Supplementary Training Modules on GMP Air Handling Systems

Supplementary Training Modules on GMP Air Handling Systems Heating Ventilation and Air Conditioning (HVAC) Part 2: Components Module 3, Part 2: Components Slide 1 of 20 WHO - EDM

Air Handling Systems Purpose of an air handling system Air Handling System Supply Air Module 3, Part 2: Components Production Room With Defined Requirements Slide 2 of 20 Outlet Air WHO - EDM

Air Handling Systems Objectives In the following slides, we will study the components of air handling systems in order to: 1. become familiar with the components 2. know their functions 3. become aware of possible problems Module 3, Part 2: Components Slide 3 of 20 WHO - EDM

Air Handling Systems Main subsystems Exhaust air treatment Fresh air treatment (make-up air) + Terminal air treatment at production room level Production Room Central air handling unit Module 3, Part 2: Components Slide 4 of 20 WHO - EDM

Air Handling Systems Overview components Exhaust Air Grille Silencer Weather louvre Flow rate controller Fan Control damper Filter Heater + Humidifier Prefilter Heating coil Cooling coil with droplet separator Module 3, Part 2: Components Terminal filter Secondary Filter Production Room Re-circulated air Slide 5 of 20 WHO - EDM

Air Handling Systems Components (1) l Weather louvre l Silencer l Flow rate controller l Control damper Module 3, Part 2: Components To prevent insects, leaves, dirt and rain from entering To reduce noise caused by air circulation Automated adjustment of volume of air (night and day, pressure control) Fixed adjustment of volume of air Slide 6 of 20 WHO - EDM

Air Handling Systems Components (2) l Heating unit To heat the air to the proper temperature l Cooling unit /dehumidifier To cool the air to the required temperature or to remove moisture from the air l Humidifier To bring the air to the proper humidity, if too low l Filters To eliminate particles of pre-determined dimensions and/or micro-organisms l Ducts To transport the air Module 3, Part 2: Components Slide 7 of 20 WHO - EDM

Air Handling Systems Problems with components l Flow rate controller Blocked l Control damper Poorly adjusted, bad pressure differential system l Humidifier Bad water/steam quality/poor drainage l Cooling battery No elimination of condensed water/poor drainage l Filters Incorrect retention rate/damaged/badly installed l Ducts Inappropriate material/internal insulator leaking Module 3, Part 2: Components Slide 8 of 20 WHO - EDM

Air Handling Systems Air types Fresh air (make-up air) Supply air Exhaust air + Production Room Return air (re-circulated) Module 3, Part 2: Components Slide 9 of 20 WHO - EDM

Air Handling Systems Comparing International Cleanroom Classifications Module 3, Part 2: Components Slide 10 of 20 WHO - EDM

Air Handling Systems Filter classes Dust filters Standard Aerosol Coarse Fine HEPA Dp > 10 µ m > Dp > 1 µ m G 1 - G 4 F 5 - F 9 Dp < 1 µ m H 11 - 13 EN 779 Standard Module 3, Part 2: Components ULPA U 14 - 17 EN 1822 Standard Slide 11 of 20 WHO - EDM

Air Handling Systems Module 3, Part 2: Components Slide 12 of 20 WHO - EDM

Air Handling Systems HEPA or tertiaary filter Primary panel filter Secondary filter Module 3, Part 2: Components Slide 13 of 20 WHO - EDM

Air Handling Systems Humidifier Silencer Heating and cooling units Module 3, Part 2: Components Slide 14 of 20 WHO - EDM

Air Handling Systems Control damper for air flow Humid room air Adsorber wheel Regeneration air Dry air AHU with fan Variable Speed Controller Humid room air Filter Pressure Gauges Air heater De-humidification Module 3, Part 2: Components Air handling unit Slide 15 of 20 WHO - EDM

Air Handling Systems 1 2 3 4 Filter Swirl Tightening frame Register outlet Screw fixation for register Module 3, Part 2: Components Type air diffusors with terminal filters Slide 16 of 20 WHO - EDM

Air Handling Systems High induction office type diffusor (avoid) Module 3, Part 2: Components Low induction swirl diffusor (preferred) Slide 17 of 20 WHO - EDM

Air Handling Systems Regulation of room pressure – pressure differentials concept Room pressure gauges Room pressure indication panel Annex 1, 17. 26 Module 3, Part 2: Components Slide 18 of 20 WHO - EDM

Air Handling Systems Pressure cascade injectables Protection from micro-organisms and particles Annex 1, 17. 24, 17. 25 Module 3, Part 2: Components Slide 19 of 20 WHO - EDM

Air Handling Systems Pressure cascade solids Protection from cross-contamination Module 3, Part 2: Components Slide 20 of 20 WHO - EDM