Southern California Science Olympiad Summer Workshop Protein Modeling

Southern California Science Olympiad Summer Workshop Protein Modeling C EMILY MIAOU

Differences from last year: • Proteins being modeled are from biosynthesis and signaling/binding of dopamine and serotonin • PENCIL/PEN must be used for the exam • MARKER must be used for marking toobers • Bring a METRIC RULER with cm marks to figure out model scale 12/3/2020 Southern California Science Olympiad Summer Workshop

Differences: • Model is of a fragment of SEPIAPTERIN REDUCTASE (residues 93261 of PDB entry 1 SEP. pdb) • Additions to the model should highlight the significance of structure to function of the protein • Explain additions to the model and what they represent in 500 words or less, single space, 10 point font. This REPLACES the notecard. 12/3/2020 Southern California Science Olympiad Summer Workshop

Sample Questions: • If a protein is membrane-bound, where would you expect to find hydrophilic amino acids? • If you are discussing the sequence of amino acids in a polypeptide chain, are you talking about a protein’s primary, secondary, tertiary, or quaternary sequence? • Which of the following amino acids contains sulfur? • Tryptophan • Methionine • Glutamic acid • Histidine Southern California Science Olympiad Summer Workshop 12/3/2020

12/3/2020 Southern California Science Olympiad Summer Workshop

Resources http: //cbm. msoe. edu/science. Olympiad/index. php (http: //cbm. msoe. edu/teach. Res/library/available. html) http: //scioly. org/wiki/index. php/Protein_Modeling 12/3/2020 Southern California Science Olympiad Summer Workshop