Supplemental Digital Content 3 Figure 2 Murata et

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Supplemental Digital Content 3, Figure 2 Murata et al. Acute lethal crush-injured rats can

Supplemental Digital Content 3, Figure 2 Murata et al. Acute lethal crush-injured rats can be successfully rescued by a single injection of high-dose dexamethasone through a pathway involving PI 3 KAkt-e. NOS signaling Isamu Murata, Ph. D, Kazuya Ooi, Ph. D, Shingo Shoji, MS, Yohei Motohashi, BS, Miwa Kan, BS, Kazuo Ohtake, Ph. D, Soichiro Kimura, Ph. D, Hideo Ueda, Ph. D, Genya Nakano, MS, Kunihiro Sonoda, MS, Yutaka Inoue, Ph. D, Hiroyuki Uchida, Ph. D, Ikuo Kanamoto, Ph. D, Yasunori Morimoto Ph. D, and Jun Kobayashi, MD, Ph. D SDC Figure 2: Effects of the conventional therapies on the survival rate of CS rat. The survival rates among the four groups treated with or without conventional therapies from 0 to 48 h after reperfusion. Open circle: sham (n=10), closed circle: CS control (n=29), open square: CS+saline (n=10), closed square: CS+BICARBONR groups (n=10). Aggressive saline resuscitation showed a high survival rate (90%) until 6 hours after reperfusion, although it ultimately ended in failure 48 hours after reperfusion with a final mortality rate (30%) similar to the CS control group. CS+BICARBONR group showed a higher survival rate (60%) at 48 hour experimental period, however it does not appear nearly so good as the highdose DEX-treated group. #: p<0. 01 vs. CS control group. Survival curves were calculated by the Kaplan-Meier method and compared by a log-rank test.

SDC 3, Figure 2 Survival rates (%) 100 ○ sham ● CS control □

SDC 3, Figure 2 Survival rates (%) 100 ○ sham ● CS control □ CS+saline ■ CS+BICARBON® 75 ## 50 25 0 0 10 20 30 Time after reperfusion (h) 40 48