Statistical Parametric Mapping for f MRI VBM Guillaume

Statistical Parametric Mapping for f. MRI / VBM Guillaume Flandin Wellcome Trust Centre for Neuroimaging University College London SPM Short Course London, October 2016

Foreword Emergency exit Feedback forms Toilets Wi. Fi Slides “SPM Course” Questions http: //www. fil. ion. ucl. ac. uk/spm/course/london/

Programme Thursday 27 th October 9. 15 - 9. 45 Welcome: Introduction and Overview Guillaume Flandin 9. 45 - 10. 30 Spatial Preprocessing Ged Ridgway 10. 130 - 11. 00 Demo: Spatial Preprocessing Ged Ridgway Coffee 11. 30 - 12. 15 The General Linear Model Nadine Dijkstra Friday 28 th October 09. 30 - 10. 15 Event-related f. MRI Christian Ruff 10. 15 - 11. 00 Experimental design Mona Garvert Coffee 11. 30 - 12. 15 Demo: Event-related f. MRI Analysis Mona Garvert 12. 15 - 13. 00 Bayesian Inference Jean Daunizeau Lunch 12. 15 - 13. 00 Contrasts and Classical Inference Christophe Phillips Lunch 14. 00 - 14. 45 Group Analysis Guillaume Flandin 14. 45 - 15. 30 Random Field Theory Justin Chumbley Tea 16. 00 - 16. 45 Voxel-Based Morphometry John Ashburner 16. 45 – 17. 30 Demo: Voxel-Based Morphometry Claudia Blaiotta 17. 30 - 18. 00 “Questions and Answers” Clinic 14. 00 - 15. 00 Dynamic Causal Modelling for f. MRI Peter Zeidman 15. 00 - 16. 00 DCM for f. MRI: Advanced topics Peter Zeidman Tea 16. 30 – 17. 15 Demo: DCM for f. MRI Adeel Razi 17. 15 - 18. 00 “Questions and Answers” Clinic Karl Friston 18. 30 - Social event The Driver, N 1 9 RY

Social Event Friday evening: The Driver, 2 nd floor, N 1 9 RY

Social Event @ The Driver

Statistical Parametric Mapping Ø Concepts Ø Software Ø Resources

From PET analyses using ROIs…

…to the very first SPM{t} • An area specialised for the processing of colour, the“colour centre” (V 4) highlighted by cognitive substraction using PET. • Three subjects: Colour trials (2 scans) Grey trials (2 scans) • Compatible with earlier findings on monkeys using electrophysiology.

Image time-series Realignment Spatial filter Design matrix Smoothing General Linear Model Statistical Parametric Map Statistical Inference Normalisation Anatomical reference Parameter estimates RFT p <0. 05

M/EEG Data Analysis Random Contrast c Field Theory General Linear Model Preprocessings Statistical Inference

q Statistical Parametric Mapping refers to the construction and assessment of spatially extended statistical processes used to test hypotheses about functional imaging data. Pedobarographic statistical parametric mapping (p. SPM), T. Pataky, Journal of Foot and Ankle Research, 2008.

Voxel-Based Morphometry (VBM) q VBM is the most widely used method for computational neuroanatomy. q It is essentially Statistical Parametric Mapping of regional segmented tissue density or volume. q The same general linear modelling & RFT machinery in SPM can then be used to study differences in structure.

Dynamic Causal Models Nature, April 2012

SPM Software “The SPM software was originally developed by Karl Friston for the routine statistical analysis of functional neuroimaging data from PET while at the Hammersmith Hospital in the UK, and made available to the emerging functional imaging community in 1991 to promote collaboration and a common analysis scheme across laboratories. ” SPMclassic, SPM’ 94, SPM’ 96, SPM’ 99, SPM 2, SPM 5, SPM 8 and SPM 12 represent the ongoing theoretical advances and technical improvements of the original version.

Software: SPM 12 q Free and Open Source Software (GPL) q Requirements: Ø MATLAB: 7. 4 (R 2007 a) to 9. 1 (R 2016 b) no Math. Works toolboxes required Ø Supported platforms: Linux, Windows and Mac q Standalone version available.

Data File Formats q DICOM: Digital Imaging and Communications in Medicine q NIf. TI: Neuroimaging Informatics Technology Initiative Ø Nif. TI: volumetric data format (*. nii, *. hdr/*. img) Ø GIf. TI: geometry data format (*. gii) q Analyze. TM: Mayo Clinic Analyze 7. 5 file format (*. hdr/*. img) q Interoperability: Ø Compatible with AFNI, Brain. VISA, Brain. Voyager, Caret, Freesurfer, FSL, …

Brain Imaging Data Structure (BIDS) “A simple and intuitive way to organise and describe your neuroimaging and behavioural data. ” http: //bids. neuroimaging. io/

SPM Documentation Peer reviewed literature PDF Manual MATLAB code and comments SPM Book

SPM datasets PET, f. MRI (1 st and 2 nd level), PPI, DCM, EEG, MEG, LFP.

Open Science q Open Methodology q Open Source q Open Data q Open Access q Open Peer Review q Open Educational Resources https: //en. wikipedia. org/wiki/Open_science

SPM Toolboxes q User-contributed SPM extensions: http: //www. fil. ion. ucl. ac. uk/spm/ext/

SPM Mailing List http: //www. fil. ion. ucl. ac. uk/spm/support/ spm@jiscmail. ac. uk

References q Twenty years of functional MRI: The science and the stories. P. Bandettini, Neuro. Image, 2012. http: //dx. doi. org/10. 1016/j. neuroimage. 2012. 04. 026 q f. MRI 25: 25 years of an imaging revolution. http: //www. fmri 25. org/ q SPM’s 20 th Anniversary, K. J. Friston. http: //www. fil. ion. ucl. ac. uk/spm/course/video/#Overview

The SPM co-authors • Jesper Andersson • John Ashburner • Nelson Trujillo-Barreto • Gareth Barnes • Matthew Brett • Christian Buchel • CC Chen • Justin Chumbley • Jean Daunizeau • Olivier David • Guillaume Flandin • Karl Friston • Darren Gitelman • Daniel Glaser • Volkmar Glauche • Lee Harrison • Rik Henson • Andrew Holmes • Chloe Hutton • Maria Joao • Stefan Kiebel • James Kilner • Vladimir Litvak • Andre Marreiros • Jérémie Mattout • Rosalyn Moran • Tom Nichols • Robert Oostenveld • Will Penny • Christophe Phillips • Dimitris Pinotsis • Jean-Baptiste Poline • Ged Ridgway • Holly Rossiter • Mohamed Seghier • Klaas Enno Stephan • Sungho Tak • Bernadette Van Wijk • Peter Zeidman