Supplemental Figure 1 Genes induced by low ferritin

Supplemental Figure 1. Genes induced by low ferritin also correlated strongly with serum EPO concentration in VHLR 200 W homozygotes. P-values in right panels denote Spearman’s rank test for correlation between gene expression level and log (EPO) in VHLR 200 W homozygotes.

Supplemental Figure 2 The magnitude of ferritin effect on gene expression was strong for VHLR 200 W induced genes whose expression was enhanced by iron deficiency in VHLR 200 W homozygotes. Twelve example genes were shown for CSDA (A), SLC 4 A 1 (B), SELENBP 1 (C), AHSP (D), HBD/HBB (E), BPGM (F), FECH (G), EPB 42 (H), DCAF 12 (I), SLC 25 A 39 (J), FAM 46 C (K), and SNCA (L). P-values in right panels denote Spearman’s rank test for correlation between gene expression level and log (ferritin) in VHLR 200 W homozygotes.

Supplemental Figure 3. The magnitude of ferritin effect on gene expression was generally mild for VHLR 200 W induced genes whose expression was suppressed by iron deficiency in VHLR 200 W homozygotes. Twelve example genes were shown for CD 300 E (A), CD 151 (B), GRN (C), SECTM 1 (D), MEFV (E), ATP 6 V 0 D 1 (F), P 2 RX 1 (G), PLD 3 (H), MPDU 1 (I), SLC 16 A 3 (J), MTHFD 2 (K) and ARAP 1 (L). P-values in right panels denote Spearman’s rank test for correlation between gene expression level and log (ferritin) in VHLR 200 W homozygotes.