Schistosomiasis Schistosoma haematobium Schistosoma mansoni Schistosoma japonicum A

Schistosomiasis Schistosoma haematobium Schistosoma mansoni Schistosoma japonicum

A Brief History. . . First described by German pathologist • Theodore Maximilian Bilharz • Bilharz performed autopsies on Egyptian • patients who had died from the disease: found male & female parasite eggs in the liver portal system, bladder. Later seen in Japan, called Katayama fever • Symptoms: rash on legs, fever, diarrhoea, – bloody stools emaciation, edema death.

Schistosoma v. General character: v Morphology v Reproduction system v Importance

Morphology • Size: - Female 12 to 26 mm - Male 6 to 22 mm The three main species infecting humans are Schistosoma haematobium, S. japonicum , and S. mansoni. Two other species, more localized geographically, are S. mekongi and S. intercalatum

Adult an larve of Schistosomulum

Geographic Distribution • Schistosoma mansoni is found in parts of South America and the Caribbean, Africa, and the Middle East ; • S. haematobium in Africa and the Middle East; and • S. japonicum in the Far East. • Schistosoma mekongi and S. intercalatum are found focally in Southeast Asia and central West Africa, respectively.

Life Cycle

Schistosoma spp. : miracidium

Schistosoma spp. cercariae are the infective forms. After encountering the skin, the cercariae penetrate and lose the tail transforming into schistosomulae

S. haematobium Biomphalaria

S. mansoni Oncomelania

Miracidium & Cercaria

Liver worm

Schistosoma egg • JK Sch. mansoni egg Sch. Haematobium egg Sch. japonicum egg

Epidemiology of Schistomiasis

Cercarial Dermatitis

Hepatomegaly & splenomegaly

Granuloma ( Sch. japonicum egg)

Granuloma ( Sch. hematobium egg)

Granuloma

Laboratory Diagnosis • Microscopic identification of eggs in stool or urine is the most practical method for diagnosis. • • Stool examination should be performed when infection with S. mansoni or S. japonicum is suspected, • and urine examination should be performed if S. haematobium is suspected. Tissue biopsy (rectal biopsy for all species and biopsy of the bladder for S. haematobium) may demonstrate eggs when stool or urine examinations are negative.