Siegfried Benkner Institute of Scientific Computing University of

Siegfried Benkner Institute of Scientific Computing University of Vienna, Austria for the Aneurist Consortium www. aneurist. org October 5, 2007

http: //www. aneurist. org EU Project @neur. IST (2006 -2009) IST-2004 -027703 Development of a generic IT infrastructure for the management and processing of heterogeneous data associated with the diagnosis and treatment of cerebral aneurysms and subarachnoid haemorrhage. Integrated Application Suites @neu. Risk - personalised risk assessment @neu. Endo – virtual endovascular treatment planning & stent design @neu. Link - linking genetics to disease @neu. Fuse - modeling, simulation & visualization of multimodal data @neur. IST service-oriented Grid infrastructure on-demand simulation and analysis services (semantic) data-integration services handling multi-scale, multi-modal information at distributed sites. 2 @neur. IST Copyright © 2007

Integrative Application Suites Patient Imaging data Gen data Personal data Modelling, simulation and analysis services @neu. Fuse Epidemiology knowledge @neur. IST @neu. Link Genetic risk databases @neu. Risk Pharma treatment Copyright © 2007 @neu. Endo Modelling, simulation 3 and analysis services

@neur. IST Grid Infrastructure @neur. IST Controller @neu. Risk Integrative rupture risk assesment @neu. Linking genetics to disease @neu. Endo @neu. Fuse Virtual endovascular treatment planning Multimodal data processing&fusion Application Layer @neur. IST Client API @neu. Compute Services Job Execution Data Transfer @neu. Info Services Middleware Layer OGSA-DAI GDMS Basic @neur. IST Grid Layer (GEMSS 2 / Inner. Grid) Modeling Simulation Analysis Databases Compute Resources Files Storage Resources Bio. IS Resource Layer Grid Middleware: GEMSS 2, Inner. Grid; Standard Web Services (WS-I) Data Integration: OGSA-DAI – WS-DAI; DQP; SQL 4 Semantics: OWL, SPARQL @neur. IST Copyright © 2007

Data Integration Approach Semantic Data Mediation Federation of Services CRIM, Ontology Security, Pseudonymization, … EHR EHR Hospital information systems Sheffield, Geneva, Rotterdam, … EHR, PACS, … Public databases PDD Genetic: EBI, NCBI Literature: Medline, etc. Product design databases Data Service GDMS OGSA/DAI PUBMED COTS stents, coils, etc. PACS @neur. IST PACS Copyright © 2007 Applications 5 Users

Clinical Reference Information Model (CRIM) Defines all information to be captured for a patient clinical information (imaging, diagnostic and treatment data, …) administrative information research results produced (indicators) Treatment context Research Context Normalization De-identification Knowledge discovery Federated Data Capturing Imaging data Patient record Information aquisition & structuring Denormalization Re-identification Biomedical Info Structure Information access, analysis & enrichment Application Suites Processing & Analysis Distributed queries Biomedical data infostructure Two different architectures (see next slide) @neur. IST Copyright © 2007 6

FIREWALL FIREWALL FIREWALL FIREWALL Sheffield (ANO) University network/DMZ Logging Filtering SQL ano. DB ery u Lq ith L XM Internet w WS SQ SQ L XM L Geneva (OTF) qu er y @neur. IST Files Data Access Hospital DMZ Logging Filtering Public @neu. Info Service DVD FTP Data Storage FIREWALL FIREWALL wi th FIREWALL FIREWALL W S Public @neu. Info Service Push mechanism Copyright © 2007 Hospital Intranet EHR PACS HL 7 DICOM Acquisition tool XML/DICOM files HTTP/XML IDDB Data Acquisition Hospital Intranet Data forms EHR HTTP/XML DICOM PACS HTTP/XML Private @neu. Info Service 7 IDDB

@neur. IST Ontology Global conceptual schema of the disease Conceptual space Clinical Medicine Molecular Biology Epidemiology Simulation Disease Risk factor Classes Relationship Definitions UMLS Types Map 2139 85 1096 1183 Incorporating “approved” existing ontologies FMA - Foundational Model of Anatomy GO - Gene Ontology DOLCE as Upper Ontology Concepts are mapped to Unified Medical Language System (UMLS) OWL-DL Lead partner: University of Freiburg 8 @neur. IST Copyright © 2007

Semantic Data Integration Data Mediation Services Virtual Schema Ontology GDMS Mapping annotation Schema DAS

@neur. IST Security Architecture Pseudonymisation Service End-to-end security Attribute-based access control (ABAC) Certificate and Registration Authorities; Federated VO model Security Token Service Logging, Filtering Services Auditing Provenance built on top of Web services security standards 10 @neur. IST Copyright © 2007

Contact Project co-ordinator: Universitat Pompeu Fabra Contact person: Dr. Alejandro Frangi Tel: +34 93 542 14 51 Fax: +34 93 542 25 17 Email: alejandro. frangi@upf. edu WWW: http: //www. aneurist. org 11 @neur. IST Copyright © 2007