Sheila A Caldwell Ph D Program Director Division

Sheila A. Caldwell, Ph. D. Program Director Division for Research Capacity Building National Institute of General Medical Sciences (NIGMS) Native American Research Centers for Health (NARCH) Program

National Institute of General Medical Sciences (NIGMS) Mission v Supports basic research and research in specific clinical areas that affect multiple organ systems v Provides leadership for the training of next generation of scientists v Develops and increases workforce diversity v Promotes capacity building in research infrastructure and networking

NIGMS Divisions/Center (http: //www. nigms. nih. gov) Division for Research Capacity Building Biomedical Technology, Bioinformatics, and Computational Biology NIGMS Training, Workforce Development, and Diversity Pharmacology, Physiology, and Biological Chemistry Cell Biology and Biophysics Genetics and Developmental Biology

Division for Research Capacity Building (DRCB) Administered Programs Institutional Development Award (IDe. A) Native American Research Center for Health (NARCH) Support of Competitive Research (SCORE) Science Education Partnership Award (SEPA)

NARCH Program Background: v Trans-NIH Program with an average of 15 NIH Institutes and Centers (ICs) and NIH Offices signed on. Past and current participating ICOs • NIGMS, NCI, NHLBI, NHGRI, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCR, NIDDK, NIEHS, NIMHD, NCCIH, ORWH, and OBSSR, ODSS v Partnership between NIH and Indian Health Service v Support for research capacity-building in American Indian/Alaska Native (AI/AN) communities to address health issues pertinent to AI/AN populations and provide research experience training for faculty and students

Background v NARCH program began in 2001 in collaboration with IHS v Each participating NIH IC can support projects from different grant applications without supporting the whole grant v 73 NARCH grants have been awarded since the start of the program v Research Capacity-Building component was added to the NARCH FOA in 2012 v Program management was moved to NIGMS in FY 2017 v The FOA is issued for 2 consecutive years and is then quiescent for 2 years

FY 2020 NARCH Support by IC NIDCR $97, 281 NIAAA NIDDK $543, 534 NIA MS $500, 000 $25 0, 0 00 NIDA $1, 150, 648 OBSSR $465, 910 0 $200, 00 NIEHS 8 24, 25 2 $ D NIAI NCI NIMHD $97, 200 $571, 447 ORWH $75, 000 NIGMS $6, 144, 212

NARCH Funding Opportunity Announcement (PAR 20 -125) NARCH Program Goal Specifics: v To support health research projects prioritized by the tribal communities v To support development and research experiences of students, scientists and health professionals engaged in AI/AN health research v To increase research capacity for health research targeted towards AI/AN populations v To support collaborations between federally recognized AI/AN tribal entities and researchintensive institutions

NARCH S 06 Application https: //grants. nih. gov/grants/guide/pa-files/PAR-20 -125. html v The application must be from and the award must be made to a federally recognized tribe or tribal organization. • A non-AI/AN research-intensive university cannot apply for a NARCH. v The annual budget must not exceed $1 million in direct costs. v At least 30% of the budget must remain with the eligible AI/AN applicant organization(s). v Awards are made for 4 years. v Next receipt date is June 24, 2021

NARCH Program Model v Application must include: • Administrative Core v Applications include any combination of: • • Student Career Enhancement Project Faculty Career Enhancement Project Capacity Building Project Research Project (including Pilot Projects) v No overarching scientific theme is required for the application. • Rather, the overarching goal of the application should be focused on the health research needs and requests of the AI/AN community.

