SQUAMOUS PAPILLOMA a benign proliferation of stratified squamous
a benign proliferation of stratified squamous epithelium. a papillary or verruciform mass
a soft, painless, usually pedunculated, exophytic nodule with numerous fingerlike surface projections ("cauliflower" or wartlike appearance )
human papillomavirus (HPV) at least 24 types are associated with lesions of the head and neck totally integration with the DNA of the host cell Viral subtypes 6 and 11 have been identified in up to 50% of oral papillomas less than 5% in normal mucosal cells.
the most common of the soft tissue masses arising from the soft palate
Pointed projections blunted projections
A firm, white, rough, exophytic, pedunculated, nontender soft tissue enlargement on the right ventral tongue.
Histopathologic Features a proliferation of keratinized stratified squamous epithelium arrayed in fingerlike projections
fibrovascular connective tissue cores may show inflammatory changes
hyperkeratosis . acanthosis loose connective tissue
Keratin layer Granular layer
Occasional ………basilar hyperplasia and mitotic activity a normal maturation pattern
Koilocytes virus-altered epithelial clear cells with small dark (pyknotic) nuclei in the prickle cell layer keratohyaline granules cleared cytoplasm, shrunken, irregular nuclei