Something we learn from textbook White fat cell

Something we learn from textbook • White fat cell – Store energy – Monolocular(单房的) • Brown fat cell – Dissipate energy [high mitochondrial UCP 1(uncoupling protein 1)] – Multilocular – In small mammals, not in large mammals after infancy

Some new progress • “brown conversion”of white fat cold or c. AMP White fat tissue • UCP 1﹣ • UCP 1+ brown fat cell • UCP 1+ • Derived from myf-5 lineage • Brown fat in adult humans – UCP 1+ – Particularly in supraclavicular and neck region

Questions • Beige fat cell is a distinct cell type or derived from white fat cells ？ • The brown fat tissue in adult human is classical brown fat or beige fat ?

第一PPT模板网 WAT: white adipose tissue BAT: brown adipose tissue Lecturer: Cao Lijie

Beige adipocyte in white fat Beige fat cell readily detectable in Inguinal subcutaneous fat depot • Multilocular • UCP 1 between WAT and BAT Inguinal subcutaneous fat depot Epididymal WAT Brown fat cell-enriched protein

Beige adipocyte in white fat Ing Immortalization(无限增殖) … … differentiate … White fat cell … beige fat cell Beige fat cell is derived from a subset of precursor cells within white fat. cell lines

characteristics of Beige cells (By c. AMP) Brown fat-- enriched protein

Brown fat in adult humans are beige fat cells

highlights sub. Q WAT Beige adipogenic cells White adipogenic cells Sympathetic stimulation Beige adipocyte “Brown” fat in human adults is composed of beige adipocytes