Surgical Planning Laboratory Brigham and Womens Hospital Boston

Surgical Planning Laboratory Brigham and Women’s Hospital Boston, Massachusetts USA a teaching affiliate of Harvard Medical School Overview Ron Kikinis, M. D.

Overview • Neurosurgery: – Alex Golby, Sandy Wells, CF Westin • Prostate: – Clare Tempany, Noby Hata, Steve Haker • Programmatic framework: – NAC Ron Kikinis, BIRN: Steve Pieper, IGT: Clare Tempany, Amigo: Randy Ellis © 2005 Surgical Planning Laboratory, ARR Slide 2

Schedule • • Neurosurgery Prostate NCRR portfolio Discussion © 2005 Surgical Planning Laboratory, ARR Slide 3

Neuroimage Analysis Center: NAC • Biotechnology resource center • Year 08 started on 8/1/2005 • Algorithm development and software tools for basic and clinical neuroscience • Cores: White Matter Architecture from DT-MRI, Clinical Computational Anatomy, Developmental Neuroinformatics, f. MRI Informatics, Visualization • Collaborations: Neurosurgery, Neurologic Imaging, Psychiatry © 2005 Surgical Planning Laboratory, ARR Slide 4

Matrix Organization Developmental Neuroanatomy T e c h n o l o g i e s f. MRI Informatics WM Architecture from DT-MRI BIRN Projects Clinical Computational Anatomy Visualization Registration Segmentation Visualization Modeling Variability Modeling Anatomy Modeling Biomechanics Filtering Systems Engineering © 2005 Surgical Planning Laboratory, ARR Slide 5

NAC: the Onion View © 2005 Surgical Planning Laboratory, ARR Slide 6

Interactions between NA-MIC, NAC, BIRN, IGT BIRN Focus: infrastructure, data distribution, computing e. g. Provides shared image databases and high speed network/computing for NA-MIC & NAC NA-MIC Data Focus: algorithms, engineering, general software tools e. g. Analysis of tensor and non-tensor diffusion data at three algorithm groups (UNC, Utah, MGH) , hosted on BIRN servers from four clinical sites (Dartmouth, Harvard, UCI, U of Toronto) National Level Science National Level Outreach Requirements, testing, tools Data repositories and access Advances in medical image computing NAC IGT Focus: specific applications, custom software tools e. g. Tensor analysis for pioneering diffusion technology from BWH Focus: guided therapies, ilinical integration e. g. Guiding neurosurgery to minimize white matter damage Local Level Science National Level Outreach © 2005 Surgical Planning Laboratory, ARR Slide 7

NAC / BIRN / NA-MIC / IGT Interactions • NAC – Neuroimaging Science that Leverages Unique Abilities of BWH and Close Collaborators – Widely Distributed and Disseminated • BIRN – National Data, Networking, and Computation Infrastructure – Adapt and Apply Advanced Tools to Biomedical Problems through GCRC and other Clinical Partners • NA-MIC – National Software Methodology and Novel Algorithms Drawing on Wide Range of Research Institutions – Establish Best Practices for Biomedical Application Software • IGT – Leading Computation, Imaging, and Therapeutic Research in Closely Coupled Laboratory – Leverage NAC, BIRN, and NA-MIC for Clinical Application © 2005 Surgical Planning Laboratory, ARR Slide 8