Supplementary Table 1 Genetic status and AUY 922

Supplementary Table 1 Genetic status and AUY 922 sensitivity of 10 human T-ALL cell lines tested in the study Cell line Major Oncogene chromosomal group rearrangement NOTCH 1 HD PEST domain FBXW 7 PTEN TP 53 IC 50 values for AUY 922 TYK 2 Other genetic genes status 72 h 96 h DND 41 - - Mut Ins WT WT Mut - WT < 10. 0 SUP-T 13 TAL 1 MLL-ENL WT WT WT - - - WT < 10. 0 KOPT-K 1 - LMO 2 -TCRG Mut Del WT WT Mut - WT 13. 3 < 10. 0 HPB-ALL TLX 3 - Mut Ins WT WT - WT 15. 8 < 10. 0 MOLT-4 TAL 1 - Mut Del WT Null Mut 17. 5 < 10. 0 TALL-1 - - WT WT WT - Mut - WT 17. 8 < 10. 0 MOLT-16 TAL 1 MYC-TCRA, SIL-TAL 1 WT WT WT Null Mut - Mut 19. 8 < 10. 0 LOUCY ETP - WT WT WT Null Mut - WT 21. 1 < 10. 0 RPMI-8402 TAL 1 LMO 1 -TCRD, SIL-TAL 1 Ins WT Mut Ins, Mut - Mut 24. 0 < 10. 0 JURKAT TAL 1 WT WT Mut Null Mut CREBBP Mut WT 30. 6 17. 0 - JAK 1 E 966 V NRAS G 12 C References; Maser et al (2007) (36); O'Neil et al (2007) (37); Palomero et al (2007) (38); Weng et al (2004) (39); Shepherd et al (2013) (40); Sanda et al (2013) (6); Mansour et al (2013) (41) IC 50, 50% inhibitory concentration; WT, wild-type; Null, no detectable expression; Mut, mutation; Del, deletion; Ins, insertion