SYK inhibition thwarts the BAFF Bcell receptor crosstalk
SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia by Cody Paiva, Taylor A. Rowland, Bhargava Sreekantham, Claire Godbersen, Scott R. Best, Prabhjot Kaur, Marc M. Loriaux, Stephen E. F. Spurgeon, Olga V. Danilova, and Alexey V. Danilov haematol Volume 102(11): 1890 -1900 October 27, 2017 © 2017 by Ferrata Storti Foundation
B-cell activating factor (BAFF) promotes activation of pro-survival pathways in chronic lymphocytic leukemia (CLL) cells. Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
Expression of Mcl-1 and Bcl-x. L in chronic lymphocytic leukemia (CLL) lymph nodes. Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
B-cell activating factor (BAFF) activates BCR signaling in chronic lymphocytic leukemia (CLL) cells. Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
Inhibitors of BCR-associated kinases abrogate B-cell activating factor (BAFF)-mediated canonical NFκB activation in chronic lymphocytic leukemia (CLL). Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
SYK inhibition down-regulates Mcl-1 via STAT 3. Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
SYK interacts with TRAF 2/TRAF 3 in neoplastic B cells. Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
B-cell activating factor (BAFF)-BCR crosstalk in chronic lymphocytic leukemia (CLL) cells. Cody Paiva et al. Haematologica 2017; 102: 1890 -1900 © 2017 by Ferrata Storti Foundation
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