Screening for Early Detection and Prevention of Heart
- Slides: 45
Screening for Early Detection and Prevention of Heart Attack Morteza Naghavi, M. D. Society for Heart Attack Prevention and Eradication (SHAPE) Houston, TX March 2010 American College of Cardiology
> 15 Million Heart Attacks Each Year Source: World Heart Federation The AEHA 2005 VP Summit
Why does screening for the prevention of heart attacks need to look beyond cholesterol and traditional risk factors?
Because traditional risk factor based screening fails miserably in identifying the Vulnerable Patient.
Of 136, 905 patients hospitalized with CAD, 77% had normal LDL levels below 130 mg/dl Modified from Sachdeva et al. AHJ, Vol 157, 111 -117 Jan 2009 Chapter 1: Preventive Cardiology; the SHAPE of the Future in Naghavi et al. Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press, 2009
Of 136, 905 patients hospitalized with CAD, 45. 4% had normal HDL levels above 40 mg/dl Modified from Sachdeva et al. AHJ, Vol 157, 111 -117 Jan 2009 Chapter 1: Preventive Cardiology; the SHAPE of the Future in Naghavi et al. Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press, 2009
Of 136, 905 patients hospitalized with CAD, 61. 8% had normal triglyceride levels below 150 mg/dl Modified from Sachdeva et al. AHJ, Vol 157, 111 -117 Jan 2009 Chapter 1: Preventive Cardiology; the SHAPE of the Future in Naghavi et al. Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press, 2009
In >50% of victims, the first symptom of asymptomatic atherosclerosis is sudden cardiac death or acute MI.
Sudden Cardiac Death or Acute MI as Initial Presentation of CHD 62% Men 42% Women 0 10 20 30 40 50 Patients Diagnosed with CHD (%) 60 70 Murabito et al Circulation 1993
CONCLUSION: Status Quo Unacceptable
In summary: Two Major Problems Exist in Cardiology Today: 1 - Inaccurate Individualized Risk Assessment 2 - Inadequate Monitoring of Response to Therapy
Who Has More Cardiovascular Risk Factors? Sir Winston Churchill, 91 Jim Fixx, 53
~50% Apparently Healthy People (New) ~50% CHD Patients (Recurrent) CVD Genotyping? Naghavi et al. Circulation. 2003; 108: 1664
~50% Apparently Healthy People (New) ~50% CHD Patients (Recurrent) CVD Genotyping? Naghavi et al. Circulation. 2003; 108: 1664
The Vulnerable Patient Consensus Statement Preceding the SHAPE Initiative Naghavi et. al. Circulation Journal Vol 108, No 14; October 7, 2003
The Vulnerable Patient Consensus Statement Preceding the SHAPE Initiative Naghavi et. al. Circulation Journal Vol 108, No 14; October 7, 2003
First SHAPE Symposium - 2004
SHAPE Task Force Meeting - 2004
SHAPE Guidelines Published
SHAPE Guidelines Published
SHAPE v. s. Status Quo Existing Guidelines (Status Quo): • Screen for Risk Factors of Atherosclerosis • Treat Risk Factors of Atherosclerosis The SHAPE Guidelines: • Screen for Atherosclerosis (the Disease) Regardless of Risk Factors • Treat based on the Severity of the Disease and its Risk Factors
1: No history of angina, heart attack, stroke, or peripheral arterial disease. 2: Population over age 75 y is considered high risk and must receive therapy without testing for atherosclerosis. 3: Must not have any of the following: Chol>200 mg/dl, blood pressure >120/80 mm. Hg, diabetes, smoking, family history, metabolic syndrome. 4: Pending the development of standard practice guidelines. 5: High cholesterol, high blood pressure, diabetes, smoking, family history, metabolic syndrome. 6: For stroke prevention, follow existing guidelines.
Some of the Members of the SHAPE Task Force (left to right): Drs Budoff, Falk, Rumberger, Naghavi, Fayad, Hecht, and Berman
Current National Preventive Care Reimbursement Policies Do Not Match the Burden of the Problem Inadequate & Disproportionate
Magnitude of the Burden: Causes of Death in the United States Deaths (thousands) 959. 2 544. 7 93. 8 CHD Cancer 32. 7 Accidents HIV/AIDS American Heart Association. Heart and Stroke Statistical Update.
Why do we screen for asymptomatic cancers but ignore asymptomatic CVD?
<$100 for # 1 killer >$1000 for # 2 Killer
TEXAS HEART ATTACK PREVENTIVE SCREENING LAW Sec. A 1376. 003. AAMINIMUM COVERAGE REQUIRED. (a) A health benefit plan that provides coverage for screening medical procedures must provide the minimum coverage required by this section to each covered individual: (1)who is: (A)a male older than 45 years of age and younger than 76 years of age; or (B)a female older than 55 years of age and younger than 76 years of age; and (2)who: (A)is diabetic; or (B)has a risk of developing coronary heart disease, based on a score derived using the Framingham Heart Study coronary prediction algorithm, that is intermediate or higher. (b)the minimum coverage required to be provided under this section is coverage of up to $200 for one of the following:
TEXAS HEART ATTACK PREVENTIVE SCREENING LAW noninvasive screening tests for atherosclerosis and abnormal artery structure and function every five years, performed by a laboratory that is certified by a national organization recognized by the commissioner by rule for the purposes of this section: (1) computed tomography (CT) scanning measuring coronary artery calcification; Or (2) ultrasonography measuring carotid intima-media thickness and plaque.
Cost Effectiveness of the SHAPE Guidelines Number (per year) Estimated Impact of SHAPE (Sensitivity Analysis Range) Estimated Change in Cost 910, 600 ↓ 10% (5%-25%) ($1. 2 b) MI (prevalence) 7, 200, 000 ↓ 25% (5%-35%) ($18. 0 b) Chest Pain Symptoms (ER visits) 6, 500, 000 ↓ 5% (2. 5%-25%) ($4. 1 b) Hospital Discharge for Primary Diagnosis of CVD 6, 373, 000 ↑ 10% (5%-25%) $3. 8 b Hospital Discharge for Primary Diagnosis of CHD 970, 000 ↓ 10% (5%-25%) ($9. 9 b) ↑ 50 % (50%-65%) 8. 00 b CVD Deaths Cholesterol Lowering Therapy CV Imaging 8, 700, 000 ↑ 10% (5%-25%) Angiography 6, 800, 000 ↑ 15% - CTA (2. 5%-25%) $600 m PCI (percutaneous coronary interventions per year) 657, 000 ↓ 10% (5%-50%) ($580 m) CABS (coronary artery bypass surgeries per year) 515, 000 ↓ 5% (2. 5%-50%) ($672 m) Total Δ in Cost $358 m ($21. 5 b)
Comparing to the treatment of a heart attack, its prevention is woefully under-invested.
po ly pi lls
The ultimate preventive strategies must be directed towards the different levels of primary prevention (i. e. prevention of atherosclerosis risk factors in the entire population, mass treatment of atherosclerosis in a smaller at -risk population, and preemptive prevention of events in further smaller pre-symptomatic population. The 1 st SHAPE guideline is directed at the early detection and treatment of subclinical atherosclerosis and fills the gap in the existing guidelines.
WWW. SHAPESOCIETY. ORG
The 1 st SHAPE Textbook Released at the ACC 2010
The 1 st SHAPE –a-thon with onsite cardiovascular screen held in conjunction with annual scientific conference of American College of Cardiology 2005
The 1 st Golf Fore Heart championed by a SHAPE volunteer in Baltimore - 2007
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