Stem cells and materials technologies Group 16 Biomaterials

Stem cells and materials technologies Group 16 - Biomaterials and waste treatment Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. th July E-mail: rasousa@stemmatters. com Zona Industrial da Gandra | S. Cláudio do Barco Ciência 2009, 29 -30 2009, Lisbon Website: www. stemmatters. com APARTADO 4152 | 4805 CALDAS TAIPAS

Strategic Intent To target clinical needs through the integration of advanced adult stem cell biology and novel biomaterials into innovative therapeutic products for tissue regeneration Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

History Academic spin-off of the 3 B’s Research Group Installed since September 2008 at the European Institute of Excellence for Tissue Engineering and Regenerative Medicine Research, Guimarães, Portugal. Equipped with a future c. GMP compliant facility for the processing of human tissue and cells (2003/94/EC Directive): Created in November, 2007 300 m 2 of clean room (classes B, C and D); 250 m 2 of R&D and QC laboratories. 1 st funding round estimated to be finished by Sept, 2009 Start of operations estimated by Oct, 2009 Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Team CSO: Rui L. Reis, CEng. , MSc. , Ph. D. (n. 1968) – Founder, President and Chief Scientific Officer: is an Associated Professor at the Department of Polymer Engineering and Director 3 B’s Research Group. Editor in Chief of the Journal of Tissue Engineering and Regenerative Medicine, John Wiley and Sons Inc. He is author or co-author of more than 900 scientific publications. CEO: Rui A. Sousa, CEng. , MBA. , Ph. D. (n. 1974) – Chief Executive Officer: is a senior researcher at the 3 B’s Research Group. Possesses business experience in several industrial and consultancy domains. He is author or coauthor of more than 90 scientific publications and communications. Dulce Costa Luísa Pereira João Oliveira Adrian Popa Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Social Context The WHO estimates that more than 600 million people are aged above 60, being estimated that this number reaches the 2 billion by 2050. Growing impact of degenerative or traumatic conditions due to demographic evolution, more dynamic lifestyles, and increased physical activities. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Overall Market Regenerative Medicine 1 3 5 4 Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS Adaptado de Julian H S George et al http: //www. centropede. com/UKSB 2006/e. Poster 2 E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Use of stem cells from adipose tissue More than 1. 6 billion people are overweight, of which 400 million are considered obese, with treatment costs between 2 and 8% of total health costs. Steep increase in aesthetical surgical procedures, being Europe responsible for about one third of this global market. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Business Portfolio Stemmatters Therapeutics Stemmatters Life Banking Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Stemmatters Biomedical Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Stemmatters Therapeutics Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Current Markets The Market for Cartilage Regeneration Prevalence of articular cartilage related lesions in Europe Nearly 250. 000 traumatic incidents occur; About 7 million cases of treatable arthrosis occur each year. High market potential for cartilage regeneration Among the biggest markets for connective tissues, being estimated between 1 to 5 billion €/year in Europe alone. Very high penetration of traditional treatment approaches Arthroscopic lavage and debridement, microfracture and mosaicplasty rule the treatment of cartilage lesions. Cell based therapies with reasonable track record in this area ACT and MACI procedures are considered market references. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Products Under Development Types of products currently under development: ATMPs (Advanced Therapy Medicinal Products) G 01 AT 110 C | pre-clinical | RECART Hydrogel/Adipose derived adult stem cells G 01 AT 300 A | research | Hydrogel/Vascular stromal fraction derived cells MDs (Medical Devices) G 01 MD 210 B | research | Injectable filler for soft tissue applications G 01 MD 250 B | research | Injectable filler system for maxillofacial applications Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells Combined advanced therapy medicinal product (1394/2007 Regulation, CBMP EMEA guideline) Polysaccharide hydrogel as an active implantable device Exopolysaccharide produced by microbial fermentation: • Straight chain of repeating glucose, rhamnose and glucuronic acid units; • Potential injectable system for minimally invasive surgeries; • Processing under physiogical conditions without any reagents; • Used in vivo for human ophthalmic applications and oral veterinary drug delivery. Adipose derived adult stem cells Isolated from harvested adipose tissue: • Dedicated or non-dedicated harvest procedure; • Subpopulation isolated from the stromal vascular fraction; • Good cell yield avoids previous cell expansion. