Splenic diffuse red pulp small Bcell lymphoma revision

Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features by George Kanellis, Manuela Mollejo, Santiago Montes-Moreno, Socorro-María Rodriguez-Pinilla, Juan C. Cigudosa, Patricia Algara, Carlos Montalban, Estella Matutes, Andrew Wotherspoon, and Miguel A. Piris haematol Volume 95(7): 1122 -1129 June 30, 2010 © 2010 by Ferrata Storti Foundation

Clinical features of the series. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

(A) Splenic histology, with diffuse infiltration erasing follicles, occupying both cords and sinusoids. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

Peripheral blood and flow cytometry data. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

Immunohistochemical and molecular features. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

Circulating blood neoplastic lymphoid cells, of small to medium size with condensed chromatin, round or slightly cleaved nuclear outline and villous cytoplasm. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

Bone marrow interstitial/intrasinusoidal infiltration, barely recognizable in some cases by (A) H & E and (B) CD 20 staining. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

Illustrations of the characteristic immunophenotype by IHC: (A) CD 20. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation

Overall survival probability for the series. George Kanellis et al. Haematologica 2010; 95: 1122 -1129 © 2010 by Ferrata Storti Foundation