Suppositories Eighth week Second year Suppository Base 1

Suppositories Eighth week Second year

Suppository Base 1 -Fatty bases Melt at body temp. 2 -Water- soluble Dissolve or disperse in body fluids

1 -FATTY BASES COCOA BUTTER SUPPOSITORIE

1 -FATTY BASES COCOA BUTTER(THEOBROMA NATURAL OIL) MELTING POINT RANGE IS 3036 °C. MELT ON WARMING, AND RAPIDLY READILY SET ON COOLING. NONIRRITATING.

Disadvantages Α-FORM: MELTS AT 24°C Β-FORM: MELTS AT 28 -31°C. POLYMORPHISM Γ-FORM: MELTS AT 18°C. ADHERENCE TO THE MOLD NEEDS GOOD LUBRICATION RANCIDIT Y.

MOULDS

Lubricants Elegant suppositories free from surface depressions. Different in nature from the suppository mass. Cacao butter suppositories. Soft soap Glycerin Alcohol

Hydrophilic bases (e. g. glycerol-gelatin base). Oily lubricant (Liquid paraffin) Notes ü Melt cacao butter it in a dish on a water bath until two thirds melt. ( overheating produces unstable forms with low melting point) ü Pour the melted mass into the well lubricated mould gradually (Let the mass to overflow)

DISPLACEMENT VALUES (D. V. ) § IT IS AMOUNT OF MEDICAMENTS THAT DISPLACES ONE GRAM OF THE BASE. § THE DENSITY OF MEDICAMENTS AFFECTS THE AMOUNT OF THE BASE REQUIRED FOR EACH SUPPOSITORY.

PLAI 0. 1 B N 0. 9 B 10% DRUG A B A – 0. 9 B

R/ DRUG X 50 MG COCOA BUTTER Q. S. MAKE SUPPOSITORIES, SEND THREE SIG: M. D. U.

PROCEDURES 1 - PLAIN SUPPOSITORY PORCELAI N DISH WATER BATH FLAME 1) 10 G COCOA BUTTER MELT 2) REMOVE FROM BATH THEN STIR 3) LUBRICATE THE MOLD 4) FILL THE MOLD (OVER FILLING) 5) PUT IN REFRIGERATOR (5 MIN) 6) REMOVE EXCESS OVER FILLING THEN WEIGH BEST SUPPOSITORIES

PROCEDURES 2 - MEDICATED SUPPOSITORY 1 - IN THE SAME MOLD REPEAT THE PREVIOUS STEPS USING 1 G DRUG X AND 9 GRAM COCOA BUTTER. 2 - CALCULATE THE D. V. THEN Q. S. AS FOLLOWS

CALCULATIONS 1 - WEIGHT OF ONE PLAIN (NON MEDICATED) SUPPOSITORY = A 2 - WEIGHT OF ONE MEDICATED SUPPOSITORY CONTAINING 10% MEDICAMENTS = B 3 - AMOUNT OF BASE IN ONE MEDICATED SUPPOSITORY = 0. 9 B 4 - AMOUNT OF MEDICAMENT IN ONE MEDICATED SUPPOSITORY = 0. 1 B

5 - THE AMOUNT OF BASE DISPLACED = A – 0. 9 B 6 - DISPLACEMENT VALUE = 0. 1 B / AMOUNT OF BASE DISPLACED 7 - BASE DISPLACED IN R/ = AMOUNT OF MEDICAMENT IN R/ (50 MG) / D. V. 8 - Q. S. = A – BASE DISPLACED IN R/

DISPLACEMENT VALUES CALCULATION D. V = AMOUNT OF THE DRUG BASE DISPLACED

BASE DISPLACED IN R/ IF D. V = 0. 2 GM DRUG 0. 05 GM DRUG 1 GM BASE XX XX = 0. 05 *1 / 0. 2 SO, DRUG AMOUNT IN BASE DISPLACED IN R/ = R/ D. V • Q. S. (1 SUPP. ) = A – BASE DISPLACED IN R/ A =2 G WEIGHT OF ONE PLAIN SUPP.

LABEL • NAME OF PREPARATION: COCOA BUTTER SUPPOSITORIES • DIRECTIONS: TO BE USED AS DIRECTED • COLOR : RED • USE: EXTERNAL