Somatic hypermutation analysis in follicular lymphoma provides evidence Slides: 7 Download presentation Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during disease progression and relapse by Martin Wartenberg, Peter Vasil, Christian Meyer zum Bueschenfelde, German Ott, Andreas Rosenwald, Falko Fend, and Marcus Kremer haematol Volume 98(9): 1433 -1441 September 4, 2013 © 2013 by Ferrata Storti Foundation Formula for calculating the probability measure (pm). Martin Wartenberg et al. Haematologica 2013; 98: 1433 -1441 © 2013 by Ferrata Storti Foundation Histological grade and clinical course/stage of follicular lymphoma specimens analyzed. Martin Wartenberg et al. Haematologica 2013; 98: 1433 -1441 © 2013 by Ferrata Storti Foundation Average mutation rates and mutation rate ranges of sequenced clones. Martin Wartenberg et al. Haematologica 2013; 98: 1433 -1441 © 2013 by Ferrata Storti Foundation Pedigree of the final FL cell evolution of patient 1 – synopsis of compartment-specific and intercompartment pedigrees. Martin Wartenberg et al. Haematologica 2013; 98: 1433 -1441 © 2013 by Ferrata Storti Foundation Pedigree of the final FL cell evolution of patient 2 – synopsis of compartment-specific and intercompartment pedigrees. Martin Wartenberg et al. Haematologica 2013; 98: 1433 -1441 © 2013 by Ferrata Storti Foundation Pedigree of the final FL cell evolution of patient 3 – synopsis of compartment-specific and intercompartment pedigrees. Martin Wartenberg et al. Haematologica 2013; 98: 1433 -1441 © 2013 by Ferrata Storti Foundation Affinity maturation somatic hypermutationSomatic hypermutationFollicular nonhodgkins lymphomaEvidence for evolutionThe coriolis effect provides evidence thatInductive leapCarcinoma vs adenomaThyroid parafollicular cells