Specific Interference of Urokinasetype Plasminogen Activator Receptor and

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Specific Interference of Urokinase-type Plasminogen Activator Receptor and Matrix Metalloproteinase-9 Gene Expression Induced by

Specific Interference of Urokinase-type Plasminogen Activator Receptor and Matrix Metalloproteinase-9 Gene Expression Induced by Double-stranded RNA Results in Decreased Invasion, Tumor Growth, and Angiogenesis in Gliomas* Sajani S. Lakka, Christopher S. Gondi, Dzung H. Dinh, William C. Olivero, Meena Gujrati, Velidi H. Rao, Chrissa Sioka, Jasti S. Rao Journal of Biological Chemistry Volume 280 Issue 23 Pages 21882 -21892 (June 2005) DOI: 10. 1074/jbc. M 408520200 Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Scheme 1 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Scheme 1 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 1 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 1 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 2 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 2 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 3 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 3 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 4 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 4 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 5 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 5 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 6 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 6 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Fig. 7 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Fig. 7 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

Scheme 2 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200)

Scheme 2 Journal of Biological Chemistry 2005 28021882 -21892 DOI: (10. 1074/jbc. M 408520200) Copyright © 2005 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

UVB Increases UrokinaseType Plasminogen Activator Receptor u PARUVB Increases UrokinaseType Plasminogen Activator Receptor u PAR
Plasminogen Activator Inhibitor1 Reduces TissueType Plasminogen Activator DependentPlasminogen Activator Inhibitor1 Reduces TissueType Plasminogen Activator Dependent
Plasminogen activators tPA uPA Plasminogen activator inhibitors PAIPlasminogen activators tPA uPA Plasminogen activator inhibitors PAI
Urokinase Plasminogen Activator u PA and its ReceptorUrokinase Plasminogen Activator u PA and its Receptor
INTERFERENCE Constructive Interference Destructive Interference YOUNG TWOSLIT INTERFERENCEINTERFERENCE Constructive Interference Destructive Interference YOUNG TWOSLIT INTERFERENCE
Prothrombinase Components Can Accelerate Tissue Plasminogen Activatorcatalyzed PlasminogenProthrombinase Components Can Accelerate Tissue Plasminogen Activatorcatalyzed Plasminogen
Circulating Fibronectin and Plasminogen Activator Inhibitor2 Levels asCirculating Fibronectin and Plasminogen Activator Inhibitor2 Levels as
Synergistic and Multidimensional Regulation of Plasminogen Activator InhibitorSynergistic and Multidimensional Regulation of Plasminogen Activator Inhibitor
Plasminogen Activator Inhibitor1 Levels and Activity Decrease AfterPlasminogen Activator Inhibitor1 Levels and Activity Decrease After