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells J. T. Oliveira et al, Patent Application Novel hydrogel system for TE applications Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells Good performance upon subcutaneous implantation 1 WEEK 2 WEEKS 3 WEEKS No clear macroscopic change after 3 weeks of implantation. Extremely good integration with the surrounding tissues with a residual and thin fibrotic capsule. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells Human chondrocytes form hyaline-like cartilage in vitro 8 WEEKS • Col 1 was not detected after 8 weeks Col 2 increased ≈ 400 fold from 2 -8 weeks Aggrecan increased ≈ 35 fold from 2 -8 weeks Sox 9 decreased close to zero from 2 -8 weeks house-keeping gene: GAPDH Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells ADIPOSE TISSUE FROM THE INTRASCAPULAR REGION CHONDROGENIC PRE ≠ MEDIUM BASIC MEDIUM WITH TGF-Β 1 + BMP-2 WITH NO PRE ≠ Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. ARTICULAR CARTILAGE FROM THE JOINTS PROLIFERATION INDUCING MEDIUM WITH FGF-2 Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells Rabbit articular cartilage Implantation site Articular cartilage full-thickness defect Subchondral drill (4 mm x 2 -3 mm thickness) (Ø 1 mm) Study groups A. Gellan + adipose tissue derived cells with pre differentiation period (ASC + GF*) + B. Gellan + adipose tissue derived cells with no pre differentiation period (ASC) + C. Gellan + articular chondrocytes (AC) + D. Gellan alone (GELLAN) *TGF-Β 1 + BMP-2 Autologous approach E. Empty defect (EMPTY) Total implantation time: 8 weeks Characterization [Cells]=10 x 106 cells/ml Macroscopic observation Histology (H&E for cell morphology and tissue formation and alcian blue for cartilage ECM formation) Histological scoring (Pineda score) Real-time PCR analysis (Sox 9, Collagen type II, and Aggrecan) Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS J. T. Oliveira et al, Patent Application E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells 0 weeks 4 weeks 8 weeks Combination of hydrogel with ASCs is able to regenerate focal cartilage lesions J. T. Oliveira et al, Patent Application Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Patent Application/Priority date: 01. 2008 Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline Stemmatters Therapeutics | RECART Hydrogel/Adipose derived adult stem cells Advantages of the cartilage repair strategy include: Potential therapeutic performance Minimally invasive system to be administered arthroscopically Avoids the need for a cartilage biopsy Shorter time to therapy (TTT) Competitive cost as compared to traditional ACT and MACI procedures Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Competition Tissue Engineering Products Cartilage application Arthro Kinetics, Bio. Tissue Technologies, Cellgenix, co. don, Curasan, Educell, Fidia Advanced Biopolymers, Geistlich Surgery, Genzyme Biosurgery, Histogenics, Interface Biotech, Karocell Tissue Engineering, Orthogen, TIGenix, TETEC, Verigen Transplantation Service International Cartilage: application Stemmatters (Autologous) Bone application Aastrom Biosciences (Autologous), Osiris Therapeutics (Allogeneic) Skin application Organogenesis, Bio. Tissue Technologies, Advanced Bio. Healing, Inc. , Genzyme Biosurgery, Fidia Advanced Biopolymers, Intercytex, Celltran, Forticell Bioscience, Cambrex Primary cells Progenitor cells Cartilage application Osiris Therapeutics (Allogeneic) Several applications: Cartilage application co. don, Educell, Geistlich Surgery, Genzyme Biosurgery, Interface Biotech, TIGenix, TETEC Advanced Cell Technologies, Geron, ES Cell International, Stem Cell Sciences, Aastrom Biosciences, Aldagen, Angioblast Systems, Athersys , Brain. Storm Cell Therapeutics, Cardio 3, Cellerant Therapeutics, Cognate Therapeutics , Gamida-Cell, Mesoblast , Neuronyx, Osiris Therapeutics, Adi. Stem, Bioheart, Cellerix, Cognate Therapeutics, Cytori Therapeutics , Re. Neuron Group Plc, Tengion, Pharma. Frontiers , Tissue Genesis, Inc , Gamida-Cell, Saneron CCEL Therapeutics, Via. Cell Other Cell Based Therapies Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline RECART Hydrogel/Adipose derived adult stem cells R&D and non-clinical development Biomaterial R&D In vitro testing MA Applic. Clinical development Marketing Authorization Phase III In Vivo. Testing GMP grade 2007 -2010 Phase IV 2010 -2018 Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. 2019 2020 Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Product Pipeline RECART Hydrogel/Adipose derived adult stem cells R&D and non-clinical development Biomaterial R&D MA Applic. Clinical development Marketing Authorization Phase II In vitro testing Phase III In Vivo. Testing GMP grade Phase IV Stemmatters Life Banking Stem cell isolation and storage services Stemmatters Biomedical Products and services for R&D 2007 -2010 -2018 Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. 2019 2020 Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Contacts Rui A. Sousa CEO Tel. +351 -253 -540100 Fax. +351 -253 -540199 E-mail: rasousa@stemmatters. com Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Stemmatters Life Banking Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Current Markets Main application markets for stem cells Current uses of stem cells are made in 3 distinct medical related markets: Cell banking; Therapeutic development; Cell therapies. (source: Frost & Sullivan). Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Current Offering Stemmatters Life Banking | Stem cell isolation and storage services Bone marrow (onstem service – B 2 C); Adipose tissue (adstem service – B 2 C): The treatment of tissues and biological residues generated in surgical procedures assures a cell banking opportunity not yet addressed. Market potential for the isolation and storage of adipose derived adult stem cells for autologous application is estimated to worth: • 75 million €/year for Spain, France, Germany, UK, Italy and Portugal; • 120 million €/year for EU 15. Assures a polyvalent platform for regenerative technologies; Assures positive cash flow and supports leveraging of R&D pipeline. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Competition Stemmatters Life Banking | Stem cell isolation and storage services Newborns Children Adults Crioestaminal, Bioteca, Bebé Vida, Criovida, Cytothera (Portugal) Bioeden (UK) Stemmatters USA Europe Celvitae, Vidacord, Secuvita, Vidaplus, Stem Cell, Crio. Cord, Safetycord (Spain) Cytothera (Portugal) Acti. Vision Life (Poland), Babycord (Cyprus), Babycord (Turkey), Biohellenica (Greece), Biophylaxis (Greece), BPK (Slovenia), Copy. Gene (Denmark), Cryo. Bank (Turkey), Cryo-Save (Belgium), Cryomedica (Russia), Eticur (Germany), Eurocord (Slovakia), Floramed (Russia), Gemabank (Russia), Gen. Kord (Turkey), Hemafund (Ukraine), In Scientia Fides (Italy), Krio (Hungary), Liaison (Greece), Life. Bank (Cyprus), Lifecord (Austria), Lifeline (Cyprus), Longa. Vita (Poland), Polish Stem Cell Bank (Poland), Progenis (Poland), RCB (Switzerland), Seracell (Germany), Smart. Bank (Italy), Stella. Cure (Germany), Stemcare (Denmark), Stem-Health Hellas (Greece), VITA 34 (Germany), Vitacord (Austria), Yasam Bankasi (Turkey), Cells 4 Life (UK), Cells Limited (UK), Cryo. GENESIS (UK), Future Health Technologies (UK), Smart. Cells (UK), UK Cord Blood Bank (UK), UK Health Solutions (UK), Virgin Health Bank (UK) Alpha. Cord, Cord. Banc. USA, Cord Blood America, Cord Blood Registry, Cord Blood Solutions, Cryobanks International, Cryo-Cell International, Domani. Cell, Elie Katz, Family CB Services, Family Link, Genesis Bank, Hema. Stem, Lifebank. USA, Life. Line, Life. Source, MAZE Labs, Neocells, Newborn Blood Banking, New England CB Bank, RMI, Safetycord, Securacell, Stem. Cyte, Stork Medical, Utah Cord Bank, Viacord, Vista Cord, Xytex Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Cryo-Save (Belgium) Cytori Therapeutics Biohellenika (Greece) Bioeden, Stem. Save, Baby Teeth Cell Bank Cryo-cell Neostem Cytori Therapeutics Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Current Offering Stemmatters Life Banking | Stem cell isolation and storage services Acquisition Drivers Increased value of the surgical procedure; Potential application in future autologous regenerative therapies; Allows for off the shelf availability of personalized regenerative products; Decreases time for clinical delivery of therapy. Current applications of adipose derived adult stem cells Radiation Necrosis Breast Reconstruction Heart Attack Chronic Heart Disease Crohn’s Disease Tracheal Fistula Healing Calvarial Repair Marrow Transplant Complications Diabetes Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Stemmatters Biomedical Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Current Offering Stemmatters Biomedical | Products and services for R&D Isolation and processing services of human cells: Human stromal vascular fraction isolated from adipose tissue containing human adipose derived stem cells (all samples are characterized for cell number and viability); Human adipose derived stem cells (all samples are characterized for cell number and viability, as well as multipotent mesenchymal stem cell markers: CD 29, CD 105, CD 34 and CD 45); • Pre-clinical research in regenerative medicine accounts for a market volume of about 700 million €/year. Cell culturing products; Hydrogel support systems for 3 D cell culturing; • Very high R&D visibility among the potential buyer community; • The global market potential for the commercialization of 3 D supports for non-clinical R&D is estimated to worth between 7 and 35 million €/year. Device for dynamic cell seeding and culturing. Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Corporate Strategy Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Corporate Strategy Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Financial projections Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS E-mail: rasousa@stemmatters. com Website: www. stemmatters. com

Financial Projections 2009 -2016 14. 0 12. 0 MEuros 10. 0 8. 0 6. 0 4. 0 2. 0 0. 0 -2. 0 7/1/1905 12: 00 AM 7/2/1905 7/3/1905 12: 00: 00 Operating income AM AM 7/4/1905 12: 00 AM Stemmatters, Biotecnologia e Medicina Regenerativa Lda AVEPARK - Parque de Ciência e Tecnologia S. A. 7/5/1905 12: 00 EBIT AM 7/6/1905 7/7/1905 12: 00: 00 Net result AM AM Zona Industrial da Gandra | S. Cláudio do Barco APARTADO 4152 | 4805 CALDAS TAIPAS 7/8/1905 12: 00 AM E-mail: rasousa@stemmatters. com Website: www. stemmatters. com