HT, DM 6 3 Smoker 5 3. 5 Table S 2 D Ethnicity Histology Lung Cancer Stage Symptoms Black White Squamous Adeno 4 3 b Weight loss, hemiparesis None White Large cell 3 a White Adeno 3 a 3 a White Adeno 3 b 3 a-b AVERAGE CRP Lymph Neut Other x 109/L 9 NA 0. 88 NA 7. 32 NA smoker Cough, weight loss, dyspnoea 42 1. 28 5. 34 ex-smoker Cough, weight loss, dyspnoea 133 1. 25 11. 67 smoker 160 1. 57 11. 03 ex-smoker NA 15. 7 0. 26 1. 93 8. 71 NR smoker Cough, haemoptysis, weight loss, sweats 146 1. 73 11. 27 ex-smoker 2. 6 symptoms 63 1. 3 9. 2 Cough, haemoptysis, weight loss, sweats None Cough, dyspnoea mg/L

Table S 2 E AVERAGE Sputum smear +ve CXR result No of Symptoms Symptom length (months) CRP mg/L Lymph x 109/L Neut x 109/L No of comorbidities TB Training 69% 75% densities, 50% cavities 2. 5 4 77 1. 2 6 1. 2 45% 78% densities, 44% cavities 2. 7 2. 5 77 1. 5 7. 0 1. 1 Yes No No TB Test & Validation p<0. 05 Table S 2 F AVERAGE Length of disease (months) No. of symptoms CXR stage 46. 3 0. 4 1. 8 0. 5 0. 0 29. 3 0. 4 1. 7 0. 7 No No Sarcoidosis Training Sarcoidosis Test & Validation p<0. 05 No of co- No. positive Lymph morbidities QFT x 109/L Neut x 109/L ACE IU/ml 1. 3 3. 7 95. 5 0. 0 1. 4 3. 8 84. 4 No No Table S 2 G AVERAGE Pneumonia Training Pneumonia Test p<0. 05 Oral +ve IV Antibiotics No with No. of Length CURB 6 CRP Lymph Neut Co. Antibiotics micro QFT before blood consolidation Symptoms (days) 5 mg/L x 109/L morbidities before test results test (doses) (days) 0. 3 1 3. 4 7. 3 0. 5 100 1. 4 6. 2 0. 2 1. 4 3. 0 3. 9 0. 3 1 3. 3 6. 1 0. 5 133 1. 4 7. 9 0. 0 1. 0 2. 9 3. 2 No No No Table S 2 H AVERAGE Lung Cancer Training Lung Cancer Test p<0. 05 Histology Lung Cancer Stage Symptoms CRP mg/L Lymph x 109/L Neut x 109/L Smoker/Ex-smoker 4 types 3 a-b 2. 3 84 1. 3 9. 2 0. 9 4 types 3 b 2. 8 47 1. 3 5. 7 0. 8 No Yes No No No