Skin I Nonneoplastic Diseases Kristine Krafts M D
- Slides: 51
Skin I Non-neoplastic Diseases Kristine Krafts, M. D.
Non-Neoplastic Skin Outline • Introduction • Infectious disorders • Inflammatory disorders • Bullous disorders
Non-Neoplastic Skin Outline • Introduction
Normal skin
Erythema: redness Macule: flat lesion Patch: a large macule (<1 cm) Papule: a raised lesion Plaque: a large papule (>1 cm) Vesicle: a blister Bulla: a big blister Pustule: a blister that contains pus
Non-Neoplastic Skin Outline • Introduction • Infectious disorders
Impetigo • S. aureus or S. pyogenes • Children • Crusty pustules on face
Impetigo
Impetigo
Erysipelas • S. aureus or S. pyogenes • Face/scalp • Sharply-circumscribed, erythematous plaque
Erysipelas
Necrotizing Fasciitis • Many potential organisms • Redness, pain evolving into gangrene • Need early surgical intervention and IV antibiotics
Necrotizing fasciitis
Acne • Proprionibacterium acnes • Sebaceous glands get plugged, then bacteria cause inflammation of the hair follicle/sebaceous gland • Comedones (blackheads) and/or pustules
Acne vulgaris
Acne vulgaris
Acne rosaceae
Acne rosaceae
Ringworm (Tinea) • Named by anatomic site (e. g. , tinea pedis = ringworm of foot (athlete’s foot), tinea corporis = ringworm on body) • Red, inflamed, sometimes-scaly round lesions • More common in children
Tinea corporis
Sporotrichosis • Sporotrichum schenkii • “Rose gardener’s disease” • Painless papule, then open sore
Sporotrichosis
Verruca Vulgaris • Common wart • HPV
Verruca vulgaris
Herpes Simplex • HSV I (usually causes cold sores) • HSV II (usually causes genital herpes)
Herpes simplex
Herpes simplex
Molluscum Contagiosum • Pox virus • Centrally-umbilicated red papules • Very contagious
Molluscum
Erythema Multiforme • Usually HSV; sometimes drug-related • “Target” lesions and/or vesicles on skin, mucous membranes • Stevens-Johnson syndrome is a rare, very severe disease with skin necrosis.
Erythema multiforme
Scabies • Sarcoptes scabei • Worldwide epidemic • Hands/wrists, abdomen/groin • Itchy rash
Scabies
Non-Neoplastic Skin Outline • Introduction • Infectious disorders • Inflammatory disorders
Psoriasis • Common, chronic, inherited disease • Itchy red lesions with silvery scales • Patients may also have arthritis of hands
Psoriasis
Lichen Planus • Common, chronic, immune-mediated disease • Skin: purple polygonal papules • Mucous membranes: lacy-appearing lesions (Wickham’s striae), erosions, or leukoplakia
Lichen planus
Wickham’s striae
Atopic Eczema • Usually inherited • Itchy rash • Often history of atopic disease (asthma, hayfever)
Atopic eczema
Non-Neoplastic Skin Outline • Introduction • Infectious disorders • Inflammatory disorders • Bullous disorders
Pemphigus Vulgaris • Antibodies against spot desmosomes (connect epithelial cells to each other) • Adults (40 s-50 s) • Mouth first, then skin • Superficial bullae that rupture easily
Pemphigus vulgaris
Pemphigus vulgaris
Pemphigus vulgaris
Bullous Pemphigoid • Antibodies against hemidesmosomes (connect epidermis to basement membrane) • Elderly • Groin, axilla, arms • Big, subepidermal bullae
Bullous pemphigoid
Bullous pemphigoid
Bullous pemphigoid
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