T cell Maturation Activation Differentation Hugh B Fackrell

T cell Maturation, Activation & Differentation Hugh B. Fackrell 10/31/2020 1

T cell Maturation, Activation & Differentation Assigned Reading l Content Outline l Performance Ojectives l – Key terms – Key Concepts l Short Answer Questions 10/31/2020 2

Assigned Reading Chapter: 12 pp 285 -310 l Janis Kuby’s Immunology 3 rd Ed l 10/31/2020 3

Content Outline l l T Cell Maturation T helper Cell Activation T Cell Differentiation Peripheral gamma delta T cells 10/31/2020 4

T Cell Maturation l l l Pre T cell receptor T cell development pathways Thymic Selection of T cells – positive selection – negative selection l T helper Cell Activation 10/31/2020 l l l TCR coupled signaling pathways Co-stimulatory signal Antagonists & Agonists Clonal Expansion Clonal Anergy Superantigens 5

T Cell Differentiation Effector & memory cells l Co-stimulatory differences l 10/31/2020 6

Peripherial T cells Distribution of cells l Ligands recognized l Functions l 10/31/2020 7

Performance Objectives 10/31/2020 8

Key Terms accessory molecules, antigen processing, associatve recogonition model, l independent recognition model, cell adhesion molecules, l subtractive hybrization l 10/31/2020 9

Key Concepts Outline antigen processing and presentation to TCR l Describe the molecular pathways for T cell activation l Describe positive and negative selection l Discuss the role of accessory molecules in T cell antigen recognition l 10/31/2020 10

Short Answer Questions 10/31/2020 11

T cell proliferation and differentiation lead to important immunological functions. What are they? l Briefly discuss the molecular events, collected called T-Cell activation, that lead to biologic function. l What is the importance of diacylglycerol and IP 3 in T-cell activation? l What transcription factors are involved in T cell activation? l 10/31/2020 12

DONE!!! 10/31/2020 13