Steve Holmes Ph D Director Therapeutic Targets Kymab

Steve Holmes, Ph. D Director, Therapeutic Targets Kymab Limited

I am in the Biotechnology industry DNA A code Organised into genes >30, 000 in each of us Each gene Can be translated Into a specific protein Proteins are large and complex and carry out the body’s functions Most biological medicines are PROTEINS 1

Biologics : Some of the Molecules used in Medicine Biologics. Some of the Molecules MW ca. 18, 500 -Interferon Aspirin MW 180 Insulin MW ca. 6, 000 Ig. G Monoclonal Antibody MW ca. 160, 000

Pharmaceutical Product Sales Top 10 - Sales $Billion 70 Total Sales $Billion 600 60 50 400 40 30 Biologic Drugs Conventional Drugs 200 20 10 100 0 0 2008 2014 2000 2008 2014 • By 2014 Biologics are expected to account for 75% ($50 Bn) of the revenues from the top 10 best selling drugs • Five of the Top 10 are predicted to be monoclonal antibodies

Mechanism of Action of Monoclonal Antibodies Unique binding function Effector function Monoclonal Antibody

Clinical use of Monoclonal Antibodies Rheumatoid Arthritis – Disease Reversal Clinically Approved anti-TNF Monoclonal Antibodies for RA Remicade Humira

A day in the life of Steve Holmes ►Research ideas for monoclonal antibody therapy for Amyotrophic lateral sclerosis IP, literature and competition searches Review list of experts in field ►Prepare for meeting with Contract Manufacturing Organisation ►Attend antibody research group meeting ►Attend management meeting ►Telecon with Wellcome Trust ►Prepare project plan for new monoclonal

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development Early clinical Late clinical trials Approval What is my job in the cycle? What skills are required to do my job? • Ideas • Immunology, biochemistry, molecular biology • Research • Antibody generation, antibody engineering, cell line development and manufacturing • Development • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development Early clinical Late clinical trials Approval What skills are required to do my job? How did I gain the skills? • Immunology, biochemistry, molecular biology Post-Doc (3 years) Assistant Professor (4 years) On job training • Antibody generation, engineering, cell line development and manufacturing • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development What skills are required to do my job? Early clinical Late clinical trials Approval How did I gain the skills? • Immunology, biochemistry, molecular biology • Antibody generation, engineering, cell line development and manufacturing • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record Academia Biotech. and Pharma. industry

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development What skills are required to do my job? Early clinical Late clinical trials Approval How did I gain the skills? • Immunology, biochemistry, molecular biology • Antibody generation, engineering, cell line development and manufacturing • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record Academia Biotech. and Pharma. industry 30+ Patents 60+ Publications

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development What skills are required to do my job? Early clinical Late clinical trials Approval How did I gain the skills? • Immunology, biochemistry, molecular biology • Antibody generation, engineering, cell line development and manufacturing • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record Pharma and Biotech industry

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development What skills are required to do my job? Early clinical Late clinical trials Approval How did I gain the skills? • Immunology, biochemistry, molecular biology • Antibody generation, engineering, cell line development and manufacturing • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record Biotech industry 30+ Patents, 60+ publications

Kymab: Therapeutic monoclonal antibody company Life cycle: idea to clinic Ideas Research ~8 years Development Early clinical Late clinical trials 4 m. Abs What skills are required to do my job? Approval Bosatria How did I gain the skills? • Immunology, biochemistry, molecular biology • Antibody generation, engineering, cell line development and manufacturing • Disease biology expertise • Clinical trials • IP, Fund raising, Bus. Dev. • Years of experience • Track record 30+ years Monoclonal antibodies in clinical trials Domantis – sold to GSK for £ 230 M

Biotechnology Industry Salary, Career path and career progression/promotion opportunities BSc Ph. D 0 – 4 years experience ~£ 18 K - £ 35 K ~£ 20 K - £ 50 K Career Path Science Career Opportunities Research Associate Marketing/Sales Scientist Patent attorney Senior Scientist Business Dev. /CBO Director CEO CSO Consultant Found own company