Supplement Supplement table 1 PreCOV AMI 96 51

Supplement

Supplement table 1 Pre-COV AMI 96 51 death 5 9 % death 5. 2% 17. 7% - 47% +12. 5% Supplement table 1: Hospitalization and case fatality rate for acute myocardial infarction during Covid-19 pandemic: Reduced number of admissions for acute myocardial infarction (AMI) during early-Covid-19 (e-COV=March 1 st to April 30 th) pandemic compared to the pre-Covid-19 time (pre-COV=January 1 st to February 29 th). Increased mortality rate in Covid-19 outbreak compared to pre-Covid-19 time: Absolute number of admissions for AMI during e-COV (N= 51) and pre-COV (N=96). Data are absolute values or percentage. Statistical significance was reached with a p<0. 05.

Supplement table 2 01/2019 02/2019 03/2019 04/2019 AMI 51 50 54 53 death 4 4 4 8% 7. 4% % death 7. 8% 01/2020 02/2020 03/2020 04/2020 AMI 48 48 28 23 3 death 3 2 5 4 5. 6% % death 6. 3% 4. 2% 17. 9% 17. 4% Supplement table 2: Admission for acute myocardial infarction and mortality between January and April 2020 compared to the previous year 2019: There were no differences in hospitalizations for AMI in January and February 2020 and 2019, while in March and April 2020 admissions for AMI halved compared to 2019. Absolute number of admissions. Mortality was unchanged in January and February 2020 and 2019, however in March mortality rate increased by 10. 5% and in April by 11. 8% in 2020 (Covid-19 outbreak) compared to 2019. Case fatality rate among patients admitted for AMI in percentage.

Supplement table 3 Cardiac outcome Pre-COV N=96 e-COV N=51 p-value CK-MB max (U/l) 101± 150 158± 180 0. 05 CK max (U/l) 880± 1343 1500± 2297 0. 04 46± 16 39± 16 0. 01 NTpro. BNP (ng/l) 5347± 8670 (N=81) 9935± 12922 (N=32) 0. 03 Days in hospital 10. 3± 11. 2 9. 4± 8. 7 0. 91 LVEF (%) Supplement table 3: Marker for cardiac injury, damage and cardiac outcome: High sensitive troponin (Troponin hs, ng/l) and creatine kinase (CK, U/l) at first medical contact during Covid-19 pandemic as marker for myocardial injury. Myocardial subunit of creatine kinase (CK-MB, U/l) and maximum measured creatine kinase (CKmax, U/l) as marker for total myocardial damage after AMI during Covid-19 outbreak. Left ventricular ejection fraction (LVEF, %). NTpro. BNP (ng/l) as biomarker for heart failure. Data are mean±SD. Statistical significance was reached with a p<0. 05.