Supplementary data 2 Non regulated Down regulated Non

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Supplementary data 2 Non regulated Down regulated Non spotted Up regulated

Supplementary data 2 Non regulated Down regulated Non spotted Up regulated

262, 500 265, 000 CBU_0296 267, 500 270, 000 CBU_0299 M F CBU_0298 L

262, 500 265, 000 CBU_0296 267, 500 270, 000 CBU_0299 M F CBU_0298 L S CBU_0302 F CBU_0301 K CBU_0304 TK CBU_0303 J LK CBU_0305 CS 60 CS 30 CBU_0300 HS 30 CBU_0297 HS 60 CBU_0295 J

422, 500 425, 000 427, 500 430, 000 432, 500 CBU_0489 J M CBU_0486

422, 500 425, 000 427, 500 430, 000 432, 500 CBU_0489 J M CBU_0486 E ET CBU_0482 E CBU_0484 CBU_0487 CBU_0491 J J CBU_0488 CBU_0493 I I CBU_0492 CS 60 CS 30 E CBU_0485 HS 30 CBU_0483 CBU_0490 HS 60 CBU_0481 L

545, 500 546, 250 548, 750 547, 500 550, 000 H CBU_0597 CBU_0601 CBU_0598

545, 500 546, 250 548, 750 547, 500 550, 000 H CBU_0597 CBU_0601 CBU_0598 CBU_0602 CBU_0603 CBU_600 P CS 60 CBU_0599

555, 000 557, 500 560, 000 562, 500 CBU_0609 I CBU_0617 CBU_0610 CBU_0611 M

555, 000 557, 500 560, 000 562, 500 CBU_0609 I CBU_0617 CBU_0610 CBU_0611 M CBU_0613 M CBU_0612 M CBU_0615 I CBU_0614 M R CBU_0616 CS 30 I

647, 500 650, 000 652, 500 655, 000 CBU_0703 R CBU_0699 CBU_0702 CBU_0700 GM

647, 500 650, 000 652, 500 655, 000 CBU_0703 R CBU_0699 CBU_0702 CBU_0700 GM CBU_0704 CBU_0705 CBU_0707 P CBU_0706 CS 30 CBU_0701 CS 30 P GM

HS 60

HS 60

CBU_0833 R CBU_0832 V 790, 000 CBU_0837 CBU_0835 CBU_0839 H R M CBU_0834 CBU_0836

CBU_0833 R CBU_0832 V 790, 000 CBU_0837 CBU_0835 CBU_0839 H R M CBU_0834 CBU_0836 CBU_0838 M CS 30 787, 500 HS 30 785, 000

892, 500 895, 000 CBU_0944 CBU_0942 CBU_0945 897, 500 CBU_0946 900, 000 CBU_0949 CBU_0947

892, 500 895, 000 CBU_0944 CBU_0942 CBU_0945 897, 500 CBU_0946 900, 000 CBU_0949 CBU_0947 902, 500 CBU_0951 CBU_0950 CBU_0952 P CBU_0948 CS 30 CBU_0943

1, 145, 000 1, 147, 500 1, 150, 000 CBU_1206 J CBU_1205 CBU_1201 CBU_1202

1, 145, 000 1, 147, 500 1, 150, 000 CBU_1206 J CBU_1205 CBU_1201 CBU_1202 CBU_1207 CBU_1204 G CS 30 CBU_1208 HS 30 CBU_1203 C HS 60 E

1, 217, 500 1, 220, 000 CBU_1268 CBU_1270 I CBU_1263 H CBU_1265 H CBU_1272

1, 217, 500 1, 220, 000 CBU_1268 CBU_1270 I CBU_1263 H CBU_1265 H CBU_1272 CBU_1274 MR CBU_1270 a CBU_1275 CBU_1269 a S G CBU_1267 CBU_1273 CS 60 S CBU_1267 a 1, 225, 000 L CBU_1269 CBU_1264 CBU_1262 CBU_1266 1, 22é, 500 HS 60 1, 215, 000 1, 212, 500

1, 235, 000 1, 2237, 500 1, 240, 000 1, 242, 500 CBU_1282 EF

1, 235, 000 1, 2237, 500 1, 240, 000 1, 242, 500 CBU_1282 EF 1, 245, 000 CBU_1289 EF O CBU_1287 CBU_1281 CBU_1284 CBU_1286 R R CBU_1285 O CBU_1290 CBU_1291 CBU_1288 HS 30 1, 232, 500

HS 60 CS 30

HS 60 CS 30

CS 30

CS 30

CS 30

CS 30

1, 885, 000 1, 887, 500 CBU_1969 CBU_1976 MJ E CBU_1971 CBU_1973 R CBU_1979

1, 885, 000 1, 887, 500 CBU_1969 CBU_1976 MJ E CBU_1971 CBU_1973 R CBU_1979 CBU_1977 CBU_1974 R CBU_1975 CBU_1978 M CBU_1981 O H CBU_1980 CS 60 T 1, 892, 500 HS 30 CBU_1972 1, 890, 000

SUPPLEMENTARY MATERIAL Krysov et al Supplementary methods SupplementarySUPPLEMENTARY MATERIAL Krysov et al Supplementary methods Supplementary
Supplementary table 1 Supplementary table 2 Supplementary tableSupplementary table 1 Supplementary table 2 Supplementary table
SRM Supplementary Information SRMSHO304 SRM Supplementary Information SupplementarySRM Supplementary Information SRMSHO304 SRM Supplementary Information Supplementary
Ethylene Oxide Regulated areas v Regulated areas mustEthylene Oxide Regulated areas v Regulated areas must
Unit 6 Regulated power supply 6 1 RegulatedUnit 6 Regulated power supply 6 1 Regulated
Down Syndrome resources Down Syndrome Helpline National DownDown Syndrome resources Down Syndrome Helpline National Down
DOWN TO GOD DOWN TO US DOWN TODOWN TO GOD DOWN TO US DOWN TO
Supplementary figures Supplementary Fig 1 Effect of GSupplementary figures Supplementary Fig 1 Effect of G
SUPPLEMENTARY FIGURE S 1 LEGEND Supplementary Fig SSUPPLEMENTARY FIGURE S 1 LEGEND Supplementary Fig S
SUPPLEMENTARY FIGURE S 2 LEGEND Supplementary Fig SSUPPLEMENTARY FIGURE S 2 LEGEND Supplementary Fig S
Supplementary Figures Tables and information Supplementary Figures 1Supplementary Figures Tables and information Supplementary Figures 1
Supplementary Figures Supplementary Figure 1 AD Principal coordinateSupplementary Figures Supplementary Figure 1 AD Principal coordinate
Supplementary Fig 1 Supplementary Figure 1 Distributions ofSupplementary Fig 1 Supplementary Figure 1 Distributions of
Supplementary Figure 1 A B C Supplementary FigureSupplementary Figure 1 A B C Supplementary Figure
Supplementary figures Supplementary Fig 1 Effect of GSupplementary figures Supplementary Fig 1 Effect of G