Scleroderma Morphea Dr Rzan Objectives 1 define Identify
Scleroderma (Morphea). Dr. Rzan
Objectives: � 1 - define & Identify the CT. disease morphea.
Scleroderma �Localized Scleroderma (Morphea). �Scleroderma derived from the Greek terms skleros, hard, and derma, skin and means hard skin. �Localized scleroderma (LS) or morphea encompasses a group of disorders characterized inflammatory sclerosis (thickening) and fibrosis of the skin± subcutaneous tissue, fascia and/or adjacent muscle
The cause of morphea � is unknown. ØGenetic ØEnvironmental factors: trauma , Radiation, infectious , vaccination. ischemic injury Ø Such triggers may have a role in in the activate the of immune system and initiate fibrosis. �Morphea is commoner in women, 6 and 2. 6: 1.
Biopsy specimen � normal epidermis. � sclerosis of the dermis. � periadnexal inflammation. � sweat glands are entrapped by higher in the dermis.
Clinical presentation Localised morphea may be divided into 5 subtypes: �Plaque. �Guttate. �Linear. �En Coup de Sabre �. Deep.
Diagnosis and Measurement of Disease Activity �The diagnosis is based on: Ø clinical findings Ø histology Characteristic. �clinical features suggestive of active disease Ø include extension of lesions, Ø appearance of new lesions Ø presence of a violaceous halo.
Therapy �Topical Corticosteroids: (high potency ) “first-line” treatment for patient with plaque morphea. �Ultraviolet A. �(PUVA). �UVA 1 with topical calcipotriol ointment. �Antimalarials. �Methotrexate. �Interferon-_ .
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