Current NARCH awards • • • • Diné College, Mark Bauer (PI) Black Hills Center for American Indian Health, Jeffrey Henderson (PI) White Mountain Apache Tribe, Mariddie Craig (PI) (2) Northwest Portland Area Indian Health Board, Thomas Becker (PI) (2) South. Central Foundation, Renee Robinson (PI) Northwest Indian College, Stacy Rasmus (PI) Cherokee Nation, Sohail Khan (PI) (2) Great Lakes Inter-Tribal Council, Inc, Adrienne Laverdure (PI) Alaska Native Tribal Health Consortium, Elizabeth Ferucci (PI) Albuquerque Area Indian Health Board, Kevin English (PI) Inter Tribal Council of Arizona, Maria Dadgar (PI) Healing lodge of the Seven Nations, Martina Whelshula (PI) Indian Health Council, Inc, Daniel Calac (PI)

NARCH FY 20 Recipient Institutions Northwest Indian College WA MT Healing Lodge of the Seven Nations Northwest Indian College ND Black Hills Center for American Indian Health OR ID Northwest Portland Area Indian Health Board WY collaboration SD IA NE NV UT CO KS Indian Health Council AZ Diné College Cherokee Nation NM White Mountain Apache Tribe NARCH IN PA OH WV KY VA TN AR MS TX NY MI MO OK OK Albuquerque Area Indian Health Board VT WI IL CA Inter-Tribal Council of Arizona MN Great Lakes Inter-Tribal Council, Inc. AL NC GA SC LA South. Central Foundation AK FL Alaska Native Tribal Health Consortium HI PR ME NH CT DE MD RI MA

Examples of Current NARCH Projects • • “Student Enhancement Project”, Diné College “Cigarette Smoking among American Indian Women Experiencing Intimate Partner violence”, Black Hills Center for American Indian Health “Developing and evaluating a culturally grounded Mother-Daughter intervention to promote protective factors and reduce early substance use among Apache girls”, White Mountain Apache Tribe "Enhancing Control of Childhood Asthma in AI/AN Communities“, Northwest Portland Area Indian Health Board “Faculty Development”, South. Central Foundation “Native Transformations Opiate Project”, Northwest Indian College “Breast Cancer patterns of Care and Outcomes by Diabetes Status Among American Indians in Cherokee Nation”, Cherokee Nation

Examples of Current NARCH Projects • • “Student & Faculty Development”, White Mountain Apache Tribe • “Molecular Phenotyping of Autoimmunity in Tribal Members: Aiding Precision Medicine and Tribal Student Training”, Cherokee Nation • “Resource Network for Building Capacity at NARCH Research Partnerships”, Great Lakes Inter-Tribal Council, Inc • “Impact of Prenatal Vitamin D Supplementation on Prenatal Vitamin D Concentrations and Early Childhood Caries”, Alaska Native Tribal Health Consortium • “Tribal Equine Assisted Psychotherapy: Building Youth Resiliency Through Horses”, Albuquerque Area Indian Health Board • “Undergraduate Student Career Enhancement Project”, Inter Tribal Council of Arizona • • “Capacity Building Core”, Healing lodge of the Seven Nations "Improving Health Research Skills for AI/AN Students and Fellows”, Northwest Portland Area Indian Health Board “Child Development Resource Center, A Model of Collaborative, Culturally Congruent, Family-focused Care”, Indian Health Council, Inc

NARCH Scientific Highlight Oklahoma Native American Research Centers for Health Background: v Rheumatic diseases cause significant morbidity within American Indian populations. v Clinical disease presentations, as well as historically associated autoantibodies, are not always useful in making a rapid diagnosis or assessing prognosis. v The purpose of this study is to identify autoantibody associations among Oklahoma tribal populations with rheumatic disease. Scientific Advance: v Results published by this study indicate that cyclic citrullinated protein Ig. G (anti. CCP) may serve as a more specific rheumatoid arthritis (RA) biomarker in American Indian patients (J Rheumatol. 2012. Oct; 39(10): 1934 -41. PMCID: PMC 3468952).

NARCH Highlight Southwest Tribal American Research Center for Health (Albuquerque Area Indian Health Board) Aims: v Support research internships for American Indian higher education to develop skills to conduct behavioral and health science research v Provide mentoring and social support to students Successes: v Provided tuition scholarships to 33 AI/AN graduate-level students v Supported 18 AI/AN students through graduation with health science degrees

Questions? Sheila Caldwell: caldwells@mail. nih. gov