Synergistic effects of PRIMA1 Met APR246 and 5

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Synergistic effects of PRIMA-1 Met (APR-246) and 5 azacitidine in TP 53 -mutated myelodysplastic

Synergistic effects of PRIMA-1 Met (APR-246) and 5 azacitidine in TP 53 -mutated myelodysplastic syndromes and acute myeloid leukemia by Nabih Maslah, Norman Salomao, Louis Drevon, Emmanuelle Verger, Nicolas Partouche, Pierre Ly, Philippe Aubin, Nadia Naoui, Marie-Helene Schlageter, Cecile Bally, Elsa Miekoutima, Ramy Rahmé, Jacqueline Lehmann-Che, Lionel Ades, Pierre Fenaux, Bruno Cassinat, and Stephane Giraudier haematol Volume 105(6): 1539 -1551 June 1, 2020 © 2020 by Ferrata Storti Foundation

PRIMA-1 Met (APR-246, APR) is active on TP 53 -mutated acute myeloid leukemia (AML)

PRIMA-1 Met (APR-246, APR) is active on TP 53 -mutated acute myeloid leukemia (AML) cell lines and the combination of APR and azacitidine (AZA) is synergistic. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

The combination of PRIMA-1 Met (APR-246, APR) and azacitidine (AZA) promotes G 0/G 1

The combination of PRIMA-1 Met (APR-246, APR) and azacitidine (AZA) promotes G 0/G 1 arrest and apoptosis in various TP 53 -mutated acute myeloid leukemia (AML) cell lines. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

World Health Organization classification of cytogenetic and molecular characteristics of TP 53 mutated myelodysplastic

World Health Organization classification of cytogenetic and molecular characteristics of TP 53 mutated myelodysplastic syndromes/acute myeloid leukemia patients. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

Effects of PRIMA-1 Met (APR-246, APR) on primary cells from TP 53 -mutated myelodysplastic

Effects of PRIMA-1 Met (APR-246, APR) on primary cells from TP 53 -mutated myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML) patients and healthy donors. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

Effects of PRIMA-1 Met (APR-246, APR) on primary cells from TP 53 wild-type or

Effects of PRIMA-1 Met (APR-246, APR) on primary cells from TP 53 wild-type or mutated myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML) patients and healthy donors. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

In vivo efficacy of PRIMA-1 Met (APR-246, APR) and azacitidine (AZA) in a xenotransplantation

In vivo efficacy of PRIMA-1 Met (APR-246, APR) and azacitidine (AZA) in a xenotransplantation model. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

Changes in gene expression induced by treatment with PRIMA-1 Met (APR-246, APR) + azacitidine

Changes in gene expression induced by treatment with PRIMA-1 Met (APR-246, APR) + azacitidine (AZA). Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation

The antiproliferative effect of PRIMA-1 Met (APR-246, APR) + azacitidine (AZA) combination is related

The antiproliferative effect of PRIMA-1 Met (APR-246, APR) + azacitidine (AZA) combination is related to downregulation of the FLT 3 pathway. Nabih Maslah et al. Haematologica 2020; 105: 1539 -1551 © 2020 by Ferrata Storti Foundation