Sex is determined by sex chromosome SRY Sex
性别决定 Sex is determined by sex chromosome
SRY: Sex determination Region on the Y chromosome
Sufficiency: transgenic
遗传(genetics) and 表观遗传(epigenetics) 遗传 表观遗传
Epigenetic phenomena Drosophila study Polycomb and Trithorax Sex comb Not determined by DNA sequence
B Histones + SAM-CH 3 + Enzyme
Imprinted genes
Imprinting: allelic specific silencing
The Problem: Dosage difference X/Y contain different number of genes
When is X-chromosome inactivated?
Epigenetic regulation of X inactivation
Heterochromatin formation
Epigenetics in cancer
Epigenetics with i. PS
Nature. 2009 Mar 18
Histone marked enhancers are cell type specific
Expression of cell-type specific genes associates with specific enhancers
Life cycle of C. elegans
Progressive reduction of brood size in spr-5 ko
Percentage of sterile animals
H 3 K 4 me 2 retention in mutant animals
Spr-5 regulated oogenesis and spermatogenesis
Outcross abolished epigenetic memory
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