Synthesis of Saxitoxin Fleming J J Du Bois

Synthesis of (+)-Saxitoxin Fleming, J. J. ; Du Bois, J. Am. Chem. Soc. 1981, 128, 3926 2021/3/1 Songnan Zhang 04/02/2013 1

Justin Du Bois Ø B. S. 1992, University of California at Berkeley Ø Ph. D. 1997, California Institute of Technology Ø NIH Postdoctoral Fellow, 1997 -1999 Massachusetts Institute of Technology Ø Tetrahedron Young Investigator Award, 2008 Ø John A. and Cynthia Fry Gunn University Fellows in Undergraduate Education, 2011 2021/3/1 2

Publish: 1) “Modular Synthesis of the Pentacylic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs, ” A. S. Devlin, J. Du Bois, Chem. Sci. , 4, 1059 -1063 (2013) 2) “A Designed Inhibitor of a CLC Antiporter Blocks Function Through a Unique Binding Mode, ” A. E. Howery, S. Elvington, S. J. Abraham, K. -H. Choi, S. Philips, C. M. Ryan, R. L. Sanford, S. Simpson. Dworschak, J. Almqvist, K. Tran, T. A. Chew, U. Zachariae, O. S. Andersen, J. Whitelegge, K. Matulef, J. Du Bois, M. Maduke, Chem. Biol. , 19, 1460 -1470 (2013) 3) “Capturing Fleeting Intermediates in a Catalytic C–H Amination Reaction Cycle, ” R. H. Perry, T. J. Cahill III, J. L. Roizen, J. Du Bois, R. Zare, Proc. Natl. Acad. Sci. USA, 109, 18295 -18299 (2012) 4) “Marked Difference in Saxitoxin and Tetrodotoxin Affinities for the Human Nociceptive Voltage-gated Sodium Channel (Na. V 1. 7), ” J. R. Walker, P. Novick, W. A. Parsons, M. Mc. Gregor, J. Zablocki, V. S. Pande, J. Du Bois, Proc. Natl. Acad. Sci. USA, 109, 18102 -18107 (2012) 5) “Fluorescent Saxitoxins for Live Cell Imaging of Voltage-gated Sodium Ion Channels Beyond the Optical Diffractin Limit, ” A. E. Ondrus, H. -l. D. Lee, S. Iwanaga, W. H. Parsons, B. M. Andresen, W. E. Moerner, J. Du Bois, Chem. Biol. , 19, 902 -912 (2012) 6) “Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds, ” M. E. Harvey, J. L. Roizen, Acc. Chem. Res. , 45, 911 -922 (2012) 7) “Catalytic C–H Oxidation by a Triazamacrocyclic Ruthenium Complex, ” E. Mc. Neill, J. Du Bois, Chem. Sci. , 3, 1810 -1813 (2012) 8) “A Diruthenium Catalyst for Selective, Intramolecular Allylic C–H Amination: Reaction Development and Mechanistic Insight Gained Through Experiment and Theory, ” M. E. Harvey, D. G. Musaev, J. Du Bois, J. Am. Chem. Soc. , 133, 17207 -17216 (2011) 2021/3/1 3

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