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Previously diagnosed DM Newly diagnosed DM Fasting Glu ≥ 126 Random Glu ≥ 200 Hb. A 1 c ≥ 6. 5% Stress hyperglycemia Fasting Glu ≥ 126 Random Glu ≥ 200 Hb. A 1 c < 6. 5%

Immune response - ↑ TNF - ↑ IL-1 - ↑ IL-6 Preexisting abnormal glucose metabolism Stress reaction - Stimulation of HPA axis - ↑ Catecholamines - ↑Cortisol - ↑Glucagon Insulin resistance Glycogenolysis Gluconeogenesis Proteolysis Lipolysis

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